日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Molecular basis of 60 years of antigenic evolution of human influenza A(H3N2) virus neuraminidase

人类甲型流感病毒(H3N2)神经氨酸酶60年抗原演化的分子基础

Rosu, Miruna E; Westgeest, Kim B; de Graaf, Miranda; Hauser, Blake M; Tureli, Sina; James, Sarah; Sinartio, Felisita F; Bestebroer, Theo M; Lexmond, Pascal; Pronk, Mark R; van der Vliet, Stefan; Skepner, Eugene; Spronken, Monique I J; Mühlemann, Barbara; Richard, Mathilde; Jones, Terry C; Smith, Derek J; Herfst, Sander; Fouchier, Ron A M

Explainable Physicochemical Determinants of Protein-Ligand Binding via Non-Covalent Interactions

通过非共价相互作用解释蛋白质-配体结合的可解释的物理化学决定因素

Meng, Zhaohan; Bai, Zhen; Yuan, Ke; Cheah, Jaime H; Jiang, Wei; Skepner, Adam; Leahy, Kevin J; Ounis, Iadh; Oldham, William M; Meng, Zaiqiao; Xu, Hao; Loscalzo, Joseph

nELISA: a high-throughput, high-plex platform enables quantitative profiling of the inflammatory secretome

nELISA:一种高通量、高复数平台,可对炎症分泌组进行定量分析。

Dagher, Milad; Ongo, Grant; Robichaud, Nathaniel; Kong, Jinglin; Rho, Woojong; Teahulos, Ivan; Tavakoli, Arya; Bovaird, Samantha; Merjaneh, Shahem; Tan, Andrew; Edwardson, Kiran; Scheepers, Christelle; Ng, Andy; Hajjar, Andy; Sow, Baly; Vrouvides, Michael; Lee, Andy; DeCorwin-Martin, Philippe; Rasool, Shafqat; Huang, Jiamin; Erps, Timothy; Coffin, Spencer; Rashidi, Narges M; Han, Yu; Chandrasekaran, Srinivas Niranj; Miller, Lisa; Kost-Alimova, Maria; Skepner, Adam; Singh, Shantanu; Carpenter, Anne E; Munzar, Jeffrey D; Juncker, David

Identification of small molecule inhibitors of PPM1D using an integrated drug discovery platform.

利用综合药物发现平台鉴定PPM1D小分子抑制剂

Shaw Subrata, Jiang Wei, Rush Jason, Dumont Nancy, Kim John, Singh Ritu, Skepner Adam, Khodier Carol, Raffier Cerise, Murphy Zachary, Yan Ni, Schluter Cameron, Yu Xiao, Szuchnicki Mateusz, Sathappa Murugappan, Kahn Josephine, Sperling Adam S, Wagner Florence, McKinney David C, Gould Alexandra E, Garvie Colin W, Miller Peter G

nELISA: A high-throughput, high-plex platform enables quantitative profiling of the inflammatory secretome

nELISA:一种高通量、高复数平台,可对炎症分泌组进行定量分析。

Dagher, Milad; Ongo, Grant; Robichaud, Nathaniel; Kong, Jinglin; Rho, Woojong; Teahulos, Ivan; Tavakoli, Arya; Bovaird, Samantha; Merjaneh, Shahem; Tan, Andrew; Edwardson, Kiran; Scheepers, Christelle; Ng, Andy; Hajjar, Andy; Sow, Baly; Vrouvides, Michael; Lee, Andy; DeCorwin-Martin, Philippe; Rasool, Shafqat; Huang, Jiamin; Erps, Timothy; Coffin, Spencer; Han, Yu; Chandrasekaran, Srinivas Niranj; Miller, Lisa; Kost-Alimova, Maria; Skepner, Adam; Singh, Shantanu; Carpenter, Anne E; Munzar, Jeffrey; Juncker, David

Phenotypic screening converges on CDK9 inhibition as a therapeutic strategy in translocation renal cell carcinoma.

表型筛选结果表明,CDK9 抑制是易位性肾细胞癌的一种治疗策略

Thapa Dharma R, Deodhar Riva, Skepner Adam, Konda Prathyusha, Zhou Meng, Bluck Joseph, Pichlo Christian, Cui Yantong, Stocker Paige, Khanna Prateek, Li Jiao, Tsai Jonathan M, Leed Alison, Gould Sandy, Alimova Maria, Friedrich Dhana, Cheah Jaime H, Rupaimoole Rajesha, Guicherit Oivin, Viswanathan Srinivas R

Three million images and morphological profiles of cells treated with matched chemical and genetic perturbations

经过匹配的化学和遗传干扰处理的细胞的三百万张图像和形态学资料

Srinivas Niranj Chandrasekaran, Beth A Cimini, Amy Goodale, Lisa Miller, Maria Kost-Alimova, Nasim Jamali, John G Doench, Briana Fritchman, Adam Skepner, Michelle Melanson, Alexandr A Kalinin, John Arevalo, Marzieh Haghighi, Juan C Caicedo, Daniel Kuhn, Desiree Hernandez, James Berstler, Hamdah Shaf

Identification of Small Molecule Inhibitors of PPM1D Using a Novel Drug Discovery Platform

利用新型药物发现平台鉴定 PPM1D 小分子抑制剂

Wei Jiang, Subrata Shaw, Jason Rush, Nancy Dumont, John Kim, Ritu Singh, Adam Skepner, Carol Khodier, Cerise Raffier, Ni Yan, Cameron Schluter, Xiao Yu, Mateusz Szuchnicki, Murugappan Sathappa, Josephine Kahn, Adam S Sperling, David C McKinney, Alexandra E Gould, Colin W Garvie, Peter G Miller

Antigenic mapping of the hemagglutinin of the H9 subtype influenza A viruses using sera from Japanese quail (Coturnix c. japonica)

利用日本鹌鹑(Coturnix c. japonica)血清对H9亚型甲型流感病毒血凝素进行抗原定位

Carnaccini, Silvia; Cáceres, C Joaquín; Gay, L Claire; Ferreri, Lucas M; Skepner, Eugene; Burke, David F; Brown, Ian H; Geiger, Ginger; Obadan, Adebimpe; Rajao, Daniela S; Lewis, Nicola S; Perez, Daniel R

Molecular basis for substrate recruitment to the PRMT5 methylosome

PRMT5 甲基化酶体底物募集的分子基础

Kathleen M Mulvaney, Christa Blomquist, Nischal Acharya, Ruitong Li, Matthew J Ranaghan, Meghan O'Keefe, Diego J Rodriguez, Michael J Young, Devishi Kesar, Debjani Pal, Matthew Stokes, Alissa J Nelson, Sidharth S Jain, Annan Yang, Zachary Mullin-Bernstein, Josie Columbus, Fazli K Bozal, Adam Skepner