日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Archetypal transcriptional blocks underpin yeast gene regulation in response to changes in growth conditions

典型的转录模块是酵母基因调控响应生长条件变化的基础。

Talavera, David; Kershaw, Christopher J; Costello, Joseph L; Castelli, Lydia M; Rowe, William; Sims, Paul F G; Ashe, Mark P; Grant, Chris M; Pavitt, Graham D; Hubbard, Simon J

Direct and Absolute Quantification of over 1800 Yeast Proteins via Selected Reaction Monitoring

利用选择反应监测技术直接和绝对定量超过1800种酵母蛋白

Lawless, Craig; Holman, Stephen W; Brownridge, Philip; Lanthaler, Karin; Harman, Victoria M; Watkins, Rachel; Hammond, Dean E; Miller, Rebecca L; Sims, Paul F G; Grant, Christopher M; Eyers, Claire E; Beynon, Robert J; Hubbard, Simon J

The yeast La related protein Slf1p is a key activator of translation during the oxidative stress response

酵母La相关蛋白Slf1p是氧化应激反应过程中翻译的关键激活因子

Kershaw, Christopher J; Costello, Joseph L; Castelli, Lydia M; Talavera, David; Rowe, William; Sims, Paul F G; Ashe, Mark P; Hubbard, Simon J; Pavitt, Graham D; Grant, Chris M

A mass spectrometric strategy for absolute quantification of Plasmodium falciparum proteins of low abundance.

一种用于对低丰度恶性疟原虫蛋白进行绝对定量分析的质谱策略

Southworth Paul M, Hyde John E, Sims Paul F G

Dynamic subcellular localization of isoforms of the folate pathway enzyme serine hydroxymethyltransferase (SHMT) through the erythrocytic cycle of Plasmodium falciparum

恶性疟原虫红细胞周期中叶酸代谢途径酶丝氨酸羟甲基转移酶 (SHMT) 同工酶的动态亚细胞定位

Read, Martin; Müller, Ingrid B; Mitchell, Sarah L; Sims, Paul F G; Hyde, John E

A protein-centric approach for the identification of folate enzymes from the malarial parasite, Plasmodium falciparum, using OFFGEL™ solution-based isoelectric focussing and mass spectrometry.

利用 OFFGEL™ 溶液等电聚焦和质谱技术,以蛋白质为中心的方法鉴定疟原虫(恶性疟原虫)中的叶酸酶

O'Cualain Ronan D M, Hyde John E, Sims Paul F G

Fusel alcohols regulate translation initiation by inhibiting eIF2B to reduce ternary complex in a mechanism that may involve altering the integrity and dynamics of the eIF2B body

杂醇油通过抑制eIF2B来调节翻译起始,从而减少三元复合物的形成,其机制可能涉及改变eIF2B复合物的完整性和动态性。

Taylor, Eleanor J; Campbell, Susan G; Griffiths, Christian D; Reid, Peter J; Slaven, John W; Harrison, Richard J; Sims, Paul F G; Pavitt, Graham D; Delneri, Daniela; Ashe, Mark P

Characterisation of the bifunctional dihydrofolate synthase-folylpolyglutamate synthase from Plasmodium falciparum; a potential novel target for antimalarial antifolate inhibition

恶性疟原虫双功能二氢叶酸合成酶-叶酰多谷氨酸合成酶的特性分析;抗疟抗叶酸抑制剂的潜在新靶点

Wang, Ping; Wang, Qi; Yang, Yonghong; Coward, James K; Nzila, Alexis; Sims, Paul F G; Hyde, John E

Plasmodium falciparum: a paradigm for alternative folate biosynthesis in diverse microorganisms?

恶性疟原虫:多种微生物中替代性叶酸生物合成的范例?

Hyde, John E; Dittrich, Sabine; Wang, Ping; Sims, Paul F G; de Crécy-Lagard, Valérie; Hanson, Andrew D

An atypical orthologue of 6-pyruvoyltetrahydropterin synthase can provide the missing link in the folate biosynthesis pathway of malaria parasites

6-丙酮酰四氢蝶呤合酶的非典型直系同源物可以提供疟原虫叶酸生物合成途径中缺失的一环。

Dittrich, Sabine; Mitchell, Sarah L; Blagborough, Andrew M; Wang, Qi; Wang, Ping; Sims, Paul F G; Hyde, John E