日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Novel Noncatalytic Substrate-Selective p38α-Specific MAPK Inhibitors with Endothelial-Stabilizing and Anti-Inflammatory Activity

新型非催化底物选择性p38α特异性MAPK抑制剂,具有内皮稳定和抗炎活性

Shah, Nirav G; Tulapurkar, Mohan E; Ramarathnam, Aparna; Brophy, Amanda; Martinez, Ramon 3rd; Hom, Kellie; Hodges, Theresa; Samadani, Ramin; Singh, Ishwar S; MacKerell, Alexander D Jr; Shapiro, Paul; Hasday, Jeffrey D

Shifts in temperature within the physiologic range modify strand-specific expression of select human microRNAs.

生理范围内的温度变化会改变某些人类microRNA的链特异性表达

Potla Ratnakar, Singh Ishwar S, Atamas Sergei P, Hasday Jeffrey D

Polymorphisms in human heat shock factor-1 and analysis of potential biological consequences

人类热休克因子-1的多态性及其潜在生物学后果分析

Bridges, Tiffany M; Scheraga, Rachel G; Tulapurkar, Mohan E; Suffredini, Dante; Liggett, Stephen B; Ramarathnam, Aparna; Potla, Ratnakar; Singh, Ishwar S; Hasday, Jeffrey D

Hyperthermia promotes and prevents respiratory epithelial apoptosis through distinct mechanisms

高热通过不同的机制促进和抑制呼吸道上皮细胞凋亡。

Nagarsekar, Ashish; Tulapurkar, Mohan E; Singh, Ishwar S; Atamas, Sergei P; Shah, Nirav G; Hasday, Jeffrey D

Febrile-range hyperthermia modifies endothelial and neutrophilic functions to promote extravasation.

发热范围内的体温过高会改变内皮细胞和中性粒细胞的功能,从而促进血管外渗

Tulapurkar Mohan E, Almutairy Eid A, Shah Nirav G, He Ju-ren, Puche Adam C, Shapiro Paul, Singh Ishwar S, Hasday Jeffrey D

Distinct, gene-specific effect of heat shock on heat shock factor-1 recruitment and gene expression of CXC chemokine genes

热休克对热休克因子-1募集和CXC趋化因子基因表达具有独特的、基因特异性的影响

Maity, Tapan K; Henry, Michael M; Tulapurkar, Mohan E; Shah, Nirav G; Hasday, Jeffrey D; Singh, Ishwar S

Response of mice to continuous 5-day passive hyperthermia resembles human heat acclimation.

小鼠对连续 5 天被动高温的反应类似于人类的热适应

Sareh Houtan, Tulapurkar Mohan E, Shah Nirav G, Singh Ishwar S, Hasday Jeffrey D

Core temperature correlates with expression of selected stress and immunomodulatory genes in febrile patients with sepsis and noninfectious SIRS

在脓毒症和非感染性全身炎症反应综合征(SIRS)发热患者中,核心体温与特定应激和免疫调节基因的表达相关。

Sonna, Larry A; Hawkins, Lauren; Lissauer, Matthew E; Maldeis, Pam; Towns, Michael; Johnson, Steven B; Moore, Richard; Singh, Ishwar S; Cowan, Mark J; Hasday, Jeffrey D

Hyperthermia in the febrile range induces HSP72 expression proportional to exposure temperature but not to HSF-1 DNA-binding activity in human lung epithelial A549 cells

在发热范围内,体温过高可诱导人肺上皮A549细胞中HSP72的表达,且表达量与暴露温度成正比,但与HSF-1 DNA结合活性无关。

Tulapurkar, Mohan E; Asiegbu, Benedict E; Singh, Ishwar S; Hasday, Jeffrey D

Heat shock co-activates interleukin-8 transcription.

热休克可协同激活白细胞介素-8的转录

Singh Ishwar S, Gupta Aditi, Nagarsekar Ashish, Cooper Zachary, Manka Cheu, Hester Lisa, Benjamin Ivor J, He Ju-Ren, Hasday Jeffrey D