日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Protection against prolonged pneumococcal infection involves structural changes in C-reactive protein and subsequent binding to both phosphocholine and amyloids on the bacterial surface.

预防肺炎球菌长期感染涉及 C 反应蛋白的结构变化,以及随后与细菌表面的磷酸胆碱和淀粉样蛋白的结合

Agrawal Alok, Ngwa Donald N, Simons J Paul, Singh Sanjay K

Novel defect in phosphatidylinositol 4-kinase type 2-alpha (PI4K2A) at the membrane-enzyme interface is associated with metabolic cutis laxa

膜酶界面磷脂酰肌醇4-激酶2α型(PI4K2A)的新缺陷与代谢性皮肤松弛症相关

Mohamed, Miski; Gardeitchik, Thatjana; Balasubramaniam, Shanti; Guerrero-Castillo, Sergio; Dalloyaux, Daisy; van Kraaij, Sanne; Venselaar, Hanka; Hoischen, Alexander; Urban, Zsolt; Brandt, Ulrich; Al-Shawi, Raya; Simons, J Paul; Frison, Michele; Ngu, Lock-Hock; Callewaert, Bert; Spelbrink, Hans; Kallemeijn, Wouter W; Aerts, Johannes M F G; Waugh, Mark G; Morava, Eva; Wevers, Ron A

Systemic Exosomal Delivery of shRNA Minicircles Prevents Parkinsonian Pathology

系统性外泌体递送shRNA微环可预防帕金森病理

Izco, María; Blesa, Javier; Schleef, Martin; Schmeer, Marco; Porcari, Riccardo; Al-Shawi, Raya; Ellmerich, Stephan; de Toro, María; Gardiner, Chris; Seow, Yiqi; Reinares-Sebastian, Alejandro; Forcen, Raquel; Simons, J Paul; Bellotti, Vittorio; Cooper, J Mark; Alvarez-Erviti, Lydia

Pharmacological removal of serum amyloid P component from intracerebral plaques and cerebrovascular Aβ amyloid deposits in vivo

体内药理学方法清除脑内斑块和脑血管Aβ淀粉样蛋白沉积物中的血清淀粉样蛋白P成分

Al-Shawi, Raya; Tennent, Glenys A; Millar, David J; Richard-Londt, Angela; Brandner, Sebastian; Werring, David J; Simons, J Paul; Pepys, Mark B

Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway

簇蛋白通过Dickkopf-1驱动的wnt-PCP-JNK通路激活来调控β-淀粉样蛋白毒性。

Killick, R; Ribe, E M; Al-Shawi, R; Malik, B; Hooper, C; Fernandes, C; Dobson, R; Nolan, P M; Lourdusamy, A; Furney, S; Lin, K; Breen, G; Wroe, R; To, A W M; Leroy, K; Causevic, M; Usardi, A; Robinson, M; Noble, W; Williamson, R; Lunnon, K; Kellie, S; Reynolds, C H; Bazenet, C; Hodges, A; Brion, J-P; Stephenson, J; Simons, J Paul; Lovestone, Simon

Targeted In Situ Gene Correction of Dysfunctional APOE Alleles to Produce Atheroprotective Plasma ApoE3 Protein

通过靶向原位基因校正功能异常的APOE等位基因,产生具有抗动脉粥样硬化作用的血浆ApoE3蛋白。

Papaioannou, Ioannis; Simons, J Paul; Owen, James S

Overexpression of 5-HT2C receptors in forebrain leads to elevated anxiety and hypoactivity

前脑中5-HT2C受体的过度表达会导致焦虑加剧和活动减少。

Kimura, Atsuko; Stevenson, Paula L; Carter, Roderick N; Maccoll, Gavin; French, Karen L; Simons, J Paul; Al-Shawi, Raya; Kelly, Valerie; Chapman, Karen E; Holmes, Megan C