日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Co-targeting SOS1 enhances the antitumor effects of KRASG12C inhibitors by addressing intrinsic and acquired resistance

共靶向 SOS1 可通过解决内在和获得性耐药性增强 KRASG12C 抑制剂的抗肿瘤作用

Venu Thatikonda #, Hengyu Lyu #, Sabine Jurado, Kaja Kostyrko, Christopher A Bristow, Christoph Albrecht, Donat Alpar, Heribert Arnhof, Oliver Bergner, Karin Bosch, Ningping Feng, Sisi Gao, Daniel Gerlach, Michael Gmachl, Melanie Hinkel, Simone Lieb, Astrid Jeschko, Annette A Machado, Thomas Madensk

Combined KRASG12C and SOS1 inhibition enhances and extends the anti-tumor response in KRASG12C-driven cancers by addressing intrinsic and acquired resistance

KRASG12C 和 SOS1 联合抑制可通过解决内在和获得性耐药性来增强和延长 KRASG12C 驱动癌症的抗肿瘤反应

Venu Thatikonda, Hengyu Lu, Sabine Jurado, Kaja Kostyrko, Christopher A Bristow, Karin Bosch, Ningping Feng, Sisi Gao, Daniel Gerlach, Michael Gmachl, Simone Lieb, Astrid Jeschko, Annette A Machado, Ethan D Marszalek, Mikhila Mahendra, Philipp A Jaeger, Alexey Sorokin, Sandra Strauss, Francesca Trap

STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancers

利用 STAG1 的脆弱性在 STAG2 缺陷型癌症中发挥黏连蛋白合成致死作用

Petra van der Lelij ,Joseph A Newman ,Simone Lieb ,Julian Jude ,Vittorio Katis ,Thomas Hoffmann ,Matthias Hinterndorfer ,Gerd Bader ,Norbert Kraut ,Mark A Pearson ,Jan-Michael Peters ,Johannes Zuber ,Opher Gileadi ,Mark Petronczki

Structure of the helicase core of Werner helicase, a key target in microsatellite instability cancers

沃纳解旋酶的解旋酶核心结构,微卫星不稳定性癌症的关键靶点

Joseph A Newman, Angeline E Gavard, Simone Lieb, Madhwesh C Ravichandran, Katja Hauer, Patrick Werni, Leonhard Geist, Jark Böttcher, John R Engen, Klaus Rumpel, Matthias Samwer, Mark Petronczki, Opher Gileadi

Werner syndrome helicase is a selective vulnerability of microsatellite instability-high tumor cells

沃纳综合征解旋酶是微卫星不稳定性高的肿瘤细胞的选择性脆弱性

Simone Lieb #, Silvia Blaha-Ostermann #, Elisabeth Kamper, Janine Rippka, Cornelia Schwarz, Katharina Ehrenhöfer-Wölfer, Andreas Schlattl, Andreas Wernitznig, Jesse J Lipp, Kota Nagasaka, Petra van der Lelij, Gerd Bader, Minoru Koi, Ajay Goel, Ralph A Neumüller, Jan-Michael Peters, Norbert Kraut, Ma

Triple Angiokinase Inhibitor Nintedanib Directly Inhibits Tumor Cell Growth and Induces Tumor Shrinkage via Blocking Oncogenic Receptor Tyrosine Kinases

三重血管激酶抑制剂尼达尼布通过阻断致癌受体酪氨酸激酶直接抑制肿瘤细胞生长并诱导肿瘤缩小

Frank Hilberg, Ulrike Tontsch-Grunt, Anke Baum, Anh T Le, Robert C Doebele, Simone Lieb, Davide Gianni, Tilman Voss, Pilar Garin-Chesa, Christian Haslinger, Norbert Kraut

Synthetic lethality between the cohesin subunits STAG1 and STAG2 in diverse cancer contexts

黏连蛋白亚基 STAG1 和 STAG2 在不同癌症背景下的合成致死性

Petra van der Lelij, Simone Lieb, Julian Jude, Gordana Wutz, Catarina P Santos, Katrina Falkenberg, Andreas Schlattl, Jozef Ban, Raphaela Schwentner, Thomas Hoffmann, Heinrich Kovar, Francisco X Real, Todd Waldman, Mark A Pearson, Norbert Kraut, Jan-Michael Peters, Johannes Zuber, Mark Petronczki