日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A palmitoyl transferase chemical-genetic system to map ZDHHC-specific S-acylation

利用棕榈酰转移酶化学遗传系统绘制 ZDHHC 特异性 S-酰化图谱

Cory A Ocasio # ,Marc P Baggelaar # ,James Sipthorp # ,Ana Losada de la Lastra ,Manuel Tavares ,Jana Volarić ,Christelle Soudy ,Elisabeth M Storck ,Jack W Houghton ,Susana A Palma-Duran ,James I MacRae ,Goran Tomić ,Lotte Carr ,Julian Downward ,Ulrike S Eggert ,Edward W Tate

Pharmacokinetics and safety of topical fluralaner in koalas (Phascolarctos cinereus )

氟雷拉纳局部用药在考拉(Phascolarctos cinereus)体内的药代动力学和安全性

Young, Ellyssia T; McKelson, Jessica; Kalstrom, Daniel; Sipthorp, Lachlan; Wicker, Leanne; Higgins, Damien; Marschner, Caroline; Nichols, David S; Phalen, David; Greenville, Aaron C; Carver, Scott

Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit

通过优化晶体片段匹配设计一种强效、选择性、可渗透脑的 Wnt 失活酶 Notum 抑制剂

Nicky J Willis, William Mahy, James Sipthorp, Yuguang Zhao, Hannah L Woodward, Benjamin N Atkinson, Elliott D Bayle, Fredrik Svensson, Sarah Frew, Fiona Jeganathan, Amy Monaghan, Stefano Benvegnù, Sarah Jolly, Luca Vecchia, Reinis R Ruza, Svend Kjær, Steven Howell, Ambrosius P Snijders, Magda Bictas

CLICK-enabled analogues reveal pregnenolone interactomes in cancer and immune cells

CLICK 类似物揭示了孕烯醇酮在癌细胞和免疫细胞中的相互作用组

Roy, Sougata; Sipthorp, James; Mahata, Bidesh; Pramanik, Jhuma; Hennrich, Marco L; Gavin, Anne-Claude; Ley, Steven V; Teichmann, Sarah A

Scaffold-hopping identifies furano[2,3-d]pyrimidine amides as potent Notum inhibitors

骨架跃迁法鉴定出呋喃并[2,3-d]嘧啶酰胺是有效的Notum抑制剂

Atkinson, Benjamin N; Steadman, David; Mahy, William; Zhao, Yuguang; Sipthorp, James; Bayle, Elliott D; Svensson, Fredrik; Papageorgiou, George; Jeganathan, Fiona; Frew, Sarah; Monaghan, Amy; Bictash, Magda; Jones, E Yvonne; Fish, Paul V

Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen

通过X射线碎片筛选发现2-苯氧基乙酰胺类化合物可作为Wnt脱棕榈油酶NOTUM的抑制剂。

Atkinson, Benjamin N; Steadman, David; Zhao, Yuguang; Sipthorp, James; Vecchia, Luca; Ruza, Reinis R; Jeganathan, Fiona; Lines, Georgie; Frew, Sarah; Monaghan, Amy; Kjær, Svend; Bictash, Magda; Jones, E Yvonne; Fish, Paul V

Visualization of Endogenous ERK1/2 in Cells with a Bioorthogonal Covalent Probe

使用生物正交共价探针可视化细胞中的内源性 ERK1/2

James Sipthorp, Honorine Lebraud, Rebecca Gilley, Andrew M Kidger, Hanneke Okkenhaug, Marc Saba-El-Leil, Sylvain Meloche, Christopher J Caunt, Simon J Cook, Tom D Heightman

A New Methodology for Incorporating Chiral Linkers into Stapled Peptides

将手性连接基团引入交联肽的新方法

Serrano, Juan C; Sipthorp, James; Xu, Wenshu; Itzhaki, Laura S; Ley, Steven V