日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Lopinavir Derivative as Potent P-gp Inhibitor Enables Delivery through HPMA Copolymer Conjugates and Overcoming Tumor Chemoresistance to Conventional Cytostatic Drugs

洛匹那韦衍生物作为强效P-gp抑制剂,可通过HPMA共聚物偶联物递送,克服肿瘤对传统细胞抑制剂的化疗耐药性。

Starenko, Daniil; Kostka, Libor; Behalova, Katerina; Kotrchova, Lenka; Subr, Vladimir; Kovarova, Jirina; Roubalova, Radka; Sirova, Milada; Etrych, Tomas; Kovar, Marek

Temporal optimization of CD25-biased IL-2 agonists and immune checkpoint blockade leads to synergistic anticancer activity despite robust regulatory T cell expansion

CD25偏向性IL-2激动剂和免疫检查点阻断剂的时间优化,即使在调节性T细胞大量扩增的情况下,也能产生协同抗癌活性。

Kilic, Irfan Baki; Weberova, Petra; VanDyke, Derek; Sirova, Milada; Kubesova, Katerina; Fabilane, Charina S; Mazhara, Vladyslav; Liu, Kathy; Behalova, Katerina; Ptacek, Bohumil; Rihova, Blanka; Spangler, Jamie B; Kovar, Marek

Novel PD-1-targeted, activity-optimized IL-15 mutein SOT201 acting in cis provides antitumor activity superior to PD1-IL2v.

新型 PD-1 靶向、活性优化的 IL-15 突变体 SOT201 以顺式作用提供优于 PD1-IL2v 的抗肿瘤活性

Matuskova Hana, Marasek Pavel, Mazhara Vladyslav, Simonova Ekaterina, Kosinova Lucie, Danek Petr, Danova Klara, Sajnerova Katerina, Malatova Iva, Hrabankova Klara, Greco Denise, Martinec Ondrej, Fabisik Matej, Podzimkova Nada, Hladikova Kamila, Behalova Katerina, Antosova Zuzana, Sirova Milada, Mikyskova Romana, Reinis Milan, Kovar Marek, Béchard David, Moebius Ulrich, Palova Jelinkova Lenka, Spisek Radek, Steegmaier Martin, Adkins Irena

PLUS-IS-LESS project: Procalcitonin and Lung UltraSonography-based antibiotherapy in patients with Lower rESpiratory tract infection in Swiss Emergency Departments: study protocol for a pragmatic stepped-wedge cluster-randomized trial

PLUS-IS-LESS 项目:瑞士急诊科下呼吸道感染患者中基于降钙素原和肺超声的抗生素治疗:实用阶梯式楔形集群随机试验的研究方案

Cécile Bessat, Roland Bingisser, Markus Schwendinger, Tim Bulaty, Yvan Fournier, Vincent Della Santa, Magali Pfeil, Dominique Schwab, Jörg D Leuppi, Nicolas Geigy, Stephan Steuer, Friedemann Roos, Michael Christ, Adriana Sirova, Tanguy Espejo, Henk Riedel, Alexandra Atzl, Fabian Napieralski, Joachim

SOT101 induces NK cell cytotoxicity and potentiates antibody-dependent cell cytotoxicity and anti-tumor activity

SOT101 诱导 NK 细胞毒性并增强抗体依赖性细胞毒性和抗肿瘤活性

Zuzana Antosova, Nada Podzimkova, Jakub Tomala, Katerina Augustynkova, Katerina Sajnerova, Eva Nedvedova, Milada Sirova, Guy de Martynoff, David Bechard, Ulrich Moebius, Marek Kovar, Radek Spisek, Irena Adkins

Acute and Chronic Sleep Deprivation-Related Changes in N-methyl-D-aspartate Receptor-Nitric Oxide Signalling in the Rat Cerebral Cortex with Reference to Aging and Brain Lateralization

急性及慢性睡眠剥夺对大鼠大脑皮层N-甲基-D-天冬氨酸受体-一氧化氮信号通路的影响及其与衰老和脑侧化的关系

Kristofikova, Zdenka; Sirova, Jana; Klaschka, Jan; Ovsepian, Saak V

Type 1 Sodium Calcium Exchanger Forms a Complex with Carbonic Anhydrase IX and Via Reverse Mode Activity Contributes to pH Control in Hypoxic Tumors

型钠钙交换器与碳酸酐酶 IX 形成复合物,并通过逆向模式活性促进缺氧肿瘤中的 pH 控制

Veronika Liskova, Sona Hudecova, Lubomira Lencesova, Filippo Iuliano, Marta Sirova, Karol Ondrias, Silvia Pastorekova, Olga Krizanova

A Rat Model of Alzheimer's Disease Based on Abeta42 and Pro-oxidative Substances Exhibits Cognitive Deficit and Alterations in Glutamatergic and Cholinergic Neurotransmitter Systems

基于Aβ42和促氧化物质的阿尔茨海默病大鼠模型表现出认知缺陷以及谷氨酸能和胆碱能神经递质系统的改变。

Petrasek, Tomas; Skurlova, Martina; Maleninska, Kristyna; Vojtechova, Iveta; Kristofikova, Zdena; Matuskova, Hana; Sirova, Jana; Vales, Karel; Ripova, Daniela; Stuchlik, Ales

Sulforaphane-induced apoptosis involves the type 1 IP3 receptor

萝卜硫素诱导的细胞凋亡与 1 型 IP3 受体有关

Sona Hudecova, Jana Markova, Veronika Simko, Lucia Csaderova, Tibor Stracina, Marta Sirova, Michaela Fojtu, Eliska Svastova, Paulina Gronesova, Michal Pastorek, Marie Novakova, Dana Cholujova, Juraj Kopacek, Silvia Pastorekova, Jan Sedlak, Olga Krizanova

Treatment with HPMA copolymer-based doxorubicin conjugate containing human immunoglobulin induces long-lasting systemic anti-tumour immunity in mice

使用含有人类免疫球蛋白的 HPMA 共聚物基阿霉素结合物治疗可在小鼠中诱导持久的全身抗肿瘤免疫力

Milada Sirova, Jiri Strohalm, Vladimir Subr, Daniela Plocova, Pavel Rossmann, Tomas Mrkvan, Karel Ulbrich, Blanka Rihova