日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Image-based, pooled phenotyping reveals multidimensional, disease-specific variant effects.

基于图像的汇总表型分析揭示了多维度的、疾病特异性的变异效应

Pendyala Sriram, Partington Katie, Bradley Nicholas, McEwen Abbye E, Straub Gwenneth, Kim Hyeon-Jin, Fayer Shawn, Holmes Daniel Lee, Sitko Katherine A, Vandi Allyssa J, Powell Rachel L, Friedman Clayton E, McDermot Evan, Kishore Nishka, Roth Frederick P, Rubin Alan F, Yang Kai-Chun, Starita Lea M, Noble William S, Fowler Douglas M

Profiling of drug resistance in Src kinase at scale uncovers a regulatory network coupling autoinhibition and catalytic domain dynamics.

大规模分析 Src 激酶的耐药性,揭示了一个将自身抑制和催化结构域动力学耦合起来的调控网络

Chakraborty Sujata, Ahler Ethan, Simon Jessica J, Fang Linglan, Potter Zachary E, Sitko Katherine A, Stephany Jason J, Guttman Miklos, Fowler Douglas M, Maly Dustin J

Deep mutational scanning of CYP2C19 in human cells reveals a substrate specificity-abundance tradeoff.

对人类细胞中 CYP2C19 的深度突变扫描揭示了底物特异性与丰度之间的权衡关系

Boyle Gabriel E, Sitko Katherine A, Galloway Jared G, Haddox Hugh K, Bianchi Aisha Haley, Dixon Ajeya, Wheelock Melinda K, Vandi Allyssa J, Wang Ziyu R, Thomson Raine E S, Garge Riddhiman K, Rettie Allan E, Rubin Alan F, Geck Renee C, Gillam Elizabeth M J, DeWitt William S, Matsen Frederick A 4th, Fowler Douglas M

Molecular determinants of Hsp90 dependence of Src kinase revealed by deep mutational scanning

通过深度突变扫描揭示了Src激酶对Hsp90依赖性的分子决定因素

Nguyen, Vanessa; Ahler, Ethan; Sitko, Katherine A; Stephany, Jason J; Maly, Dustin J; Fowler, Douglas M

Global analysis of condition-specific subcellular protein distribution and abundance

针对特定条件下的亚细胞蛋白分布和丰度进行全局分析

Jung, Sunhee; Smith, Jennifer J; von Haller, Priska D; Dilworth, David J; Sitko, Katherine A; Miller, Leslie R; Saleem, Ramsey A; Goodlett, David R; Aitchison, John D