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The asymmetric opening of HIV-1 Env by a potent CD4 mimetic enables anti-coreceptor binding site antibodies to mediate ADCC

强效CD4模拟物对HIV-1 Env的不对称打开作用，使得抗辅助受体结合位点抗体能够介导抗体依赖性细胞毒性作用（ADCC）。

Richard, Jonathan; Grunst, Michael W; Niu, Ling; Díaz-Salinas, Marco A; Zhu, Li; Tolbert, William D; Marchitto, Lorie; Zhou, Fei; Bourassa, Catherine; Kim, Hongil; Boodapati, Sri Lakshmi Tejaswi; Yang, Derek; Chiu, Ta Jung; Chen, Hung-Ching; Benlarbi, Mehdi; Beaudoin-Bussières, Guillaume; Gottumukkala, Suneetha; Li, Wenwei; Dionne, Katrina; Bélanger, Étienne; Chatterjee, Debashree; Medjahed, Halima; Hendrickson, Wayne A; Sodroski, Joseph; Lang, Zabrina C; Morton, Abraham J; Huang, Rick K; Matthies, Doreen; Smith, Amos B 3rd; Kumar, Priti; Mothes, Walther; Munro, James B; Pazgier, Marzena; Finzi, Andrés

CD4

Stoichiometry of HIV-1 envelope glycoprotein protomers with changes that stabilize or destabilize the pretriggered conformation

HIV-1包膜糖蛋白原体的化学计量比及其变化对预触发构象的稳定或不稳定的影响

期刊:mBio

影响因子:4.7

doi:10.1128/mbio.01793-25

Zhang, Zhiqing; Anang, Saumya; Wang, Qian; Nguyen, Hanh T; Chen, Hung-Ching; Chiu, Ta-Jung; Yang, Derek; Smith, Amos B 3rd; Sodroski, Joseph G

Soluble CD4 inhibits Ebola virus infection by targeting endosomal receptor-binding site.

可溶性CD4通过靶向内体受体结合位点抑制埃博拉病毒感染

期刊:iScience

影响因子:4.1

doi:10.1016/j.isci.2025.112573

Wang Leah Liu, Keiser Patrick, Yang Derek, Seravalli Javier, Patten J J, Eaton Brett, Anderson Dirk, Liu Yi, Holbrook Michael R, Smith Amos B 3rd, Davey Robert A, Xiang Shi-Hua

Optimization of VE607 to generate analogs with improved neutralization activities against SARS-CoV-2 variants

优化VE607以生成对SARS-CoV-2变种具有更强中和活性的类似物

期刊:Journal of Virology

影响因子:3.8

doi:10.1128/jvi.01034-25

Ding, Shilei; Yang, Derek; Ullah, Irfan; Niu, Ling; Unger, Matthew; Díaz-Salinas, Marco A; Chandravanshi, Monika; Zhou, Fei; Beaudoin-Bussières, Guillaume; Benlarbi, Mehdi; Tolbert, William D; Yoon, Keon-Woong; Xu, Ruixue; Laroche, Geneviève; Gaudette, Fleur; Morton, Abraham J; Lang, Zabrina C; Son, Anna; Abrams, Cameron; Côté, Marceline; Smith, Amos B 3rd; Huang, Rick K; Matthies, Doreen; Munro, James B; Pazgier, Marzena; Uchil, Pradeep D; Finzi, Andrés

SARS-CoV-2

发表日期：2025

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HIV Virion Capturing Liposomes for Therapeutic Vaccination

用于治疗性疫苗的HIV病毒颗粒捕获脂质体

期刊:

影响因子:

doi:10.1101/2025.11.24.690259

Kang, Ted Keunsil; Ang, Charles G; Canziani, Gabriela; Elkateb, Heba; Thomas, Divine; Yang, Derek; Smith, Amos B 3rd; Haddad, Elias K; Chaiken, Irwin; Deak, Peter

Conformational activation and disulfide exchange in HIV-1 Env induce cell-free lytic/fusogenic transformation and enhance infection

HIV-1 Env 的构象激活和二硫键交换可诱导无细胞裂解/融合转化并增强感染。

期刊:Journal of Virology

影响因子:

doi:10.1128/jvi.01471-24

Ang, Charles G; Hyatt, Nadia L; Le Minh, Giang; Gupta, Monisha; Kadam, Manali; Hogg, Philip J; Smith, Amos B 3rd; Chaiken, Irwin M

