MNK Inhibition Sensitizes KRAS-Mutant Colorectal Cancer to mTORC1 Inhibition by Reducing eIF4E Phosphorylation and c-MYC Expression
MNK抑制通过降低eIF4E磷酸化和c-MYC表达,增强KRAS突变型结直肠癌对mTORC1抑制剂的敏感性。
期刊:Cancer Discovery
影响因子:29.7
doi:10.1158/2159-8290.CD-20-0652
John R P Knight ,Constantinos Alexandrou ,George L Skalka ,Nikola Vlahov ,Kathryn Pennel ,Leah Officer ,Ana Teodosio ,Georgios Kanellos ,David M Gay ,Sebastian May-Wilson ,Ewan M Smith ,Arafath K Najumudeen ,Kathryn Gilroy ,Rachel A Ridgway ,Dustin J Flanagan ,Rachael C L Smith ,Laura McDonald ,Craig MacKay ,Anne Cheasty ,Kerri McArthur ,Emma Stanway ,Joshua D Leach ,Rene Jackstadt ,Joseph A Waldron ,Andrew D Campbell ,Georgios Vlachogiannis ,Nicola Valeri ,Kevin M Haigis ,Nahum Sonenberg ,Christopher G Proud ,Neil P Jones ,Martin E Swarbrick ,Heather J McKinnon ,William J Faller ,John Le Quesne ,Joanne Edwards ,Anne E Willis ,Martin Bushell ,Owen J Sansom
ORC1
磷酸化
信号转导
RAS
肿瘤免疫
IF4E
mTOR
MYC
肠癌
肿瘤