日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Long-acting GIPR agonist LY3537021 reduces body weight and fasting blood glucose in patients with T2D: Preclinical development and phase 1 randomized ascending dose studies

长效GIPR激动剂LY3537021可降低2型糖尿病患者的体重和空腹血糖：临床前开发和1期随机递增剂量研究

期刊:Molecular Metabolism
影响因子:6.6
doi:10.1016/j.molmet.2025.102298
Roell, William; Alsina-Fernandez, Jorge; Qu, Hongchang; Coskun, Tamer; Benson, Charles; Haupt, Axel; Kelly, Ronan P; O'Farrell, Libbey; Sloop, Kyle W; Steele, James P; Ficorilli, James; Regmi, Ajit; Rettiganti, Mallikarjuna; Urva, Shweta; Mather, Kieren J; Pratt, Edward
糖尿病
GIP
代谢
发表日期：2026
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Spatially diffuse cAMP signalling with oppositely biased GLP-1 receptor agonists in β-cells despite differences in receptor localisation

尽管受体定位存在差异，但在β细胞中，具有相反偏向性的GLP-1受体激动剂可引起空间弥散的cAMP信号传导。

期刊:Molecular Metabolism
影响因子:6.6
doi:10.1016/j.molmet.2025.102304
Chen, Shiqian; Lobato, Carolina B; Wong, Carissa; Manchanda, Yusman; Viloria, Katrina; Davies, Iona; Andersen, Daniel B; Ast, Julia; Sloop, Kyle W; Hodson, David J; Broichhagen, Johannes; Bloom, Steve; Holst, Jens J; Tan, Tricia; Tomas, Alejandra; Jones, Ben
信号转导
细胞生物学
GPCR/Calcium/cAMP
GLP-1
发表日期：2026
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GLP-1R biased cAMP agonism maintains glycemic control with reduced malaise and emesis in preclinical mammalian models

在临床前哺乳动物模型中，GLP-1R 偏向性 cAMP 激动剂作用可维持血糖控制，并减少不适和呕吐。

期刊:Diabetes Obesity & Metabolism
影响因子:5.7
doi:10.1111/dom.70427
Baumer-Harrison, Caitlin; Aldaghma, Danya; White, Alex D; Applebey, Sarah V; Pataro, Allison M; Mohiby, Allaha Z; Alonso, Brandon; Xiao, Allison G; O'Farrell, Libbey S; Qian, Yuewei; Coskun, Tamer; Coghlan, Matthew P; Willard, Francis S; Ai, Minrong; Sloop, Kyle W; Doyle, Robert P; Borner, Tito; De Jonghe, Bart C; Hayes, Matthew R
GPCR/Calcium/cAMP
GLP-1
发表日期：2026
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Impact of Evoked Compound Action Potential (ECAP)-Controlled Closed-Loop Spinal Cord Stimulation in Refractory Lumbar Radiculopathy: A Case Report

诱发复合动作电位（ECAP）控制的闭环脊髓刺激治疗难治性腰椎神经根病：病例报告

期刊:Cureus Journal of Medical Science
影响因子:1.3
doi:10.7759/cureus.102799
Soin, Aviraj; Kassis, Sarah; Witte, Richard J; Sloop, Ben; Brittain, Cameron
神经科学
发表日期：2026
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Publisher Correction: GIPR agonism and antagonism decrease body weight and food intake via different mechanisms in male mice

出版商更正：GIPR激动剂和拮抗剂通过不同的机制降低雄性小鼠的体重和食物摄入量。

期刊:Nature Metabolism
影响因子:20.8
doi:10.1038/s42255-025-01308-8
Gutgesell, Robert M; Khalil, Ahmed; Liskiewicz, Arkadiusz; Maity-Kumar, Gandhari; Novikoff, Aaron; Grandl, Gerald; Liskiewicz, Daniela; Coupland, Callum; Karaoglu, Ezgi; Akindehin, Seun; Castelino, Russell; Curion, Fabiola; Liu, Xue; Garcia-Caceres, Cristina; Cebrian-Serrano, Alberto; Douros, Jonathan D; Knerr, Patrick J; Finan, Brian; DiMarchi, Richard D; Sloop, Kyle W; Samms, Ricardo J; Theis, Fabian J; Tschöp, Matthias H; Müller, Timo D
GIP
发表日期：2025
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GIPR agonism and antagonism decrease body weight and food intake via different mechanisms in male mice.

