日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery and development of potent and selective dual NUAK/MARK inhibitors as Hippo pathway modulators for the treatment of cancer

发现和开发高效且选择性的双重NUAK/MARK抑制剂,作为Hippo通路调节剂用于癌症治疗

Smil, David; Liu, Yong; Xin, Tao; Kiyota, Taira; Aman, Ahmed; Grouleff, Julie; Hoffer, Laurent; Joshi, Dhananjay C; Inanlou, Mohammad R; Song, Siyuan; Mao, Daniel Y L; Ogunjimi, Abiodun A; Pau, Victor; Chini, Fiona D; Kurinov, Igor; Zhang, Ying; Nguyen, Anh Thu; Wrana, Jeffrey L; Sicheri, Frank; Attisano, Liliana; Uehling, David; Al-Awar, Rima; Isaac, Methvin B

Discovery of Two Highly Selective Structurally Orthogonal Chemical Probes for Activin Receptor-like Kinases 1 and 2

发现两种针对激活素受体样激酶 1 和 2 的高选择性结构正交化学探针

Václav Němec, Marek Remeš, Petr Beňovský, Michael C Böck, Eliška Šranková, Jong Fu Wong, Julien Cros, Eleanor Williams, Lap Hang Tse, David Smil, Deeba Ensan, Methvin B Isaac, Rima Al-Awar, Regina Gomolková, Vlad-Constantin Ursachi, Bohumil Fafílek, Zuzana Kahounová, Ráchel Víchová, Ondřej Vacek, Be

Discovery of Conformationally Constrained ALK2 Inhibitors

构象受限的ALK2抑制剂的发现

González-Álvarez, Héctor; Ensan, Deeba; Xin, Tao; Wong, Jong Fu; Zepeda-Velázquez, Carlos A; Cros, Julien; Sweeney, Melissa N; Hoffer, Laurent; Kiyota, Taira; Wilson, Brian J; Aman, Ahmed; Roberts, Owen; Isaac, Methvin B; Bullock, Alex N; Smil, David; Al-Awar, Rima

A non-traditional crystal-based compound screening method targeting the ATP binding site of Plasmodium falciparum GRP78 for identification of novel nucleoside analogues

一种针对恶性疟原虫 GRP78 的 ATP 结合位点的非传统基于晶体的化合物筛选方法,用于鉴定新型核苷类似物

Alexander Mrozek, Tetyana Antoshchenko, Yun Chen, Carlos Zepeda-Velázquez, David Smil, Nirbhay Kumar, Hua Lu, Hee-Won Park

Leveraging Open Science Drug Development for PET: Preliminary Neuroimaging of (11)C-Labeled ALK2 Inhibitors

利用开放科学进行PET药物开发:(11)C标记的ALK2抑制剂的初步神经影像学研究

Murrell, Emily; Tong, Junchao; Smil, David; Kiyota, Taira; Aman, Ahmed M; Isaac, Methvin B; Watson, Iain D G; Vasdev, Neil

Probing the SAM Binding Site of SARS-CoV-2 Nsp14 In Vitro Using SAM Competitive Inhibitors Guides Developing Selective Bisubstrate Inhibitors

使用 SAM 竞争性抑制剂体外探测 SARS-CoV-2 Nsp14 的 SAM 结合位点,指导开发选择性双底物抑制剂

Kanchan Devkota, Matthieu Schapira, Sumera Perveen, Aliakbar Khalili Yazdi, Fengling Li, Irene Chau, Pegah Ghiabi, Taraneh Hajian, Peter Loppnau, Albina Bolotokova, Karla J F Satchell, Ke Wang, Deyao Li, Jing Liu, David Smil, Minkui Luo, Jian Jin, Paul V Fish, Peter J Brown, Masoud Vedadi

Targeting ALK2: An Open Science Approach to Developing Therapeutics for the Treatment of Diffuse Intrinsic Pontine Glioma

靶向ALK2:采用开放科学方法开发治疗弥漫性内生性脑桥胶质瘤的疗法

Ensan, Deeba; Smil, David; Zepeda-Velázquez, Carlos A; Panagopoulos, Dimitrios; Wong, Jong Fu; Williams, Eleanor P; Adamson, Roslin; Bullock, Alex N; Kiyota, Taira; Aman, Ahmed; Roberts, Owen G; Edwards, Aled M; O'Meara, Jeff A; Isaac, Methvin B; Al-Awar, Rima

Leveraging an Open Science Drug Discovery Model to Develop CNS-Penetrant ALK2 Inhibitors for the Treatment of Diffuse Intrinsic Pontine Glioma

利用开放科学药物发现模型开发中枢神经系统渗透性 ALK2 抑制剂,用于治疗弥漫性内在性脑桥胶质瘤

David Smil, Jong Fu Wong, Eleanor P Williams, Roslin J Adamson, Alison Howarth, David A McLeod, Ahmed Mamai, Soyoung Kim, Brian J Wilson, Taira Kiyota, Ahmed Aman, Julie Owen, Gennady Poda, Kurumi Y Horiuchi, Ekaterina Kuznetsova, Haiching Ma, J Nicole Hamblin, Sue Cramp, Owen G Roberts, Aled M Edwa

A chemical biology toolbox to study protein methyltransferases and epigenetic signaling

研究蛋白质甲基转移酶和表观遗传信号传导的化学生物学工具箱

Sebastian Scheer, Suzanne Ackloo, Tiago S Medina, Matthieu Schapira, Fengling Li, Jennifer A Ward, Andrew M Lewis, Jeffrey P Northrop, Paul L Richardson, H Ümit Kaniskan, Yudao Shen, Jing Liu, David Smil, David McLeod, Carlos A Zepeda-Velazquez, Minkui Luo, Jian Jin, Dalia Barsyte-Lovejoy, Kilian V

Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3).

发现蛋白质精氨酸甲基转移酶 3 (PRMT3) 的强效选择性变构抑制剂

Kaniskan H Ümit, Eram Mohammad S, Zhao Kehao, Szewczyk Magdalena M, Yang Xiaobao, Schmidt Keith, Luo Xiao, Xiao Sean, Dai Miao, He Feng, Zang Irene, Lin Ying, Li Fengling, Dobrovetsky Elena, Smil David, Min Sun-Joon, Lin-Jones Jennifer, Schapira Matthieu, Atadja Peter, Li En, Barsyte-Lovejoy Dalia, Arrowsmith Cheryl H, Brown Peter J, Liu Feng, Yu Zhengtian, Vedadi Masoud, Jin Jian