日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Boosting SIV-specific CD8+ T cell responses prior to ART interruption extends time to SIVmac239 rebound.

在 ART 中断之前增强 SIV 特异性 CD8+ T 细胞反应可延长 SIVmac239 反弹的时间。

Omange Were R, Varco-Merth Benjamin D, Fadeyi Omo, Marenco Alejandra, Takata Hiroshi, Duell Derick M, Goodwin William D, Armitage Paula, Fennessey Christine M, Kose Emek, Immonen Taina T, Kosmider Ewelina, Bosche William J, Fast Randy, Homick Chris, Oswald Kelli, Shoemaker Rebecca, Bochart Rachele, MacAllister Rhonda, Labriola Caralyn S, Smedley Jeremy V, Axthelm Michael K, Edlefsen Paul T, Keele Brandon F, Lifson Jeffrey D, Gergen Janina, Petsch Benjamin, Rauch Susanne, Picker Louis J, Okoye Afam A

Liver-specific transgenic expression of human NTCP in rhesus macaques confers HBV susceptibility on primary hepatocytes.

在恒河猴肝脏中特异性转基因表达人类NTCP可使原代肝细胞对HBV产生易感性

Rust Lauren N, Wettengel Jochen M, Biswas Sreya, Ryu Junghyun, Piekarski Nadine, Yusova Sofiya, Lutz Savannah S, Naldiga Spandana, Hinrichs Brayden J, Sullivan Michelle N, Lo Jamie O, Protzer Ulrike, Smedley Jeremy V, Sacha Jonah B, Hanna Carol B, Bimber Benjamin N, Hennebold Jon D, Burwitz Benjamin J

Liver biopsies obtained throughout SIV infection reveal evolving interferon stimulated protein expression within distinct monocyte/macrophage subsets

在SIV感染过程中获得的肝脏活检显示,不同单核细胞/巨噬细胞亚群中干扰素刺激蛋白的表达不断演变。

Derby, Nina; Johnson, Brooke I; Biswas, Sreya; Fischer, Miranda; Fancher, Katherine A; Luevano-Santos, Cristina; Yusova, Sofiya; Meyer, Kimberly A; Abraham, Yohannes M; Lutz, Savannah S; Fisher, Cole; Pacheco, Maria Cristina; Smedley, Jeremy V; Burwitz, Benjamin J; Sodora, Donald L

SIV Infection Is Associated with Transient Acute-Phase Steatosis in Hepatocytes In Vivo

SIV感染与体内肝细胞短暂性急性期脂肪变性相关

Derby, Nina; Biswas, Sreya; Yusova, Sofiya; Luevano-Santos, Cristina; Pacheco, Maria Cristina; Meyer, Kimberly A; Johnson, Brooke I; Fischer, Miranda; Fancher, Katherine A; Fisher, Cole; Abraham, Yohannes M; McMahon, Conor J; Lutz, Savannah S; Smedley, Jeremy V; Burwitz, Benjamin J; Sodora, Donald L

Safety (toxicity), pharmacokinetics, immunogenicity, and impact on elements of the normal immune system of recombinant human IL-15 in rhesus macaques.

重组人IL-15在恒河猴中的安全性(毒性)、药代动力学、免疫原性以及对正常免疫系统成分的影响

Waldmann Thomas A, Lugli Enrico, Roederer Mario, Perera Liyanage P, Smedley Jeremy V, Macallister Rhonda P, Goldman Carolyn K, Bryant Bonita R, Decker Jean M, Fleisher Thomas A, Lane H Clifford, Sneller Michael C, Kurlander Roger J, Kleiner David E, Pletcher John M, Figg William D, Yovandich Jason L, Creekmore Stephen P

Smallpox vaccine with integrated IL-15 demonstrates enhanced in vivo viral clearance in immunodeficient mice and confers long term protection against a lethal monkeypox challenge in cynomolgus monkeys.

含有整合 IL-15 的天花疫苗在免疫缺陷小鼠体内表现出增强的病毒清除能力,并能为食蟹猴提供针对致命性猴痘攻击的长期保护

Zielinski Rafal J, Smedley Jeremy V, Perera Pin-Yu, Silvera Peter M, Waldmann Thomas A, Capala Jacek, Perera Liyanage P