日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Plasmodium falciparum African PfCRT Mutant Isoforms Conducive to Piperaquine Resistance Are Infrequent and Impart a Major Fitness Cost

恶性疟原虫非洲型PfCRT突变异构体虽然罕见,但会导致哌喹耐药性,且会造成严重的适应性损失。

Hagenah, Laura M; Yeo, Tomas; Schindler, Kyra A; Jeon, Jin H; Bloxham, Talia S; Small-Saunders, Jennifer L; Mok, Sachel; Fidock, David A

Effects of recombination on multi-drug resistance evolution in Plasmodium falciparum malaria

重组对恶性疟原虫疟疾多重耐药性进化的影响

Tran, Kien Trung; Nguyen, Tran Dang; Weissman, Daniel B; Li, Eric Zhewen; Mok, Sachel; Small-Saunders, Jennifer L; Bousema, Teun; Zupko, Robert J; Tran, Thu Nguyen-Anh; Boni, Maciej F

Systematic in vitro evolution in Plasmodium falciparum reveals key determinants of drug resistance.

恶性疟原虫体外系统进化揭示了耐药性的关键决定因素

Luth Madeline R, Godinez-Macias Karla P, Chen Daisy, Okombo John, Thathy Vandana, Cheng Xiu, Daggupati Sindhu, Davies Heledd, Dhingra Satish K, Economy Jan M, Edgar Rebecca C S, Gomez-Lorenzo Maria G, Istvan Eva S, Jado Juan Carlos, LaMonte Gregory M, Melillo Bruno, Mok Sachel, Narwal Sunil K, Ndiaye Tolla, Ottilie Sabine, Palomo Diaz Sara, Park Heekuk, Peña Stella, Rocamora Frances, Sakata-Kato Tomoyo, Small-Saunders Jennifer L, Summers Robert L, Tumwebaze Patrick K, Vanaerschot Manu, Xia Guoqin, Yeo Tomas, You Ashley, Gamo Francisco-Javier, Goldberg Daniel E, Lee Marcus C S, McNamara Case W, Ndiaye Daouda, Rosenthal Philip J, Schreiber Stuart L, Serra Gloria, De Siqueira-Neto Jair Lage, Skinner-Adams Tina S, Uhlemann Anne-Catrin, Kato Nobutaka, Lukens Amanda K, Wirth Dyann F, Fidock David A, Winzeler Elizabeth A

Inhibitors of malaria parasite cyclic nucleotide phosphodiesterases block asexual blood-stage development and mosquito transmission.

疟原虫环核苷酸磷酸二酯酶抑制剂可阻断无性血液期发育和蚊子传播

Gomez-Gonzalez Paula-Josefina, Gupta Antima, Drought Laura G, Patel Avnish, Okombo John, van der Watt Mariëtte, Walker-Gray Ryan, Schindler Kyra A, Burkhard Anna Y, Yeo Tomas, Narwal Sunil K, Bloxham Talia S, Flueck Christian, Walker Eloise M, Rey Joshua A, Fairhurst Kate J, Reader Janette, Park Heekuk, Pollard Harry G, Stewart Lindsay B, Brandner-Garrod Luke, Kristan Mojca, Sterk Geert-Jan, van Nuland Youri M, Manko Emilia, van Schalkwyk Donelly A, Zheng Yang, Leurs Rob, Dechering Koen J, Aguiar Anna Caroline C, Guido Rafael V C, Pereira Dhelio B, Tumwebaze Patrick K, Nosbya Samuel L, Rosenthal Philip J, Cooper Roland A, Palmer Mike, Parkinson Tanya, Burrows Jeremy N, Uhlemann Anne-Catrin, Birkholtz Lyn-Marié, Small-Saunders Jennifer L, Duffy James, Fidock David A, Brown Alan, Gardner Mark, Baker David A

Additional PfCRT mutations driven by selective pressure for improved fitness can result in the loss of piperaquine resistance and altered Plasmodium falciparum physiology

在提高适应性的选择压力下,额外的 PfCRT 突变会导致哌喹耐药性的丧失和恶性疟原虫生理的改变。

Hagenah, Laura M; Dhingra, Satish K; Small-Saunders, Jennifer L; Qahash, Tarrick; Willems, Andreas; Schindler, Kyra A; Rangel, Gabriel W; Gil-Iturbe, Eva; Kim, Jonathan; Akhundova, Emiliya; Yeo, Tomas; Okombo, John; Mancia, Filippo; Quick, Matthias; Roepe, Paul D; Llinás, Manuel; Fidock, David A

Evidence for the early emergence of piperaquine-resistant Plasmodium falciparum malaria and modeling strategies to mitigate resistance

早期出现哌喹耐药性恶性疟原虫的证据及缓解耐药性的建模策略

Small-Saunders, Jennifer L; Hagenah, Laura M; Wicht, Kathryn J; Dhingra, Satish K; Deni, Ioanna; Kim, Jonathan; Vendome, Jeremie; Gil-Iturbe, Eva; Roepe, Paul D; Mehta, Monica; Mancia, Filippo; Quick, Matthias; Eppstein, Margaret J; Fidock, David A

Turning the tide: targeting PfCRT to combat drug-resistant P. falciparum?

扭转乾坤:靶向 PfCRT 以对抗耐药性恶性疟原虫?

Small-Saunders, Jennifer L; Hagenah, Laura M; Fidock, David A

Plasmodium falciparum resistance to piperaquine driven by PfCRT

由 PfCRT 驱动的恶性疟原虫对哌喹的耐药性

Dhingra, Satish K; Small-Saunders, Jennifer L; Ménard, Didier; Fidock, David A

Global Spread of Mutant PfCRT and Its Pleiotropic Impact on Plasmodium falciparum Multidrug Resistance and Fitness

突变型PfCRT的全球传播及其对恶性疟原虫多药耐药性和适应性的多效性影响

Dhingra, Satish K; Gabryszewski, Stanislaw J; Small-Saunders, Jennifer L; Yeo, Tomas; Henrich, Philipp P; Mok, Sachel; Fidock, David A

Generation of Transmission-Competent Human Malaria Parasites with Chromosomally-Integrated Fluorescent Reporters

利用染色体整合荧光报告基因构建具有传播能力的人类疟原虫

McLean, Kyle Jarrod; Straimer, Judith; Hopp, Christine S; Vega-Rodriguez, Joel; Small-Saunders, Jennifer L; Kanatani, Sachie; Tripathi, Abhai; Mlambo, Godfree; Dumoulin, Peter C; Harris, Chantal T; Tong, Xinran; Shears, Melanie J; Ankarklev, Johan; Kafsack, Björn F C; Fidock, David A; Sinnis, Photini