日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

cGAS inhibition delays TDP-43-driven ALS Pathogenesis

cGAS抑制可延缓TDP-43驱动的ALS发病机制

Liu, Yajing; Feng, Weixi; Aikedan, Abulimiti; Lee, Se-In; Bhagwat, Maitreyee; Nagiri, Ravi Kumar; Wong, Man Ying; Amin, Sadaf; Qu, Wenhui; Zhu, Jingjie; Wang, Si-Yu; Ye, Pearly; Norman, Kendra; Coronas-Samano, Guillermo; Olah, Marta; Tilgner, Hagen U; Fan, Li; Sinha, Subhash C; Gan, Li

cGAS-mediated IFN-I signaling contributes to disease progression in drug-refractory epilepsy.

cGAS介导的I型干扰素信号传导促进药物难治性癫痫的疾病进展。

Huang Yige, Fan Li, Wong Man Ying, Lei Zhuofan, Krishnamachary Balaji, Zhu Daphne, Cadiz Mika, Nagiri Ravi Kumar, Ye Pearly, Norman Kendra, Bhagwat Maitreyee, Lee Young Jae, Li Hui, Zhu Jingjie, Amin Sadaf, Lauderdale Kelli, Chen Hao, Luo Wenjie, Gong Shiaoching, Liechty Benjamin L, Palop Jorge J, Sinha Subhash C, Wu Junfang, Zhao Mingrui, Gan Li

The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway.

APOE3 基因中的 R136S 突变通过抑制 cGAS-STING-IFN 通路赋予机体抵抗 tau 病理的能力

Naguib Sarah, Lopez-Lee Chloe, Torres Eileen Ruth, Lee Se-In, Zhu Jingjie, Zhu Daphne, Ye Pearly, Norman Kendra, Zhao Mingrui, Wong Man Ying, Ambaw Yohannes A, Muñoz-Castañeda Rodrigo, Wang Wei, Patel Tark, Bhagwat Maitreyee, Norinsky Rada, Mok Sue-Ann, Walther Tobias C, Farese Robert V Jr, Luo Wenjie, Sinha Subhash C, Wu Zhuhao, Fan Li, Gong Shiaoching, Gan Li

Identification and development of cGAS inhibitors and their uses to treat Alzheimer's disease

cGAS抑制剂的鉴定和开发及其在治疗阿尔茨海默病中的应用

Alarcón-Espósito, Jazmin; Nagiri, Ravi Kumar; Gan, Li; Sinha, Subhash C

High-Throughput Screening and Initial SAR Studies Identify a Novel Sub-micromolar Potent Human cGAS Inhibitor

高通量筛选和初步构效关系研究发现了一种新型亚微摩尔级强效人cGAS抑制剂

Alarcón-Espósito, Jazmin; Nagiri, Ravi Kumar; Wang, Siyu; Larson, Chloe; Carvallo-Torres, Loreto; Singh, Vipin Kumar; Glickman, Fraser; Gan, Li; Sinha, Subhash C

Boolean Network Modeling Identifies Cognitive Resilience in the First Murine Model of Asymptomatic Alzheimer's Disease

布尔网络建模在首个无症状阿尔茨海默病小鼠模型中识别出认知韧性

Jati, Suborno; Taheri, Sahar; Kal, Satadeepa; Sinha, Subhash C; Head, Brian P; Mahata, Sushil K; Sahoo, Debashis

Tlr7 drives sex differences in age- and Alzheimer's disease-related demyelination.

Tlr7 驱动与年龄和阿尔茨海默病相关的脱髓鞘的性别差异

Lopez-Lee Chloe, Kodama Lay, Fan Li, Zhu Daphne, Zhu Jingjie, Wong Man Ying, Ye Pearly, Norman Kendra, Foxe Nessa R, Ijaz Laraib, Yu Fangmin, Chen Hao, Carling Gillian K, Torres Eileen R, Kim Rachel D, Dubal Dena B, Liddelow Shane A, Sinha Subhash C, Luo Wenjie, Gan Li

Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model.

阿尔茨海默病相关风险等位基因在 tau 蛋白病模型中加剧小胶质细胞 cGAS 相关的衰老和神经退行性变

Carling Gillian K, Fan Li, Foxe Nessa R, Norman Kendra, Wong Man Ying, Zhu Daphne, Corona Carlo, Razzoli Agnese, Yu Fangmin, Yarahmady Allan, Ye Pearly, Chen Hao, Huang Yige, Amin Sadaf, Sereda Rebecca, Lopez-Lee Chloe, Zacharioudakis Emmanouil, Chen Xiaoying, Xu Jielin, Cheng Feixiong, Gavathiotis Evripidis, Cuervo Ana Maria, Holtzman David M, Mok Sue-Ann, Sinha Subhash C, Sidoli Simone, Ratan Rajiv R, Luo Wenjie, Gong Shiaoching, Gan Li

A cell autonomous regulator of neuronal excitability modulates tau in Alzheimer's disease vulnerable neurons

一种细胞自主调节神经元兴奋性的因子可以调节阿尔茨海默病易感神经元中的tau蛋白。

Rodriguez-Rodriguez, Patricia; Arroyo-Garcia, Luis Enrique; Tsagkogianni, Christina; Li, Lechuan; Wang, Wei; Végvári, Ákos; Salas-Allende, Isabella; Plautz, Zakary; Cedazo-Minguez, Angel; Sinha, Subhash C; Troyanskaya, Olga; Flajolet, Marc; Yao, Vicky; Roussarie, Jean-Pierre

Editorial: Spotlight on North America - chemical sciences

社论:聚焦北美——化学科学

Sinha, Subhash C; Ummadisetti, Chinna Rajesh; Laali, Kenneth K; Bao, Kai; Bhupathiraju, Naga V S D K; Ojima, Iwao