日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Clinicogenomic Landscape and Function of PIK3CA, AKT1, and PTEN Mutations in Breast Cancer

乳腺癌中PIK3CA、AKT1和PTEN突变的临床基因组图谱和功能

Tao, Jacqueline J; Sisoudiya, Saumya D; Tukachinsky, Hanna; Schrock, Alexa B; Ebot, Ericka M; Sivakumar, Smruthy; Sokol, Ethan S; Vasan, Neil

Cancer genomic profiling predicts pathogenicity of BRCA1 and BRCA2 variants

癌症基因组分析预测BRCA1和BRCA2变异的致病性

Kondrashova, Olga; Johnston, Rebecca L; Parsons, Michael T; Davidson, Aimee L; Canson, Daffodil M; Tran, Khoa A; Cline, Melissa S; Waddell, Nicola; Sivakumar, Smruthy; Sokol, Ethan S; Jin, Dexter X; Pavlick, Dean C; Decker, Brennan; Frampton, Garrett M; Spurdle, Amanda B

Ligand-activated EGFR/MAPK signaling but not PI3K, are key resistance mechanisms to EGFR-therapy in colorectal cancer.

配体激活的 EGFR/MAPK 信号通路(而非 PI3K)是结直肠癌中 EGFR 疗法产生耐药性的关键机制

Qu Xueping, Hamidi Habib, Johnson Radia M, Sokol Ethan S, Lin Eva, Eng Cathy, Kim Tae Won, Bendell Johanna, Sivakumar Smruthy, Kaplan Benjamin, de Sousa E Melo Felipe, Mancini Andrew, Wongchenko Matthew, Shi Yi, Shames David, Yan Yibing, Ciardiello Fortunato, Bais Carlos

Tissue-based genomic profiling of 300,000 tumors highlights the detection of variants with low allele fraction

对 30 万个肿瘤进行基于组织的基因组分析,突显了低等位基因频率变异的检测。

Sisoudiya, Saumya D; Tukachinsky, Hanna; Keller-Evans, Rachel B; Schrock, Alexa B; Huang, Richard S P; Gjoerup, Ole; Pishvaian, Michael J; Shroff, Rachna; Sokol, Ethan S; Dennis, Lucas; Frampton, Garrett M; Sivakumar, Smruthy

Genomic alteration and clinical significance of circulating tumor DNA in patients with advanced urothelial cancer: SCRUM-Japan monstar screen project

晚期尿路上皮癌患者循环肿瘤DNA的基因组改变及其临床意义:SCRUM-Japan monstar筛选项目

Osawa, Takahiro; Matsubara, Nobuaki; Kato, Taigo; Shiota, Masaki; Nishimoto, Koshiro; Abe, Takashige; Shinohara, Nobuo; Yasumizu, Yota; Tanaka, Nobuyuki; Oya, Mototsugu; Abutani, Hikaru; Oda, Takaaki; Fujisawa, Takao; Nakamura, Yoshiaki; Sivakumar, Smruthy; Eto, Masatoshi; Yoshino, Takayuki; Nonomura, Norio

Comprehensive molecular landscape of anal squamous cell carcinoma: analysis of tissue and liquid biopsies from 1844 patients

肛门鳞状细胞癌的全面分子图谱:对1844例患者的组织和液体活检样本的分析

Smolenschi, Cristina; Sisoudiya, Saumya D; Hollebecque, Antoine; Sivakumar, Smruthy; Montesion, Meagan; Euzen, Victor; Boige, Valérie; Boilève, Alice; Valery, Marine; Sourouille, Isabelle; Bayle, Arnaud; Aldea, Mihaela; Rodriguez, Julieta Elena; Gelli, Massimiliano; Dall'Olio, Filippo Gustavo; Tarabay, Anthony; Pudlarz, Thomas; Bahleda, Rastislav; Fuerea, Alina; Benhaim, Léonor; de Sevilla, Elena Fernandez; Bani, Mohamed; Dartigues, Peggy; Pernot, Simon; Boillet, Gautier; Beshiri, Kristi; Massard, Christophe; Friboulet, Luc; Facchinetti, Francesco; Lacroix, Ludovic; Rouleau, Etienne; Barlesi, Fabrice; Ducreux, Michel; Italiano, Antoine; Sharaf, Radwa; Vasseur, Damien

Retrospective comparison between breast cancer tissue- and blood-based next-generation sequencing results in detection of PIK3CA, AKT1, and PTEN alterations

回顾性比较基于乳腺癌组织和血液的二代测序结果,以检测PIK3CA、AKT1和PTEN的改变

Chaki, Moumita; Benrashid, Mona; Puri, Subir; Sivakumar, Smruthy; Sokol, Ethan S; Briceno, Josefa M; Neil Vasan

Clinical Use of Liquid-Based Comprehensive Genomic Profiling in Gastrointestinal Stromal Tumors

液基综合基因组分析在胃肠道间质瘤中的临床应用

Mechahougui, Hiba; Hildebrand, Lindsey; Haberberger, James; Sivakumar, Smruthy; Saiji, Essia; Tukachinsky, Hanna; Madison, Russell; Killian, Jonathan K; Huang, Richard S P; Elvin, Julia A; Marks, Eric; Heinrich, Michael C; Koessler, Thibaud; Lin, Douglas I

Clinicogenomic landscape and function of PIK3CA , AKT1 , and PTEN mutations in breast cancer

乳腺癌中PIK3CA、AKT1和PTEN突变的临床基因组图谱和功能

Tao, Jacqueline J; Sisoudiya, Saumya D; Tukachinsky, Hanna; Schrock, Alexa; Sivakumar, Smruthy; Sokol, Ethan S; Vasan, Neil

U2AF1 mutations rescue deleterious exon skipping induced by KRAS mutations.

U2AF1 突变可挽救 KRAS 突变引起的有害外显子跳跃

Walter David M, Cho Katherine, Sivakumar Smruthy, Lee Iris T-H, Dohlman Anders B, Shurberg Ethan, Jiang Kevin X, Gupta Akansha A, Frampton Garrett M, Meyerson Matthew