日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms

解读 LRRK 密码:LRRK1 和 LRRK2 磷酸化不同的 Rab 蛋白,并受多种机制调控

Asad U Malik, Athanasios Karapetsas, Raja S Nirujogi, Sebastian Mathea, Deep Chatterjee, Prosenjit Pal, Pawel Lis, Matthew Taylor, Elena Purlyte, Robert Gourlay, Mark Dorward, Simone Weidlich, Rachel Toth, Nicole K Polinski, Stefan Knapp, Francesca Tonelli, Dario R Alessi

HIF1α-dependent mitophagy facilitates cardiomyoblast differentiation

HIF1α依赖的线粒体自噬促进心肌细胞分化

Jin-Feng Zhao, Catherine E Rodger, George F G Allen, Simone Weidlich, Ian G Ganley

Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability

发现并鉴定了ZUFSP/ZUP1,一种对基因组稳定性至关重要的独特去泛素化酶类别。

Dominika Kwasna ,Syed Arif Abdul Rehman ,Jayaprakash Natarajan ,Stephen Matthews ,Ross Madden ,Virginia De Cesare ,Simone Weidlich ,Satpal Virdee ,Ivan Ahel ,Ian Gibbs-Seymour ,Yogesh Kulathu

DHX15 regulates CMTR1-dependent gene expression and cell proliferation

DHX15 调节 CMTR1 依赖的基因表达和细胞增殖

Francisco Inesta-Vaquera, Viduth K Chaugule, Alison Galloway, Laurel Chandler, Alejandro Rojas-Fernandez, Simone Weidlich, Mark Peggie, Victoria H Cowling

Expansion of DUB functionality generated by alternative isoforms - USP35, a case study

替代异构体产生的 DUB 功能扩展 - USP35,案例研究

Pawel Leznicki, Jayaprakash Natarajan, Gerd Bader, Walter Spevak, Andreas Schlattl, Syed Arif Abdul Rehman, Deepika Pathak, Simone Weidlich, Andreas Zoephel, Marie C Bordone, Nuno L Barbosa-Morais, Guido Boehmelt, Yogesh Kulathu

The DUF1669 domain of FAM83 family proteins anchor casein kinase 1 isoforms

FAM83 家族蛋白的 DUF1669 结构域锚定酪蛋白激酶 1 亚型

Luke J Fulcher, Polyxeni Bozatzi, Theresa Tachie-Menson, Kevin Z L Wu, Timothy D Cummins, Joshua C Bufton, Daniel M Pinkas, Karen Dunbar, Sabin Shrestha, Nicola T Wood, Simone Weidlich, Thomas J Macartney, Joby Varghese, Robert Gourlay, David G Campbell, Kevin S Dingwell, James C Smith, Alex N Bullo

A single MIU motif of MINDY-1 recognizes K48-linked polyubiquitin chains

MINDY-1 的单个 MIU 基序可识别 K48 连接的多泛素链

Yosua Adi Kristariyanto, Syed Arif Abdul Rehman, Simone Weidlich, Axel Knebel, Yogesh Kulathu

Molecular basis of RNA guanine-7 methyltransferase (RNMT) activation by RAM

RAM 激活 RNA 鸟嘌呤-7 甲基转移酶 (RNMT) 的分子基础

Dhaval Varshney, Alain-Pierre Petit, Juan A Bueren-Calabuig, Chimed Jansen, Dan A Fletcher, Mark Peggie, Simone Weidlich, Paul Scullion, Andrei V Pisliakov, Victoria H Cowling

Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma

干细胞中 TGFβ 受体失活导致皮肤鳞状细胞癌

Patrizia Cammareri, Aidan M Rose, David F Vincent, Jun Wang, Ai Nagano, Silvana Libertini, Rachel A Ridgway, Dimitris Athineos, Philip J Coates, Angela McHugh, Celine Pourreyron, Jasbani H S Dayal, Jonas Larsson, Simone Weidlich, Lindsay C Spender, Gopal P Sapkota, Karin J Purdie, Charlotte M Proby,

Casein kinase 2 (CK2) phosphorylates the deubiquitylase OTUB1 at Ser16 to trigger its nuclear localization

酪蛋白激酶 2 (CK2) 在 Ser16 位点磷酸化去泛素化酶 OTUB1,从而触发其核定位

Lina Herhaus, Ana B Perez-Oliva, Giorgio Cozza, Robert Gourlay, Simone Weidlich, David G Campbell, Lorenzo A Pinna, Gopal P Sapkota