日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Utilizing Constrained Bicyclic Peptides for In Vitro Diagnostics.

利用受限双环肽进行体外诊断。

Shamsabadi André, Creamer Adam, Sadler Christy J, Abdelwahed Aida, Gaynor Katherine U, Demydchuk Yuliya, Ivanova-Berndt Gabriela, Van Rietschoten Katerine, Beswick Paul, Chen Liuhong, Arruda Bezerra Gustavo, Lulla Aleksei, Brear Paul, Hyvönen Marko, Skynner Michael J, Stevens Molly M

Conjugation to a transferrin receptor 1-binding Bicycle peptide enhances ASO and siRNA potency in skeletal and cardiac muscles

与转铁蛋白受体1结合的双环肽偶联可增强ASO和siRNA在骨骼肌和心肌中的效力。

Østergaard, Michael E; Carrer, Michele; Anderson, Brooke A; Afetian, Megan; Bakooshli, Mohsen A; Santos, Jinro A; Klein, Stephanie K; Capitanio, Juliana; Freestone, Graeme C; Tanowitz, Michael; Galindo-Murillo, Rodrigo; Gaus, Hans J; Dwyer, Chrissa A; Jackson, Michaela; Jafar-Nejad, Paymaan; Rigo, Frank; Seth, Punit P; Gaynor, Katherine U; Stanway, Steven J; Urbonas, Liudvikas; St Denis, Megan A; Pellegrino, Simone; Bezerra, Gustavo A; Rigby, Michael; Gowans, Ellen; Van Rietschoten, Katerine; Beswick, Paul; Chen, Liuhong; Skynner, Michael J; Swayze, Eric E

Discovery and chemical optimisation of a potent, Bi-cyclic antimicrobial inhibitor of Escherichia coli PBP3

发现并化学优化了一种强效的双环抗菌抑制剂,该抑制剂可抑制大肠杆菌 PBP3 的活性。

Rowland, Catherine E; Newman, Hector; Martin, Tazmin T; Dods, Rachel; Bournakas, Nikolaos; Wagstaff, James M; Lewis, Nick; Stanway, Steven J; Balmforth, Matthew; Kessler, Celia; van Rietschoten, Katerine; Bellini, Dom; Roper, David I; Lloyd, Adrian J; Dowson, Christopher G; Skynner, Michael J; Beswick, Paul; Dawson, Michael J

Investigating Penetration and Antimicrobial Activity of Vector-Bicycle Conjugates

研究载体-环状缀合物的渗透性和抗菌活性

Hadjicharalambous, Andreas; Newman, Hector; Lewis, Nick; Rowland, Catherine; Bournakas, Nikolaos; Stanway, Steven J; Dawson, Michael; Skynner, Michael J; Beswick, Paul

BT8009; A Nectin-4 Targeting Bicycle Toxin Conjugate for Treatment of Solid Tumors

BT8009;一种靶向Nectin-4的环状毒素偶联物,用于治疗实体瘤

Rigby, Michael; Bennett, Gavin; Chen, Liuhong; Mudd, Gemma E; Harrison, Helen; Beswick, Paul J; Van Rietschoten, Katerine; Watcham, Sophie M; Scott, Heather S; Brown, Amy N; Park, Peter U; Campbell, Carly; Haines, Eric; Lahdenranta, Johanna; Skynner, Michael J; Jeffrey, Phil; Keen, Nicholas; Lee, Kevin

Antimicrobial and Cell-Penetrating Peptides: Understanding Penetration for the Design of Novel Conjugate Antibiotics

抗菌肽和细胞穿透肽:了解穿透机制以设计新型偶联抗生素

Hadjicharalambous, Andreas; Bournakas, Nikolaos; Newman, Hector; Skynner, Michael J; Beswick, Paul

Nicotinic acetylcholine receptor expression and susceptibility to cholinergic immunomodulation in human monocytes of smoking individuals.

吸烟者单核细胞中尼古丁乙酰胆碱受体的表达及对胆碱能免疫调节的敏感性

van der Zanden Esmerij P, Hilbers Francisca W, Verseijden Caroline, van den Wijngaard Rene M, Skynner Mike, Lee Kevin, Ulloa Luis, Boeckxstaens Guy E, de Jonge Wouter J

Mutations in Grxcr1 are the basis for inner ear dysfunction in the pirouette mouse

Grxcr1基因突变是旋转小鼠内耳功能障碍的根本原因。

Odeh, Hana; Hunker, Kristina L; Belyantseva, Inna A; Azaiez, Hela; Avenarius, Matthew R; Zheng, Lili; Peters, Linda M; Gagnon, Leona H; Hagiwara, Nobuko; Skynner, Michael J; Brilliant, Murray H; Allen, Nicholas D; Riazuddin, Saima; Johnson, Kenneth R; Raphael, Yehoash; Najmabadi, Hossein; Friedman, Thomas B; Bartles, James R; Smith, Richard J H; Kohrman, David C

Selective alpha7 nicotinic acetylcholine receptor agonists worsen disease in experimental colitis

选择性α7尼古丁乙酰胆碱受体激动剂会加重实验性结肠炎的病情。

Snoek, Susanne A; Verstege, Marleen I; van der Zanden, Esmerij P; Deeks, Nigel; Bulmer, David C; Skynner, Michael; Lee, Kevin; Te Velde, Anje A; Boeckxstaens, Guy E; de Jonge, Wouter J

Disruption of ephrin signaling associates with disordered axophilic migration of the gonadotropin-releasing hormone neurons

Ephrin 信号传导中断与促性腺激素释放激素神经元的轴嗜性迁移紊乱有关

John A Gamble, Delicia K Karunadasa, Jean-Rémi Pape, Michael J Skynner, Martin G Todman, R John Bicknell, Jeremy P Allen, Allan E Herbison