Loss of TDP-43 induces synaptic dysfunction that is rescued by UNC13A splice-switching ASOs
TDP-43 缺失会诱发突触功能障碍,而 UNC13A 剪接转换 ASO 可以挽救这一现象
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doi:10.1101/2024.06.20.599684
Matthew J Keuss, Peter Harley, Eugeni Ryadnov, Rachel E Jackson, Matteo Zanovello, Oscar G Wilkins, Simone Barattucci, Puja R Mehta, Marcio G Oliveira, Joanna E Parkes, Aparna Sinha, Andrés F Correa-Sánchez, Peter L Oliver, Elizabeth M C Fisher, Giampietro Schiavo, Mala Shah, Juan Burrone, Pietro Fr