Smaill Jeff B相关文献与解析，生知库 | 链接生命科学的每一步

日期影响因子

Discovery of 5-imidazole-3-methylbenz[d]isoxazole derivatives as potent and selective CBP/p300 bromodomain inhibitors for the treatment of acute myeloid leukemia.

发现 5-咪唑-3-甲基苯并[d]异恶唑衍生物是治疗急性髓系白血病的强效选择性 CBP/p300 溴结构域抑制剂

期刊:Acta Pharmacologica Sinica

影响因子:8.4

doi:10.1038/s41401-025-01478-x

Hu Jian-Kang, Tang Xin, Luo Guo-Long, Zhang Cheng, Wu Tian-Bang, Wang Chao, Shen Hui, Zhao Xiao-Fan, Wu Xi-Shan, Smaill Jeff B, Xu Yong, Zhang Yan, Xiang Qiu-Ping

发表日期：2025

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The third generation AKR1C3-activated prodrug, ACHM-025, eradicates disease in preclinical models of aggressive T-cell acute lymphoblastic leukemia.

第三代 AKR1C3 激活的前药 ACHM-025 可根除侵袭性 T 细胞急性淋巴细胞白血病的临床前模型中的疾病

期刊:Blood Cancer Journal

影响因子:11.6

doi:10.1038/s41408-024-01180-x

Toscan Cara E, McCalmont Hannah, Ashoorzadeh Amir, Lin Xiaojing, Fu Zhe, Doculara Louise, Kosasih Hansen J, Cadiz Roxanne, Zhou Anthony, Williams Sarah, Evans Kathryn, Khalili Faezeh, Cai Ruilin, Yeats Kristy L, Gifford Andrew J, Pickford Russell, Mayoh Chelsea, Xie Jinhan, Henderson Michelle J, Trahair Toby N, Patterson Adam V, Smaill Jeff B, de Bock Charles E, Lock Richard B

细胞生物学

发表日期：2024

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Structural Evaluation of a Nitroreductase Engineered for Improved Activation of the 5-Nitroimidazole PET Probe SN33623

对一种经工程改造以提高5-硝基咪唑PET探针SN33623活化能力的硝基还原酶进行结构评估

期刊:International Journal of Molecular Sciences

影响因子:4.9

doi:10.3390/ijms25126593

Sharrock, Abigail V; Mumm, Jeff S; Williams, Elsie M; Čėnas, Narimantas; Smaill, Jeff B; Patterson, Adam V; Ackerley, David F; Bagdžiūnas, Gintautas; Arcus, Vickery L

发表日期：2024

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Design and Biological Evaluation of Piperazine-Bearing Nitrobenzamide Hypoxia/GDEPT Prodrugs: The Discovery of CP-506

哌嗪基硝基苯甲酰胺缺氧/GDEPT前药的设计与生物学评价：CP-506的发现

期刊:ACS Medicinal Chemistry Letters

doi:10.1021/acsmedchemlett.3c00321

Ashoorzadeh, Amir; Mowday, Alexandra M; Abbattista, Maria R; Guise, Christopher P; Bull, Matthew R; Silva, Shevan; Patterson, Adam V; Smaill, Jeff B

发表日期：2023

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Interrogation of the Structure-Activity Relationship of a Lipophilic Nitroaromatic Prodrug Series Designed for Cancer Gene Therapy Applications

对用于癌症基因治疗的亲脂性硝基芳香族前药系列进行构效关系研究

期刊:Pharmaceuticals

影响因子:4.8

doi:10.3390/ph15020185

Ashoorzadeh, Amir; Mowday, Alexandra M; Guise, Christopher P; Silva, Shevan; Bull, Matthew R; Abbattista, Maria R; Copp, Janine N; Williams, Elsie M; Ackerley, David F; Patterson, Adam V; Smaill, Jeff B

发表日期：2022

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Tumour Hypoxia-Mediated Immunosuppression: Mechanisms and Therapeutic Approaches to Improve Cancer Immunotherapy

肿瘤乏氧介导的免疫抑制：改善癌症免疫治疗的机制和治疗方法

影响因子:5.2

doi:10.3390/cells10051006

Fu, Zhe; Mowday, Alexandra M; Smaill, Jeff B; Hermans, Ian F; Patterson, Adam V

免疫/内分泌

发表日期：2021

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Restoring Tumour Selectivity of the Bioreductive Prodrug PR-104 by Developing an Analogue Resistant to Aerobic Metabolism by Human Aldo-Keto Reductase 1C3

通过开发一种对人醛酮还原酶1C3有氧代谢具有抗性的类似物，恢复生物还原前药PR-104的肿瘤选择性

期刊:Pharmaceuticals

影响因子:4.8

doi:10.3390/ph14121231

Abbattista, Maria R; Ashoorzadeh, Amir; Guise, Christopher P; Mowday, Alexandra M; Mittra, Rituparna; Silva, Shevan; Hicks, Kevin O; Bull, Matthew R; Jackson-Patel, Victoria; Lin, Xiaojing; Prosser, Gareth A; Lambie, Neil K; Dachs, Gabi U; Ackerley, David F; Smaill, Jeff B; Patterson, Adam V

发表日期：2021

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Design, Synthesis and In-Vitro Biological Evaluation of Antofine and Tylophorine Prodrugs as Hypoxia-Targeted Anticancer Agents

安托芬和泰洛福林前药作为缺氧靶向抗癌药物的设计、合成及体外生物学评价

期刊:Molecules

影响因子:4.6

doi:10.3390/molecules26113327

Omran, Ziad; Guise, Chris P; Chen, Linwei; Rauch, Cyril; Abdalla, Ashraf N; Abdullah, Omeima; Sindi, Ikhlas A; Fischer, Peter M; Smaill, Jeff B; Patterson, Adam V; Liu, Yuxiu; Wang, Qingmin

发表日期：2021

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Subcellular Location of Tirapazamine Reduction Dramatically Affects Aerobic but Not Anoxic Cytotoxicity

替拉帕明还原的亚细胞定位显著影响有氧细胞毒性，但不影响缺氧细胞毒性

期刊:Molecules

影响因子:4.6

doi:10.3390/molecules25214888

Guise, Chris P; Abbattista, Maria R; Anderson, Robert F; Li, Dan; Taghipouran, Rana; Tsai, Angela; Lee, Su Jung; Smaill, Jeff B; Denny, William A; Hay, Michael P; Wilson, William R; Hicks, Kevin O; Patterson, Adam V

细胞生物学

发表日期：2020

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Advancing Clostridia to Clinical Trial: Past Lessons and Recent Progress

推进梭菌临床试验：过去的经验教训和最新进展

影响因子:4.4

doi:10.3390/cancers8070063

Mowday, Alexandra M; Guise, Christopher P; Ackerley, David F; Minton, Nigel P; Lambin, Philippe; Dubois, Ludwig J; Theys, Jan; Smaill, Jeff B; Patterson, Adam V

发表日期：2016

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