Transgenic IGF-IR overexpression induces mammary tumors with basal-like characteristics, whereas IGF-IR-independent mammary tumors express a claudin-low gene signature.

转基因 IGF-IR 过表达可诱导具有基底样特征的乳腺肿瘤，而 IGF-IR 非依赖性乳腺肿瘤则表达 claudin 低表达基因特征