日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

CD4+ T Cells Expressing Viral Proteins Induce HIV-Associated Endothelial Dysfunction and Hypertension Through Interleukin 1α-Mediated Increases in Endothelial NADPH Oxidase 1

表达病毒蛋白的CD4+ T细胞通过白细胞介素1α介导的内皮NADPH氧化酶1增加诱导HIV相关内皮功能障碍和高血压

Taylor C Kress ,Candee T Barris ,Laszlo Kovacs ,Beryl N Khakina ,Coleton R Jordan ,Thiago Bruder-Nascimento ,David W Stepp ,Rodger MacArthur ,Vijay S Patel ,Jie Chen ,Rafal Pacholczyk ,Simone Kennard ,Eric J Belin de Chantemèle

Loss of neurofibromin induces inflammatory macrophage phenotypic switch and retinal neovascularization via GLUT1 activation

神经纤维蛋白的缺失通过激活GLUT1诱导炎症性巨噬细胞表型转换和视网膜新生血管形成。

Yusra Zaidi ,Rebekah Tritz ,Nida Zaidi ,Faisal Nabi ,Syed Adeel H Zaidi ,Abdelhakim Morsy ,Valerie Harris ,Rilee Racine ,Farlyn Z Hudson ,Zsuzsanna Bordan ,Simone Kennard ,Robert Batori ,Yuqing Huo ,Gabor Csanyi ,Eric J Belin de Chantemèle ,Kecheng Lei ,Nicholas M Boulis ,David J Fulton ,Rizwan Hasan Khan ,Ruth B Caldwell ,Brian K Stansfield

12-week Dolutegravir treatment marginally reduces energy expenditure but does not increase body weight or alter vascular function in a murine model of Human Immunodeficiency Virus infection

在人类免疫缺陷病毒感染的小鼠模型中,为期 12 周的多替拉韦治疗可略微降低能量消耗,但不会增加体重或改变血管功能。

Taylor C Kress ,Priscilla Ajala ,Coleton R Jordan ,James Mintz ,Rodger MacArthur ,Simone Kennard ,Galina Antonova ,Eric J Belin de Chantemèle

Selective deficiency in endothelial PTP1B protects from diabetes and endoplasmic reticulum stress-associated endothelial dysfunction via preventing endothelial cell apoptosis

内皮细胞 PTP1B 选择性缺陷可通过预防内皮细胞凋亡来预防糖尿病和内质网应激相关的内皮功能障碍

Samuel Legeay, Pierre Fautrat, J Blake Norman, Galina Antonova, Simone Kennard, Thiago Bruder-Nascimento, Vijay S Patel, Sebastien Faure, Eric J Belin de Chantemèle

TNFα reduces eNOS activity in endothelial cells through serine 116 phosphorylation and Pin1 binding: Confirmation of a direct, inhibitory interaction of Pin1 with eNOS

TNFα 通过丝氨酸 116 磷酸化和 Pin1 结合降低内皮细胞中的 eNOS 活性:证实 Pin1 与 eNOS 存在直接抑制相互作用

Simone Kennard, Ling Ruan, Ryan J Buffett, David Fulton, Richard C Venema

Calcineurin-mediated dephosphorylation of eNOS at serine 116 affects eNOS enzymatic activity indirectly by facilitating c-Src binding and tyrosine 83 phosphorylation

钙调神经磷酸酶介导的 eNOS 116 位丝氨酸去磷酸化通过促进 c-Src 结合和酪氨酸 83 磷酸化间接影响 eNOS 酶活性

Ling Ruan, Christina M Torres, Ryan J Buffett, Simone Kennard, David Fulton, Richard C Venema

Notch2 and Notch3 function together to regulate vascular smooth muscle development

Notch2 和 Notch3 共同调控血管平滑肌发育

Qingqing Wang, Ning Zhao, Simone Kennard, Brenda Lilly

Endothelial cells downregulate apolipoprotein D expression in mural cells through paracrine secretion and Notch signaling

内皮细胞通过旁分泌和 Notch 信号下调壁细胞载脂蛋白 D 的表达

Mohanasundari Pajaniappan, Nancy K Glober, Simone Kennard, Hua Liu, Ning Zhao, Brenda Lilly

NOTCH3 expression is induced in mural cells through an autoregulatory loop that requires endothelial-expressed JAGGED1

NOTCH3 表达在壁细胞中通过自调节回路诱导,该回路需要内皮细胞表达的 JAGGED1

Hua Liu, Simone Kennard, Brenda Lilly

Differential gene expression in a coculture model of angiogenesis reveals modulation of select pathways and a role for Notch signaling

血管生成共培养模型中的差异基因表达揭示了选择性通路的调节和 Notch 信号的作用

Brenda Lilly, Simone Kennard