日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Differential effects of familial Alzheimer's disease-causing mutations on amyloid precursor protein (APP) trafficking, proteolytic conversion, and synaptogenic activity

家族性阿尔茨海默病致病突变对淀粉样前体蛋白(APP)转运、蛋白水解转化和突触生成活性的差异性影响

Sandra Schilling # ,Ajay Pradhan # ,Amelie Heesch # ,Andrea Helbig ,Kaj Blennow ,Christian Koch ,Lea Bertgen ,Edward H Koo ,Gunnar Brinkmalm ,Henrik Zetterberg ,Stefan Kins # ,Simone Eggert #

APP family member dimeric complexes are formed predominantly in synaptic compartments

APP 家族成员二聚体复合物主要在突触区形成

Sandra Schilling, Alexander August, Mathieu Meleux, Carolin Conradt, Luisa M Tremmel, Sandra Teigler, Virginie Adam, Ulrike C Müller, Edward H Koo, Stefan Kins #, Simone Eggert #

The Rab5 activator RME-6 is required for amyloid precursor protein endocytosis depending on the YTSI motif

Rab5 激活剂 RME-6 是淀粉样蛋白前体蛋白内吞所必需的,具体取决于 YTSI 基序

Simone Eggert, Tomas Gruebl, Ritu Rajender, Carsten Rupp, Bianca Sander, Amelie Heesch, Marius Zimmermann, Sebastian Hoepfner, Hanswalter Zentgraf, Stefan Kins

Rationales and arguments behind the adoption of self-selection of nonprescription medicines in Denmark

丹麦推行非处方药自主选择制度的理由和论据

Jacobsen, Solveig Nordahl; Møller-Jensen, Simone Eggert; Sporrong, Sofia Kälvemark

Dimerization leads to changes in APP (amyloid precursor protein) trafficking mediated by LRP1 and SorLA

二聚化导致 LRP1 和 SorLA 介导的 APP(淀粉样蛋白前体)运输发生变化

Simone Eggert, A C Gonzalez, C Thomas, S Schilling, S M Schwarz, C Tischer, V Adam, P Strecker, V Schmidt, T E Willnow, G Hermey, C U Pietrzik, E H Koo, Stefan Kins

APLP1 Is a Synaptic Cell Adhesion Molecule, Supporting Maintenance of Dendritic Spines and Basal Synaptic Transmission

APLP1 是一种突触细胞粘附分子,支持树突棘的维持和基础突触传递

Sandra Schilling, Annika Mehr, Susann Ludewig, Jonathan Stephan, Marius Zimmermann, Alexander August, Paul Strecker, Martin Korte, Edward H Koo, Ulrike C Müller, Stefan Kins, Simone Eggert

Fe65-PTB2 Dimerization Mimics Fe65-APP Interaction

Fe65-PTB2 二聚化模拟 Fe65-APP 相互作用

Lukas P Feilen, Kevin Haubrich, Paul Strecker, Sabine Probst, Simone Eggert, Gunter Stier, Irmgard Sinning, Uwe Konietzko, Stefan Kins, Bernd Simon, Klemens Wild

Amyloid precursor protein dimerization and synaptogenic function depend on copper binding to the growth factor-like domain

淀粉样蛋白前体二聚化和突触形成功能依赖于铜与生长因子样结构域的结合

Frederik Baumkötter, Nadine Schmidt, Carolyn Vargas, Sandra Schilling, Rebecca Weber, Katja Wagner, Sebastian Fiedler, Wilfried Klug, Jens Radzimanowski, Sebastian Nickolaus, Sandro Keller, Simone Eggert, Klemens Wild, Stefan Kins

Early BDNF treatment ameliorates cell loss in the entorhinal cortex of APP transgenic mice

早期 BDNF 治疗可改善 APP 转基因小鼠内嗅皮质的细胞丢失

Alan H Nagahara, Michael Mateling, Imre Kovacs, Ling Wang, Simone Eggert, Edward Rockenstein, Edward H Koo, Eliezer Masliah, Mark H Tuszynski

APP dimer formation is initiated in the endoplasmic reticulum and differs between APP isoforms

APP 二聚体的形成始于内质网,不同 APP 亚型之间存在差异

Simone Isbert, Katja Wagner, Simone Eggert, Andrea Schweitzer, Gerd Multhaup, Sascha Weggen, Stefan Kins, Claus U Pietrzik