Sivakumar Viswanathan相关文献与解析，生知库

Anissa A Widjaja #, Wei-Wen Lim #, Sivakumar Viswanathan, Sonia Chothani, Ben Corden, Cibi Mary Dasan, Joyce Wei Ting Goh, Radiance Lim, Brijesh K Singh, Jessie Tan, Chee Jian Pua, Sze Yun Lim, Eleonora Adami, Sebastian Schafer, Benjamin L George, Mark Sweeney, Chen Xie, Madhulika Tripathi, Natalie

信号转导

发表日期：2024

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Interleukin-11 causes alveolar type 2 cell dysfunction and prevents alveolar regeneration

白细胞介素-11会导致II型肺泡细胞功能障碍并阻碍肺泡再生。

期刊:Nature Communications

影响因子:14.7

doi:10.1038/s41467-024-52810-8

Benjamin Ng ，Kevin Y Huang # ，Chee Jian Pua # ，Sivakumar Viswanathan ，Wei-Wen Lim ，Fathima F Kuthubudeen ，Yu-Ning Liu ，An An Hii ，Benjamin L George ，Anissa A Widjaja ，Enrico Petretto ，Stuart A Cook

细胞生物学

发表日期：2024

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Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease

在急性和慢性肾脏疾病模型中使用抗 IL11 疗法靶向内源性肾脏再生

期刊:Nature Communications

影响因子:14.7

doi:10.1038/s41467-022-35306-1

Anissa A Widjaja #, Sivakumar Viswanathan, Shamini G Shekeran, Eleonora Adami, Wei-Wen Lim, Sonia Chothani, Jessie Tan, Joyce Wei Ting Goh, Hui Mei Chen, Sze Yun Lim, Carine M Boustany-Kari, Julie Hawkins, Enrico Petretto, Norbert Hübner, Sebastian Schafer, Thomas M Coffman, Stuart A Cook #

信号转导

发表日期：2022

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A Neutralizing IL-11 Antibody Improves Renal Function and Increases Lifespan in a Mouse Model of Alport Syndrome

中和 IL-11 抗体可改善 Alport 综合征小鼠模型的肾功能并延长其寿命

期刊:Journal of the American Society of Nephrology

影响因子:10.3

doi:10.1681/ASN.2021040577

Anissa A Widjaja, Shamini G Shekeran, Eleonora Adami, Joyce G Wei Ting, Jessie Tan, Sivakumar Viswanathan, Sze Yun Lim, Puay Hoon Tan, Norbert Hübner, Thomas Coffman, Stuart A Cook

IL11 stimulates ERK/P90RSK to inhibit LKB1/AMPK and activate mTOR initiating a mesenchymal program in stromal, epithelial, and cancer cells

IL11 刺激 ERK/P90RSK 抑制 LKB1/AMPK 并激活 mTOR，从而在基质细胞、上皮细胞和癌细胞中启动间充质程序

期刊:iScience

影响因子:4.6

doi:10.1016/j.isci.2022.104806

Anissa A Widjaja, Sivakumar Viswanathan, Joyce Goh Wei Ting, Jessie Tan, Shamini G Shekeran, David Carling, Wei-Wen Lim, Stuart A Cook

IL11 Stimulates IL33 Expression and Proinflammatory Fibroblast Activation across Tissues

IL11 刺激组织中 IL33 表达和促炎成纤维细胞活化

期刊:International Journal of Molecular Sciences

影响因子:0.7

doi:10.3390/ijms23168900

Anissa A Widjaja, Sonia Chothani, Sivakumar Viswanathan, Joyce Wei Ting Goh, Wei-Wen Lim, Stuart A Cook

IL11 Activates Pancreatic Stellate Cells and Causes Pancreatic Inflammation, Fibrosis and Atrophy in a Mouse Model of Pancreatitis

IL11 激活胰腺星状细胞并在小鼠胰腺炎模型中引起胰腺炎症、纤维化和萎缩

期刊:International Journal of Molecular Sciences

影响因子:0.7

doi:10.3390/ijms23073549

Benjamin Ng, Sivakumar Viswanathan, Anissa A Widjaja, Wei-Wen Lim, Shamini G Shekeran, Joyce Wei Ting Goh, Jessie Tan, Fathima Kuthubudeen, Sze Yun Lim, Chen Xie, Sebastian Schafer, Eleonora Adami, Stuart A Cook

Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH

肝细胞特异性 IL11 顺式信号传导驱动脂肪毒性并成为 NAFLD 向 NASH 转变的基础

期刊:Nature Communications

影响因子:14.7

doi:10.1038/s41467-020-20303-z

Jinrui Dong, Sivakumar Viswanathan, Eleonora Adami, Brijesh K Singh, Sonia P Chothani, Benjamin Ng, Wei Wen Lim, Jin Zhou, Madhulika Tripathi, Nicole S J Ko, Shamini G Shekeran, Jessie Tan, Sze Yun Lim, Mao Wang, Pei Min Lio, Paul M Yen, Sebastian Schafer, Stuart A Cook, Anissa A Widjaja

The pro-regenerative effects of hyperIL6 in drug-induced liver injury are unexpectedly due to competitive inhibition of IL11 signaling

hyperIL6 在药物性肝损伤中的促再生作用意外地归因于对 IL11 信号的竞争性抑制

期刊:Elife

影响因子:6.4

doi:10.7554/eLife.68843

Jinrui Dong, Sivakumar Viswanathan, Eleonora Adami, Sebastian Schafer, Fathima F Kuthubudeen, Anissa A Widjaja, Stuart A Cook

Molecular Dissection of Pro-Fibrotic IL11 Signaling in Cardiac and Pulmonary Fibroblasts

心脏和肺成纤维细胞中促纤维化 IL11 信号的分子解剖

期刊:Frontiers in Molecular Biosciences

影响因子:3.9

doi:10.3389/fmolb.2021.740650

Anissa A Widjaja, Sivakumar Viswanathan, Dong Jinrui, Brijesh K Singh, Jessie Tan, Joyce Goh Wei Ting, David Lamb, Shamini G Shekeran, Benjamin L George, Sebastian Schafer, David Carling, Eleonora Adami, Stuart A Cook

Inhibition of IL-11 signalling extends mammalian healthspan and lifespan

抑制 IL-11 信号可延长哺乳动物的健康寿命和寿命

Interleukin-11 causes alveolar type 2 cell dysfunction and prevents alveolar regeneration

白细胞介素-11会导致II型肺泡细胞功能障碍并阻碍肺泡再生。

Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease

在急性和慢性肾脏疾病模型中使用抗 IL11 疗法靶向内源性肾脏再生

A Neutralizing IL-11 Antibody Improves Renal Function and Increases Lifespan in a Mouse Model of Alport Syndrome

中和 IL-11 抗体可改善 Alport 综合征小鼠模型的肾功能并延长其寿命

IL11 stimulates ERK/P90RSK to inhibit LKB1/AMPK and activate mTOR initiating a mesenchymal program in stromal, epithelial, and cancer cells

IL11 刺激 ERK/P90RSK 抑制 LKB1/AMPK 并激活 mTOR，从而在基质细胞、上皮细胞和癌细胞中启动间充质程序

IL11 Stimulates IL33 Expression and Proinflammatory Fibroblast Activation across Tissues

IL11 刺激组织中 IL33 表达和促炎成纤维细胞活化

IL11 Activates Pancreatic Stellate Cells and Causes Pancreatic Inflammation, Fibrosis and Atrophy in a Mouse Model of Pancreatitis

IL11 激活胰腺星状细胞并在小鼠胰腺炎模型中引起胰腺炎症、纤维化和萎缩

Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH

肝细胞特异性 IL11 顺式信号传导驱动脂肪毒性并成为 NAFLD 向 NASH 转变的基础

The pro-regenerative effects of hyperIL6 in drug-induced liver injury are unexpectedly due to competitive inhibition of IL11 signaling

hyperIL6 在药物性肝损伤中的促再生作用意外地归因于对 IL11 信号的竞争性抑制

Molecular Dissection of Pro-Fibrotic IL11 Signaling in Cardiac and Pulmonary Fibroblasts

心脏和肺成纤维细胞中促纤维化 IL11 信号的分子解剖