日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Leveraging complementary multi-omics data integration methods for mechanistic insights in kidney diseases

利用互补的多组学数据整合方法深入了解肾脏疾病的机制

Alakwaa, Fadhl; Das, Vivek; Majumdar, Arindam; Nair, Viji; Fermin, Damian; Dey, Asim B; Slidel, Timothy; Reilly, Dermot F; Myshkin, Eugene; Duffin, Kevin L; Chen, Yu; Bitzer, Markus; Pennathur, Subramaniam; Brosius, Frank C; Kretzler, Matthias; Ju, Wenjun; Karihaloo, Anil; Eddy, Sean

Unbiased kidney-centric molecular categorization of chronic kidney disease as a step towards precision medicine

以肾脏为中心的无偏分子分型方法对慢性肾脏病进行分类,是迈向精准医疗的重要一步。

Reznichenko, Anna; Nair, Viji; Eddy, Sean; Fermin, Damian; Tomilo, Mark; Slidel, Timothy; Ju, Wenjun; Henry, Ian; Badal, Shawn S; Wesley, Johnna D; Liles, John T; Moosmang, Sven; Williams, Julie M; Quinn, Carol Moreno; Bitzer, Markus; Hodgin, Jeffrey B; Barisoni, Laura; Karihaloo, Anil; Breyer, Matthew D; Duffin, Kevin L; Patel, Uptal D; Magnone, Maria Chiara; Bhat, Ratan; Kretzler, Matthias

Inhibition of Interleukin-33 to Reduce Glomerular Endothelial Inflammation in Diabetic Kidney Disease

抑制白细胞介素-33可减轻糖尿病肾病中的肾小球内皮炎症

Alexis Hofherr ,Elena Liarte Marin ,Barbara Musial ,Asha Seth ,Tim Slidel ,James Conway ,David Baker ,Pernille B L Hansen ,Benjamin Challis ,Stefano Bartesaghi ,Maria Bhat ,Roberto Pecoits-Filho ,Xiao Tu ,Viknesh Selvarajah ,Kevin Woollard ,Hiddo J L Heerspink

Efficacy and pharmacodynamic effect of anti-CD73 and anti-PD-L1 monoclonal antibodies in combination with cytotoxic therapy: observations from mouse tumor models

抗 CD73 和抗 PD-L1 单克隆抗体联合细胞毒疗法的疗效和药效学作用:来自小鼠肿瘤模型的观察

Brajesh P Kaistha, Gozde Kar, Andreas Dannhorn, Amanda Watkins, Grace Opoku-Ansah, Kristina Ilieva, Stefanie Mullins, Judith Anderton, Elena Galvani, Fabien Garcon, Jean-Martin Lapointe, Lee Brown, James Hair, Tim Slidel, Nadia Luheshi, Kelli Ryan, Elizabeth Hardaker, Simon Dovedi, Rakesh Kumar, Rob

Small Gene Networks Delineate Immune Cell States and Characterize Immunotherapy Response in Melanoma

小型基因网络可界定免疫细胞状态并表征黑色素瘤的免疫治疗反应

Egan, Donagh; Kreileder, Martina; Nabhan, Myriam; Iglesias-Martinez, Luis F; Dovedi, Simon J; Valge-Archer, Viia; Grover, Amit; Wilkinson, Robert W; Slidel, Timothy; Bendtsen, Claus; Barrett, Ian P; Brennan, Donal J; Kolch, Walter; Zhernovkov, Vadim

Distinct mechanisms govern populations of myeloid-derived suppressor cells in chronic viral infection and cancer

慢性病毒感染和癌症中髓系来源抑制细胞群的调控机制各不相同。

Tcyganov, Evgenii N; Hanabuchi, Shino; Hashimoto, Ayumi; Campbell, David; Kar, Gozde; Slidel, Timothy Wf; Cayatte, Corinne; Landry, Aimee; Pilataxi, Fernanda; Hayes, Susana; Dougherty, Brian; Hicks, Kristin C; Mulgrew, Kathy; Tang, Chih-Hang Anthony; Hu, Chih-Chi Andrew; Guo, Wei; Grivennikov, Sergei; Ali, Mohammed-Alkhatim A; Beltra, Jean-Christophe; Wherry, E John; Nefedova, Yulia; Gabrilovich, Dmitry I

Novel non-terminal tumor sampling procedure using fine needle aspiration supports immuno-oncology biomarker discovery in preclinical mouse models

采用细针抽吸的新型非终末肿瘤取样程序支持临床前小鼠模型中的免疫肿瘤生物标志物发现

Suzanne Isabelle Sitnikova, Sophie Munnings-Tomes, Elena Galvani, Stacy Kentner, Kathy Mulgrew, Chris Rands, Judit España Agustí, Tianhui Zhang, Kristina M Ilieva, Guglielmo Rosignoli, Hormas Ghadially, Matthew J Robinson, Tim Slidel, Robert W Wilkinson, Simon J Dovedi

A Framework for Multi-Omic Prediction of Treatment Response to Biologic Therapy for Psoriasis

基于多组学的银屑病生物疗法疗效预测框架

Foulkes, Amy C; Watson, David S; Carr, Daniel F; Kenny, John G; Slidel, Timothy; Parslew, Richard; Pirmohamed, Munir; Anders, Simon; Reynolds, Nick J; Griffiths, Christopher E M; Warren, Richard B; Barnes, Michael R

Haplosaurus computes protein haplotypes for use in precision drug design

Haplosaurus 计算蛋白质单倍型用于精准药物设计

William Spooner, William McLaren, Timothy Slidel, Donna K Finch, Robin Butler, Jamie Campbell, Laura Eghobamien, David Rider, Christine Mione Kiefer, Matthew J Robinson, Colin Hardman, Fiona Cunningham, Tristan Vaughan, Paul Flicek, Catherine Chaillan Huntington

Staphylococcus aureus Alpha-Toxin Is Conserved among Diverse Hospital Respiratory Isolates Collected from a Global Surveillance Study and Is Neutralized by Monoclonal Antibody MEDI4893

金黄色葡萄球菌α毒素在从全球监测研究中收集的多种医院呼吸道分离株中均保守存在,并可被单克隆抗体MEDI4893中和。

Tabor, David E; Yu, Li; Mok, Hoyin; Tkaczyk, Christine; Sellman, Bret R; Wu, Yuling; Oganesyan, Vaheh; Slidel, Tim; Jafri, Hasan; McCarthy, Michael; Bradford, Patricia; Esser, Mark T