日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Optimization of a Novel DEL Hit That Binds in the Cbl-b SH2 Domain and Blocks Substrate Binding

优化一种新型DEL先导化合物,该化合物能与Cbl-b SH2结构域结合并阻断底物结合

Liang, Jun; Lambrecht, Michael J; Arenzana, Teresita L; Aubert-Nicol, Samuel; Bao, Linda; Broccatelli, Fabio; Cai, Jianping; Eidenschenk, Celine; Everett, Christine; Garner, Thomas; Gruber, Felix; Haghshenas, Pouyan; Huestis, Malcolm P; Hsu, Peter L; Kou, Ponien; Jakalian, Araz; Larouche-Gauthier, Robin; Leclerc, Jean-Philippe; Leung, Dennis H; Martin, Aaron; Murray, Jeremy; Prangley, Madeleine; Rutz, Sascha; Kakiuchi-Kiyota, Satoko; Satz, Alexander Lee; Skelton, Nicholas J; Steffek, Micah; Stoffler, Daniel; Sudhamsu, Jawahar; Tan, Sophia; Wang, Jian; Wang, Shouliang; Wang, Qiuyue; Wendorff, Timothy J; Wichert, Moreno; Yadav, Arun; Yu, Christine; Wang, Xiaojing

Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

小分子配体与Ras蛋白的特定口袋结合,抑制SOS介导的核苷酸交换活性。

Maurer, Till; Garrenton, Lindsay S; Oh, Angela; Pitts, Keith; Anderson, Daniel J; Skelton, Nicholas J; Fauber, Benjamin P; Pan, Borlan; Malek, Shiva; Stokoe, David; Ludlam, Mary J C; Bowman, Krista K; Wu, Jiansheng; Giannetti, Anthony M; Starovasnik, Melissa A; Mellman, Ira; Jackson, Peter K; Rudolph, Joachim; Wang, Weiru; Fang, Guowei

Disruption of PH-kinase domain interactions leads to oncogenic activation of AKT in human cancers

PH激酶结构域相互作用的破坏会导致人类癌症中AKT的致癌激活。

Parikh, Chaitali; Janakiraman, Vasantharajan; Wu, Wen-I; Foo, Catherine K; Kljavin, Noelyn M; Chaudhuri, Subhra; Stawiski, Eric; Lee, Brian; Lin, Jie; Li, Hong; Lorenzo, Maria N; Yuan, Wenlin; Guillory, Joseph; Jackson, Marlena; Rondon, Jesus; Franke, Yvonne; Bowman, Krista K; Sagolla, Meredith; Stinson, Jeremy; Wu, Thomas D; Wu, Jiansheng; Stokoe, David; Stern, Howard M; Brandhuber, Barbara J; Lin, Kui; Skelton, Nicholas J; Seshagiri, Somasekar

Structural and functional analysis of the PDZ domains of human HtrA1 and HtrA3.

人类 HtrA1 和 HtrA3 的 PDZ 结构域的结构和功能分析

Runyon Steven T, Zhang Yingnan, Appleton Brent A, Sazinsky Stephen L, Wu Ping, Pan Borlan, Wiesmann Christian, Skelton Nicholas J, Sidhu Sachdev S