日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

An exocyclic methylene group acts as a bioisostere of the 2'-oxygen atom in LNA

环外亚甲基作为LNA中2'-氧原子的生物等排体。

期刊:Journal of the American Chemical Society
影响因子:15.6
doi:10.1021/ja105875e
Seth, Punit P; Allerson, Charles R; Berdeja, Andres; Siwkowski, Andrew; Pallan, Pradeep S; Gaus, Hans; Prakash, Thazha P; Watt, Andrew T; Egli, Martin; Swayze, Eric E
发表日期：2010
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Peptide nucleic acids conjugated to short basic peptides show improved pharmacokinetics and antisense activity in adipose tissue

与短碱性肽偶联的肽核酸在脂肪组织中表现出改善的药代动力学和反义活性。

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/jm901489k
Wancewicz, Edward V; Maier, Martin A; Siwkowski, Andrew M; Albertshofer, Klaus; Winger, Theodore M; Berdeja, Andres; Gaus, Hans; Vickers, Timothy A; Bennett, C Frank; Monia, Brett P; Griffey, Richard H; Nulf, Christopher J; Hu, Jiaxin; Corey, David R; Swayze, Eric E; Kinberger, Garth A
发表日期：2010
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Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals

含有锁核酸的反义寡核苷酸可提高药效，但会导致动物出现显著的肝毒性。

期刊:Nucleic Acids Research
影响因子:13.1
doi:10.1093/nar/gkl1071
Swayze, Eric E; Siwkowski, Andrew M; Wancewicz, Edward V; Migawa, Michael T; Wyrzykiewicz, Tadeusz K; Hung, Gene; Monia, Brett P; Bennett, C Frank
毒理研究
发表日期：2007
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Identification and functional validation of PNAs that inhibit murine CD40 expression by redirection of splicing

通过重定向剪接来抑制小鼠 CD40 表达的 PNA 的鉴定和功能验证

期刊:Nucleic Acids Research
影响因子:16.6
doi:10.1093/nar/gkh584
Andrew M Siwkowski, Leila Malik, Christine C Esau, Martin A Maier, Edward V Wancewicz, Klaus Albertshofer, Brett P Monia, C Frank Bennett, Anne B Eldrup
细胞生物学
发表日期：2004
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