GIPR激动剂和拮抗剂通过不同的机制降低雄性小鼠的体重和食物摄入量

期刊:Nature Metabolism
影响因子:20.8
doi:10.1038/s42255-025-01294-x
Gutgesell Robert M, Khalil Ahmed, Liskiewicz Arkadiusz, Maity-Kumar Gandhari, Novikoff Aaron, Grandl Gerald, Liskiewicz Daniela, Coupland Callum, Karaoglu Ezgi, Akindehin Seun, Castelino Russell, Curion Fabiola, Liu Xue, Garcia-Caceres Cristina, Cebrian-Serrano Alberto, Douros Jonathan D, Knerr Patrick J, Finan Brian, DiMarchi Richard D, Sloop Kyle W, Samms Ricardo J, Theis Fabian J, Tschöp Matthias H, Müller Timo D
GIP
发表日期：2025
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β Cell Gαs signaling is critical for physiological and pharmacological enhancement of insulin secretion

β细胞Gαs信号传导对于生理和药理学上增强胰岛素分泌至关重要。

期刊:Journal of Clinical Investigation
影响因子:13.6
doi:10.1172/JCI183741
Capozzi, Megan E; Bouslov, David; Sargsyan, Ashot; Chan, Michelle Y; Chen, Alex; Gray, Sarah M; Viloria, Katrina; Bareja, Akshay; Douros, Jonathan D; Lewandowski, Sophie L; Tong, Jason Cl; Hasib, Annie; Cuozzo, Federica; Ross, Elizabeth C; Foster, Matthew W; Weinstein, Lee S; Hussain, Mehboob A; Merrins, Matthew J; Willard, Francis S; Huising, Mark O; Sloop, Kyle W; Hodson, David J; D'Alessio, David A; Campbell, Jonathan E
信号转导
细胞生物学
免疫/内分泌
发表日期：2025
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α cells use both PC1/3 and PC2 to process proglucagon peptides and control insulin secretion

α细胞利用PC1/3和PC2来加工胰高血糖素原肽并控制胰岛素分泌。

期刊:Science Advances
影响因子:12.5
doi:10.1126/sciadv.ady8048
Cui, Canqi; Leander, Danielle C; Gray, Sarah M; El, Kimberley; Chen, Alex; Grimsrud, Paul A; Becker, Jessica O; Taylor, Austin; Zhang, Guo-Fang; Sloop, Kyle W; Verchere, C Bruce; Hoofnagle, Andrew N; D'Alessio, David A; Campbell, Jonathan E
细胞生物学
免疫/内分泌
发表日期：2025
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A Contemporary Rationale for Agonism of the GIP Receptor in the Treatment of Obesity

激动GIP受体治疗肥胖症的当代理论依据

期刊:Diabetes
影响因子:7.5
doi:10.2337/dbi24-0026
Samms, Ricardo J; Sloop, Kyle W
信号转导
肥胖
GIP
代谢
发表日期：2025
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Communicating with Stakeholders to Identify High-Impact Research Directions for Non-Targeted Analysis

与利益相关者沟通，确定非目标分析的高影响力研究方向

期刊:Analytical Chemistry
影响因子:6.7
doi:10.1021/acs.analchem.4c04801
Nason, Sara L; McCord, James; Feng, Yong-Lai; Sobus, Jon R; Fisher, Christine M; Marfil-Vega, Ruth; Phillips, Allison L; Johnson, Gregory; Sloop, John; Bayen, Stéphane; Mutlu, Esra; Batt, Angela L; Nahan, Keaton
发表日期：2025
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