日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

New AAV9 engineered variants with enhanced neurotropism and reduced liver off-targeting in mice and marmosets

新型AAV9工程变体在小鼠和狨猴中表现出增强的神经趋向性和降低的肝脏脱靶效应。

Serena Gea Giannelli ,Mirko Luoni ,Angelo Iannielli ,Jinte Middeldorp ,Ingrid Philippens ,Simone Bido ,Jakob Körbelin ,Vania Broccoli

SETD5 haploinsufficiency affects mitochondrial compartment in neural cells

SETD5 单倍体不足影响神经细胞中的线粒体区室

Mattia Zaghi, Fabiana Longo, Luca Massimino, Alicia Rubio, Simone Bido, Pietro Giuseppe Mazzara, Edoardo Bellini, Federica Banfi, Paola Podini, Francesca Maltecca, Alessio Zippo, Vania Broccoli, Alessandro Sessa0

Scn1a gene reactivation after symptom onset rescues pathological phenotypes in a mouse model of Dravet syndrome

在Dravet综合征小鼠模型中,症状出现后Scn1a基因的重新激活可挽救病理表型。

Nicholas Valassina #,Simone Brusco #,Alessia Salamone,Linda Serra,Mirko Luoni,Serena Giannelli,Simone Bido,Luca Massimino,Federica Ungaro,Pietro Giuseppe Mazzara,Patrizia D'Adamo,Gabriele Lignani,Vania Broccoli,Gaia Colasante

A SOX2-engineered epigenetic silencer factor represses the glioblastoma genetic program and restrains tumor development

SOX2基因工程改造的表观遗传沉默因子抑制胶质母细胞瘤的基因表达程序,从而抑制肿瘤发展。

Valerio Benedetti ,Federica Banfi ,Mattia Zaghi ,Raquel Moll-Diaz ,Luca Massimino ,Laura Argelich ,Edoardo Bellini ,Simone Bido ,Sharon Muggeo ,Gabriele Ordazzo ,Giuseppina Mastrototaro ,Matteo Moneta ,Alessandro Sessa ,Vania Broccoli

Microglia-specific overexpression of α-synuclein leads to severe dopaminergic neurodegeneration by phagocytic exhaustion and oxidative toxicity

小胶质细胞特异性 α-突触核蛋白过度表达通过吞噬细胞衰竭和氧化毒性导致严重的多巴胺能神经变性

Simone Bido, Sharon Muggeo, Luca Massimino, Matteo Jacopo Marzi, Serena Gea Giannelli, Elena Melacini, Melania Nannoni, Diana Gambarè, Edoardo Bellini, Gabriele Ordazzo, Greta Rossi, Camilla Maffezzini, Angelo Iannelli, Mirko Luoni, Marco Bacigaluppi, Silvia Gregori, Francesco Nicassio, Vania Brocco

dCas9-Based Scn1a Gene Activation Restores Inhibitory Interneuron Excitability and Attenuates Seizures in Dravet Syndrome Mice

基于 dCas9 的 Scn1a 基因激活可恢复抑制性中间神经元兴奋性并减弱 Dravet 综合征小鼠的癫痫发作

Gaia Colasante, Gabriele Lignani, Simone Brusco, Claudia Di Berardino, Jenna Carpenter, Serena Giannelli, Nicholas Valassina, Simone Bido, Raffaele Ricci, Valerio Castoldi, Silvia Marenna, Timothy Church, Luca Massimino, Giuseppe Morabito, Fabio Benfenati, Stephanie Schorge, Letizia Leocani, Dimitri

Reconstitution of the Human Nigro-striatal Pathway on-a-Chip Reveals OPA1-Dependent Mitochondrial Defects and Loss of Dopaminergic Synapses

芯片上重建人类黑质纹状体通路揭示了OPA1依赖性线粒体缺陷和多巴胺能突触丢失

Angelo Iannielli ,Giovanni Stefano Ugolini ,Chiara Cordiglieri ,Simone Bido ,Alicia Rubio ,Gaia Colasante ,Marco Valtorta ,Tommaso Cabassi ,Marco Rasponi ,Vania Broccoli

AAV-PHP.B-Mediated Global-Scale Expression in the Mouse Nervous System Enables GBA1 Gene Therapy for Wide Protection from Synucleinopathy

AAV-PHP.B 介导的小鼠神经系统中的全球性表达使 GBA1 基因疗法能够广泛预防突触核蛋白病

Giuseppe Morabito, Serena G Giannelli, Gabriele Ordazzo, Simone Bido, Valerio Castoldi, Marzia Indrigo, Tommaso Cabassi, Stefano Cattaneo, Mirko Luoni, Cinzia Cancellieri, Alessandro Sessa, Marco Bacigaluppi, Stefano Taverna, Letizia Leocani, José L Lanciego, Vania Broccoli

Mitochondrial division inhibitor-1 is neuroprotective in the A53T-α-synuclein rat model of Parkinson's disease

线粒体分裂抑制剂-1 对帕金森病 A53T-α-突触核蛋白大鼠模型具有神经保护作用

Simone Bido, Federico N Soria, Rebecca Z Fan, Erwan Bezard, Kim Tieu

Striatal NELF-mediated RNA polymerase II stalling controls L-dopa induced dyskinesia

纹状体 NELF 介导的 RNA 聚合酶 II 停滞控制左旋多巴引起的运动障碍

Matthieu F Bastide, Simone Bido, Nathalie Duteil, Erwan Bézard