日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Atypical GPCR Activation Resolved by Nanobody Engineering.

纳米抗体工程解决非典型GPCR激活问题。

Schlimgen Roman R, Jenjak Shawn E, De La Sancha Alexa, Darcis Joy, Billesbølle Christian B, Olson Linda J, Peterson Francis C, Smit Martine J, Manglik Aashish, Szpakowska Martyna, Chevigne Andy, Volkman Brian F

Constitutive activity of an atypical chemokine receptor revealed by inverse agonistic nanobodies

反向激动性纳米抗体揭示非典型趋化因子受体的组成型活性

Perez Almeria, Claudia V; Otun, Omolade; Schlimgen, Roman; Lamme, Thomas D; Di Niro, Lotte; Crudden, Caitrin; Bebelman, Jan Paul; Youssef, Noureldine; Musli, Lejla; Jenjak, Shawn; Bobkov, Vladimir; Drube, Julia; Hoffmann, Carsten; Volkman, Brian F; Granier, Sébastien; Bechara, Cherine; Siderius, Marco; Heukers, Raimond; Schafer, Christopher T; Smit, Martine J

Disruption of constitutive CXCR4 oligomers impairs oncogenic properties in lymphoid neoplasms.

CXCR4 寡聚体的组成破坏会损害淋巴瘤的致癌特性

Mobach Simon, Bergkamp Nick D, Ma Ziliang, Haselager Marco V, Anbuhl Stephanie M, Jurriens Daphne, van den Bor Jelle, Wang Ziming, Crudden Caitrin, Roos Jamie L, Perez Almeria Claudia V, Boergonje Rick A, Lohse Martin J, Bosma Reggie, Eldering Eric, Siderius Marco, Wu Wei, Spaargaren Marcel, Tonino Sanne H, Kater Arnon P, Smit Martine J, Heukers Raimond

Presentation of CXCL12γ by heparan sulfate proteoglycans activates CXCR4 without desensitization in normal and malignant B cells.

硫酸乙酰肝素蛋白聚糖呈递 CXCL12α 可激活正常和恶性 B 细胞中的 CXCR4,而不会发生脱敏

Lantermans Hildo C, Ma Fangxue, Kuil Annemieke, de Rooij Martin F M, Bergkamp Nick D, van der Meer Werner, van Buul Jaap D, Smit Martine J, Kersten Marie José, Spaargaren Marcel, Pals Steven T

TR-FRET between engineered nanobodies reveals the existence of endogenous CXCR4 oligomers

利用工程纳米抗体之间的时间分辨荧光共振能量转移(TR-FRET)技术揭示了内源性CXCR4寡聚体的存在。

Heuninck, Joyce; Bobkov, Vladimir; Grison, Claire M; Fumagalli, Amos; Lescuyer, Mathias; Otun, Omolade; Bechara, Cherine; Lamarque, Laurent; Trinquet, Eric; Bachelerie, Françoise; Marin, Philippe; Mouillac, Bernard; Granier, Sébastien; van der Woning, Bas; de Haard, Hans; Smit, Martine J; Heukers, Raimond; Durroux, Thierry

Signal termination of the chemokine receptor CCR9 is governed by an arrestin-independent phosphorylation mechanism.

趋化因子受体 CCR9 的信号终止是由一种不依赖于阻遏蛋白的磷酸化机制控制的

Lamme Thomas D, Smit Martine J, Schafer Christopher T

Plasma membrane rather than endosomal Gq signaling drives transcriptional activity by the viral chemokine receptor US28 in glioblastoma

在胶质母细胞瘤中,病毒趋化因子受体US28的转录活性是由质膜而非内体Gq信号传导驱动的。

Daly, Carole; Wright, Adam; Heukers, Raimond; McKee, Chloe M; Coll, Rebecca C; Evergren, Emma; Smit, Martine J; Thomsen, Alex R B; Plouffe, Bianca

G protein-coupled receptors: a gateway to targeting oncogenic EVs?

G蛋白偶联受体:靶向致癌性细胞外囊泡的途径?

Di Niro, Lotte; Linders, Amber C; Glynn, Thomas; Pegtel, D Michiel; Siderius, Marco; Crudden, Caitrin; Smit, Martine J

Molecular characterization of the CXCR4 / CXCR7 axis in germ cell tumors and its targetability using nanobody-drug-conjugates

生殖细胞肿瘤中CXCR4/CXCR7轴的分子特征及其纳米抗体-药物偶联靶向性研究

Wakileh, Gamal A; Bierholz, Philipp; Kotthoff, Mara; Skowron, Margaretha A; Bremmer, Felix; Stephan, Alexa; Anbuhl, Stephanie M; Heukers, Raimond; Smit, Martine J; Ströbel, Philipp; Nettersheim, Daniel

Fusicoccin-A Targets Cancerous Inhibitor of Protein Phosphatase 2A by Stabilizing a C-Terminal Interaction with 14-3-3

Fusicoccin-A 通过稳定与 14-3-3 蛋白的 C 端相互作用来靶向癌性蛋白磷酸酶 2A 抑制剂。

Brink, Hendrik J; van Senten, Jeffrey R; De Vries-van Leeuwen, Ingrid J; da Costa Pereira, Daniel; Piersma, Sander R; Jimenez, Connie R; Centorrino, Federica; Ottmann, Christian; Siderius, Marco; Smit, Martine J; de Boer, Albertus H