日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Tissue-resident macrophage survival depends on mitochondrial function regulated by SerpinB2 in chronic inflammation.

组织驻留巨噬细胞的存活依赖于线粒体功能,而线粒体功能在慢性炎症中受 SerpinB2 调控。

Vasamsetti Sathish Babu, Sadaf Samreen, Uddin Mohammad A, Shen Jixing, Johny Ebin, Mondal Awishi, Florentin Jonathan, Lei Liqun, Mannan Aleef, Rao Krithika Sudhakar, Sembrat John, Rojas Mauricio, Sipula Ian, Kastroll Jake, Jurczak Michael J, Shiva Sruti, O'Doherty Robert M, Yechoor Vijay, Dutta Partha

Benefits of oral nitrite supplementation on mitochondrial respiration and physical function in older adults

口服亚硝酸盐补充剂对老年人线粒体呼吸和身体机能的益处

Forman, Daniel E; Perera, Subashan; Shiva, Sruti; Glynn, Nancy W; Stakich, Tara S; Ramos, Sofhia V; Distefano, Giovanna; Wolf, Cody; Kendi, Angelina; Sterczala, Adam J; Sipula, Ian J; Bello, Fiona M; Jurczak, Michael J; Sciurba, Frank C; Gladwin, Mark T; Newman, Anne B; Coen, Paul M

Dietary methionine restriction started late in life promotes healthy aging in a sex-specific manner.

晚年开始限制膳食蛋氨酸摄入可以促进健康老龄化,且这种促进作用具有性别特异性

Hernández-Arciga Ulalume, Stamenkovic Ceda, Yadav Shweta, Nicoletti Chiara, Albalawy Wafaa N, Al Hammood Farazdaq, Gonzalez Tiffany Fuentes, Naikwadi Maitreyi U, Graham Aidan, Smarz Christian, Little Gabriela J, Williams Sean-Paul G, McMahon Brenda, Sipula Ian J, Vandevender Amber M, Chuan Byron, Cooke Diana, Pinto Antonio F M, Flores Lisa C, Hartman Hannah L, Diedrich Jolene K, Brooke Robert T, Alder Jonathan K, Frahm Krystle A, Pascal Laura E, Stolt Emma, Troensegaard Hannibal, Øvrebø Bente, Elshorbagy Amany, Molina Elsa, Vinknes Kathrine J, Tan Roderick J, Weisz Ora A, Bueno Marta, Eickelberg Oliver, Steinhauser Matthew L, Finkel Toren, Ables Gene P, Ikeno Yuji, Olsen Thomas, Sacco Alessandra, Jurczak Michael J, Sukoff Rizzo Stacey J, Parkhitko Andrey A

Mutation in IR or IGF1R produces features of long-lived mice while maintaining metabolic health

IR或IGF1R基因突变可使小鼠表现出长寿的特征,同时维持其代谢健康。

Hernández-Arciga, Ulalume; Kim, Jun Kyoung; Fisher, Jacob L; Tyshkovskiy, Alexander; Moldakozhayev, Alibek; Hall, Catherine; Ghosh, Souvik; Govindaraj, Yashvandhini; Sipula, Ian J; Kastroll, Jake; Cooke, Diana; Luo, Jinping; Alder, Jonathan K; Rizzo, Stacey J Sukoff; Ables, Gene P; Choi, Eunhee; Gladyshev, Vadim N; Jurczak, Michael J; Tatar, Marc; Parkhitko, Andrey A

Skeletal muscle mitochondrial dysfunction is associated with increased Gdf15 expression and circulating GDF15 levels in aged mice.

老年小鼠骨骼肌线粒体功能障碍与 Gdf15 表达增加和循环 GDF15 水平升高有关

Chen J, Kastroll J, Bello F M, Pangburn M M, Murali A, Smith P M, Rychcik K, Loughridge K E, Vandevender A M, Dedousis N, Sipula I J, Alder J K, Jurczak M J

Role of Cardiorespiratory Fitness and Mitochondrial Oxidative Capacity in Reduced Walk Speed of Older Adults With Diabetes

心肺功能和线粒体氧化能力在老年糖尿病患者步行速度减慢中的作用

Ramos, Sofhia V; Distefano, Giovanna; Lui, Li-Yung; Cawthon, Peggy M; Kramer, Philip; Sipula, Ian J; Bello, Fiona M; Mau, Theresa; Jurczak, Michael J; Molina, Anthony J; Kershaw, Erin E; Marcinek, David J; Shankland, Eric; Toledo, Frederico G S; Newman, Anne B; Hepple, Russell T; Kritchevsky, Stephen B; Goodpaster, Bret H; Cummings, Steven R; Coen, Paul M

Inhibitory protein-protein interactions of the SIRT1 deacetylase are choreographed by post-translational modification

SIRT1 去乙酰化酶的抑制蛋白质-蛋白质相互作用由翻译后修饰控制

Troy C Krzysiak, You-Jin Choi, Yong Joon Kim, Yunhan Yang, Christopher DeHaven, Lariah Thompson, Ryan Ponticelli, Mara M Mermigos, Laurel Thomas, Andrea Marquez, Ian Sipula, Jongsook Kim Kemper, Michael Jurczak, Gary Thomas, Angela M Gronenborn

Epigenetic regulation of global proteostasis dynamics by RBBP5 ensures mammalian organismal health

RBBP5 对整体蛋白质稳态动力学的表观遗传调控确保了哺乳动物有机体的健康

Syeda Kubra, Michelle Sun, William Dion, Ahmet Catak, Hannah Luong, Haokun Wang, Yinghong Pan, Jia-Jun Liu, Aishwarya Ponna, Ian Sipula, Michael J Jurczak, Silvia Liu, Bokai Zhu

Megalin Knockout Reduces SGLT2 Expression and Sensitizes to Western Diet-induced Kidney Injury

Megalin 基因敲除可降低 SGLT2 表达并对西方饮食引起的肾损伤敏感

Elynna B Youm, Katherine E Shipman, Wafaa N Albalawy, Amber M Vandevender, Ian J Sipula, Youssef Rbaibi, Allison E Marciszyn, Jared A Lashway, Emma E Brown, Corry B Bondi, Cary R Boyd-Shiwarski, Roderick J Tan, Michael J Jurczak, Ora A Weisz

Reduced mitophagy is an early feature of NAFLD and liver-specific PARKIN knockout hastens the onset of steatosis, inflammation and fibrosis

线粒体自噬减少是NAFLD的早期特征,而肝脏特异性PARKIN基因敲除会加速脂肪变性、炎症和纤维化的发生。

Undamatla, R; Fagunloye, O G; Chen, J; Edmunds, L R; Murali, A; Mills, A; Xie, B; Pangburn, M M; Sipula, I; Gibson, G; St Croix, C; Jurczak, M J