A gp41 HR2 residue modulates the susceptibility of HIV-1 envelope glycoproteins to small molecule inhibitors targeting gp120

gp41 HR2残基调节HIV-1包膜糖蛋白对靶向gp120的小分子抑制剂的敏感性

期刊:Journal of Virology

影响因子:

doi:10.1128/jvi.02267-24

Chatterjee, Debashree; Niu, Ling; Medjahed, Halima; Ding, Shilei; Benlarbi, Mehdi; Bélanger, Étienne; Prévost, Jérémie; Chen, Hung-Ching; Tolbert, William D; Smith, Amos B 3rd; Pazgier, Marzena; Finzi, Andrés

CD4-mimetics sensitize HIV-infected cells to ADCC mediated by plasma from persons with early-stage HIV-1 infection

CD4 模拟物可使 HIV 感染细胞对早期 HIV-1 感染者血浆介导的 ADCC 更加敏感。

期刊:Journal of Virology

影响因子:

doi:10.1128/jvi.00858-25

Ding, Shilei; Tauzin, Alexandra; Pinto-Santini, Delia; Dasgupta, Sayan; Yang, Derek; Tolbert, William D; Chandravanshi, Monika; Benlarbi, Mehdi; Verly, Myriam; Lama, Javier R; Huryn, Donna M; Smith, Amos B 3rd; Pazgier, Marzena; Finzi, Andrés; Duerr, Ann

Optimization of a Piperidine CD4-Mimetic Scaffold Sensitizing HIV-1 Infected Cells to Antibody-Dependent Cellular Cytotoxicity

优化哌啶类CD4模拟支架，增强HIV-1感染细胞对抗体依赖性细胞毒性的敏感性

期刊:ACS Medicinal Chemistry Letters

影响因子:4

doi:10.1021/acsmedchemlett.4c00403

Lee, Daniel; Niu, Ling; Ding, Shilei; Zhu, Huile; Tolbert, William D; Medjahed, Halima; Beaudoin-Bussières, Guillaume; Abrams, Cameron; Finzi, Andrés; Pazgier, Marzena; Smith, Amos B 3rd

CoO/Co(3)O(4) heterostructures with intimate contact promote photocatalytic CO(2) reduction

具有紧密接触的CoO/Co₃O₄异质结构促进光催化CO₂还原

The asymmetric opening of HIV-1 Env by a potent CD4 mimetic enables anti-coreceptor binding site antibodies to mediate ADCC

强效CD4模拟物对HIV-1 Env的不对称打开作用，使得抗辅助受体结合位点抗体能够介导抗体依赖性细胞毒性作用（ADCC）。

Stoichiometry of HIV-1 envelope glycoprotein protomers with changes that stabilize or destabilize the pretriggered conformation

HIV-1包膜糖蛋白原体的化学计量比及其变化对预触发构象的稳定或不稳定的影响

Soluble CD4 inhibits Ebola virus infection by targeting endosomal receptor-binding site.

可溶性CD4通过靶向内体受体结合位点抑制埃博拉病毒感染

Optimization of VE607 to generate analogs with improved neutralization activities against SARS-CoV-2 variants

优化VE607以生成对SARS-CoV-2变种具有更强中和活性的类似物

HIV Virion Capturing Liposomes for Therapeutic Vaccination

用于治疗性疫苗的HIV病毒颗粒捕获脂质体

Conformational activation and disulfide exchange in HIV-1 Env induce cell-free lytic/fusogenic transformation and enhance infection

HIV-1 Env 的构象激活和二硫键交换可诱导无细胞裂解/融合转化并增强感染。

A gp41 HR2 residue modulates the susceptibility of HIV-1 envelope glycoproteins to small molecule inhibitors targeting gp120

gp41 HR2残基调节HIV-1包膜糖蛋白对靶向gp120的小分子抑制剂的敏感性

CD4-mimetics sensitize HIV-infected cells to ADCC mediated by plasma from persons with early-stage HIV-1 infection

CD4 模拟物可使 HIV 感染细胞对早期 HIV-1 感染者血浆介导的 ADCC 更加敏感。

Optimization of a Piperidine CD4-Mimetic Scaffold Sensitizing HIV-1 Infected Cells to Antibody-Dependent Cellular Cytotoxicity

优化哌啶类CD4模拟支架，增强HIV-1感染细胞对抗体依赖性细胞毒性的敏感性