日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Library docking for Cannabinoid-2 Receptor ligands

大麻素-2受体配体的库对接

Rachman, Moira M; Iliopoulos-Tsoutsouvas, Christos; Sacco, Michael D; Xu, Xinyu; Wu, Cheng-Guo; Santos, Emma; Glenn, Isabella S; Paris, Lu; Cahill, Michelle K; Ganapathy, Suthakar; Tummino, Tia A; Moroz, Yurii S; Radchenko, Dmytro S; Okorie, Meri; Tawfik, Vivianne; Irwin, John J; Makriyannis, Alexandros; Skiniotis, Georgios; Shoichet, Brian K

MIC: A deep learning tool for assigning ions and waters in cryo-EM and crystal structures

MIC:一种用于在冷冻电镜和晶体结构中分配离子和水分子的深度学习工具

Shub, Laura; Liu, Wenjin; Skiniotis, Georgios; Keiser, Michael J; Robertson, Michael J

The adhesion GPCR ADGRL2 engages Gα13 to enable epidermal differentiation

黏附性 GPCR ADGRL2 与 Gα13 结合,促进表皮分化。

Yang, Xue; He, Feng; Lopez-Pajares, Vanessa; Porter, Douglas F; Garbett, Krassimira; Siprashvili, Zurab; Ducoli, Luca; Meyers, Robin M; Reynolds, David L; Lan Huong Bui, Duy; Hong, Audrey; Nguyen, Duy Thanh; Jing, Yuqing; Mondal, Smarajit; Ko, Lisa; Tao, Shiying; Singal, Bharti; Sando, Richard; Skiniotis, Georgios; Khavari, Paul A

A putative binding model of nitazene derivatives at the μ-opioid receptor

硝嗪衍生物与μ-阿片受体结合的假定模型

Clayton, Joseph; Shi, Lei; Robertson, Michael J; Skiniotis, Georgios; Michaelides, Michael; Stavitskaya, Lidiya; Shen, Jana

Non-Equilibrium Snapshots of Ligand Efficacy at the μ-Opioid Receptor

μ-阿片受体配体效力的非平衡快照

Robertson, Michael J; Papasergi-Scott, Makaía M; Peroto, Maria Claudia; Varga, Balazs R; Majumdar, Susruta; Skiniotis, Georgios

A Putative Binding Model of Nitazene Derivatives at the μ-Opioid Receptor

硝嗪衍生物与μ-阿片受体结合的假定模型

Clayton, Joseph; Shi, Lei; Robertson, Michael J; Skiniotis, Georgios; Michaelides, Michael; Stavitskaya, Lidiya; Shen, Jana

The Adhesion GPCR ADGRL2 engages Gα13 to Enable Epidermal Differentiation

粘附 GPCR ADGRL2 与 Gα13 结合,促进表皮分化

Yang, Xue; He, Feng; Porter, Douglas F; Garbett, Krassimira; Meyers, Robin M; Reynolds, David L; Bui, Duy Lan Huong; Hong, Audrey; Ducoli, Luca; Siprashvili, Zurab; Lopez-Pajares, Vanessa; Mondal, Smarajit; Ko, Lisa; Jing, Yuqing; Tao, Shiying; Singal, Bharti; Sando, Richard; Skiniotis, Georgios; Khavari, Paul A

Allosteric modulation and G-protein selectivity of the Ca(2+)-sensing receptor.

Ca(2+)敏感受体的变构调节和G蛋白选择性

He Feng, Wu Cheng-Guo, Gao Yang, Rahman Sabrina N, Zaoralová Magda, Papasergi-Scott Makaía M, Gu Ting-Jia, Robertson Michael J, Seven Alpay B, Li Lingjun, Mathiesen Jesper M, Skiniotis Georgios

AlphaFold2 structures guide prospective ligand discovery

AlphaFold2结构指导潜在配体的发现

Lyu, Jiankun; Kapolka, Nicholas; Gumpper, Ryan; Alon, Assaf; Wang, Liang; Jain, Manish K; Barros-Álvarez, Ximena; Sakamoto, Kensuke; Kim, Yoojoong; DiBerto, Jeffrey; Kim, Kuglae; Glenn, Isabella S; Tummino, Tia A; Huang, Sijie; Irwin, John J; Tarkhanova, Olga O; Moroz, Yurii; Skiniotis, Georgios; Kruse, Andrew C; Shoichet, Brian K; Roth, Bryan L

Large library docking identifies positive allosteric modulators of the calcium-sensing receptor.

大型化合物库对接鉴定出钙敏感受体的正向变构调节剂

Liu Fangyu, Wu Cheng-Guo, Tu Chia-Ling, Glenn Isabella, Meyerowitz Justin, Kaplan Anat Levit, Lyu Jiankun, Cheng Zhiqiang, Tarkhanova Olga O, Moroz Yurii S, Irwin John J, Chang Wenhan, Shoichet Brian K, Skiniotis Georgios