日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Inhibition of Rho-Associated Kinases ROCK1 and ROCK2 as a Therapeutic Strategy to Reactivate the Repressed FXN Gene in Friedreich Ataxia

抑制 Rho 相关激酶 ROCK1 和 ROCK2 作为治疗弗里德赖希共济失调症中激活被抑制的 FXN 基因的策略

Fang, Minggang; Banday, Shahid; Deibler, Sara K; Simone, Tessa M; Coleman, Madison; O'Connor, Emerald; Li, Rui; Zhu, Lihua Julie; Green, Michael R

The histone H3K9 demethylase KDM3A promotes anoikis by transcriptionally activating pro-apoptotic genes BNIP3 and BNIP3L

组蛋白H3K9去甲基化酶KDM3A通过转录激活促凋亡基因BNIP3和BNIP3L来促进失巢凋亡。

Pedanou, Victoria E; Gobeil, Stéphane; Tabariès, Sébastien; Simone, Tessa M; Zhu, Lihua Julie; Siegel, Peter M; Green, Michael R

Targeted Inhibition of PAI-1 Activity Impairs Epithelial Migration and Wound Closure Following Cutaneous Injury

靶向抑制PAI-1活性会损害皮肤损伤后的上皮细胞迁移和伤口愈合

Simone, Tessa M; Longmate, Whitney M; Law, Brian K; Higgins, Paul J

A small molecule PAI-1 functional inhibitor attenuates neointimal hyperplasia and vascular smooth muscle cell survival by promoting PAI-1 cleavage.

小分子 PAI-1 功能抑制剂通过促进 PAI-1 裂解来减弱新生内膜增生和血管平滑肌细胞存活

Simone Tessa M, Higgins Stephen P, Archambeault Jaclyn, Higgins Craig E, Ginnan Roman G, Singer Harold, Higgins Paul J

SERPINE1: A Molecular Switch in the Proliferation-Migration Dichotomy in Wound-"Activated" Keratinocytes

SERPINE1:伤口“激活”角质形成细胞增殖-迁移二分法中的分子开关

Simone, Tessa M; Higgins, Craig E; Czekay, Ralf-Peter; Law, Brian K; Higgins, Stephen P; Archambeault, Jaclyn; Kutz, Stacie M; Higgins, Paul J

The basic helix-loop-helix/leucine zipper transcription factor USF2 integrates serum-induced PAI-1 expression and keratinocyte growth

碱性螺旋-环-螺旋/亮氨酸拉链转录因子USF2整合了血清诱导的PAI-1表达和角质形成细胞生长。

Qi, Li; Higgins, Craig E; Higgins, Stephen P; Law, Brian K; Simone, Tessa M; Higgins, Paul J

Chemical Antagonists of Plasminogen Activator Inhibitor-1: Mechanisms of Action and Therapeutic Potential in Vascular Disease

纤溶酶原激活物抑制剂-1的化学拮抗剂:作用机制及其在血管疾病中的治疗潜力

Simone, Tessa M; Higgins, Stephen P; Higgins, Craig E; Lennartz, Michelle R; Higgins, Paul J

Low Molecular Weight Antagonists of Plasminogen Activator Inhibitor-1: Therapeutic Potential in Cardiovascular Disease

纤溶酶原激活物抑制剂-1的低分子量拮抗剂:在心血管疾病中的治疗潜力

Simone, Tessa M; Higgins, Paul J