日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Profiling BRCA1-BRCT interactions and their functional relevance at amino acid resolution

在氨基酸分辨率下分析BRCA1-BRCT相互作用及其功能相关性

Venda Mangkusaputra,Andrea G Murachelli,Zhengzhou Yu,Annouche den Hollander,Roberta Menafra,Anne Schreuder,Susan L Kloet,Titia K Sixma,Sylvie M Noordermeer

USP1/UAF1 targets polyubiquitinated PCNA with an exo-cleavage mechanism that can temporarily enrich for monoubiquitinated PCNA

USP1/UAF1 通过外切酶机制靶向多泛素化的 PCNA,该机制可暂时富集单泛素化的 PCNA。

Keijzer, Niels; Sakoltchik, Jan; Majumder, Kaustav; van Lil, Nina; El Oualid, Farid; Fish, Alexander; Sixma, Titia K

Variety in the USP deubiquitinase catalytic mechanism

USP 去泛素化酶催化机制的多样性

Niels Keijzer, Anu Priyanka, Yvette Stijf-Bultsma, Alexander Fish, Malte Gersch, Titia K Sixma

Unexpected moves: a conformational change in MutSα enables high-affinity DNA mismatch binding

出乎意料的举动:MutSα 的构象变化使其能够高亲和力地结合 DNA 错配。

Susanne R Bruekner,Wietske Pieters,Alexander Fish,A Manuel Liaci,Serge Scheffers,Emily Rayner,Daphne Kaldenbach,Lisa Drost,Marleen Dekker,Sandrine van Hees-Stuivenberg,Elly Delzenne-Goette,Charlotte de Konink,Hellen Houlleberghs,Hendrikus Jan Dubbink,Abeer AlSaegh,Niels de Wind,Friedrich Förster,Hein Te Riele,Titia K Sixma

Chaperoning of the histone octamer by the acidic domain of DNA repair factor APLF

DNA 修复因子 APLF 的酸性结构域对组蛋白八聚体进行陪伴

Ivan Corbeski, Xiaohu Guo, Bruna V Eckhardt, Domenico Fasci, Wouter Wiegant, Melissa A Graewert, Kees Vreeken, Hans Wienk, Dmitri I Svergun, Albert J R Heck, Haico van Attikum, Rolf Boelens, Titia K Sixma, Francesca Mattiroli, Hugo van Ingen

Insert L1 is a central hub for allosteric regulation of USP1 activity

插入 L1 是 USP1 活性变构调节的中心枢纽

Shreya Dharadhar, Willem J van Dijk, Serge Scheffers, Alexander Fish, Titia K Sixma

AI revolutions in biology: The joys and perils of AlphaFold

人工智能在生物学领域的革命:AlphaFold 的机遇与挑战

Perrakis, Anastassis; Sixma, Titia K

Proteomic analysis identifies novel binding partners of BAP1

蛋白质组学分析鉴定出BAP1的新型结合伙伴

Roy Baas, Fenna J van der Wal, Onno B Bleijerveld, Haico van Attikum, Titia K Sixma

Structural analysis of the LDL receptor-interacting FERM domain in the E3 ubiquitin ligase IDOL reveals an obscured substrate-binding site

E3 泛素连接酶 IDOL 中与 LDL 受体相互作用的 FERM 结构域的结构分析揭示了一个模糊的底物结合位点

Luca Martinelli, Athanassios Adamopoulos, Patrik Johansson, Paul T Wan, Jenny Gunnarsson, Hongwei Guo, Helen Boyd, Noam Zelcer, Titia K Sixma

The unstructured linker arms of MutL enable GATC site incision beyond roadblocks during initiation of DNA mismatch repair

MutL 的非结构化连接臂使 GATC 位点切口能够在 DNA 错配修复启动期间越过障碍物

Yannicka S N Mardenborough, Katerina Nitsenko, Charlie Laffeber, Camille Duboc, Enes Sahin, Audrey Quessada-Vial, Herrie H K Winterwerp, Titia K Sixma, Roland Kanaar, Peter Friedhoff, Terence R Strick, Joyce H G Lebbink