日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Genetic validation of Leishmania genes essential for amastigote survival in vivo using N-myristoyltransferase as a model

以N-肉豆蔻酰转移酶为模型,对利什曼原虫体内无鞭毛体存活所必需的基因进行遗传验证

Paape, Daniel; Prendergast, Catriona T; Price, Helen P; Doehl, Johannes S P; Smith, Deborah F

Leishmania HASP and SHERP Genes Are Required for In Vivo Differentiation, Parasite Transmission and Virulence Attenuation in the Host.

利什曼原虫 HASP 和 SHERP 基因是宿主体内分化、寄生虫传播和毒力减弱所必需的

Doehl Johannes S P, Sádlová Jovana, Aslan Hamide, Pružinová Kateřina, Metangmo Sonia, Votýpka Jan, Kamhawi Shaden, Volf Petr, Smith Deborah F

A third generation vaccine for human visceral leishmaniasis and post kala azar dermal leishmaniasis: First-in-human trial of ChAd63-KH

用于治疗人类内脏利什曼病和黑热病后皮肤利什曼病的第三代疫苗:ChAd63-KH 的首次人体试验

Osman, Mohamed; Mistry, Anoop; Keding, Ada; Gabe, Rhian; Cook, Elizabeth; Forrester, Sarah; Wiggins, Rebecca; Di Marco, Stefania; Colloca, Stefano; Siani, Loredana; Cortese, Riccardo; Smith, Deborah F; Aebischer, Toni; Kaye, Paul M; Lacey, Charles J

Global Profiling and Inhibition of Protein Lipidation in Vector and Host Stages of the Sleeping Sickness Parasite Trypanosoma brucei

锥虫(Trypanosoma brucei)媒介和宿主阶段蛋白质脂化的全球分析与抑制

Wright, Megan H; Paape, Daniel; Price, Helen P; Smith, Deborah F; Tate, Edward W

Hybridization in Parasites: Consequences for Adaptive Evolution, Pathogenesis, and Public Health in a Changing World

寄生虫杂交:对适应性进化、致病机制和不断变化的世界中的公共卫生的影响

King, Kayla C; Stelkens, Rike B; Webster, Joanne P; Smith, Deborah F; Brockhurst, Michael A

Discovery of high affinity inhibitors of Leishmania donovani N-myristoyltransferase

发现利什曼原虫 N-肉豆蔻酰转移酶的高亲和力抑制剂

Rackham, Mark D; Yu, Zhiyong; Brannigan, James A; Heal, William P; Paape, Daniel; Barker, K Victoria; Wilkinson, Anthony J; Smith, Deborah F; Leatherbarrow, Robin J; Tate, Edward W

Genomic confirmation of hybridisation and recent inbreeding in a vector-isolated Leishmania population

通过基因组学方法证实了媒介隔离的利什曼原虫种群中存在杂交和近期近亲繁殖现象

Rogers, Matthew B; Downing, Tim; Smith, Barbara A; Imamura, Hideo; Sanders, Mandy; Svobodova, Milena; Volf, Petr; Berriman, Matthew; Cotton, James A; Smith, Deborah F

Diverse modes of binding in structures of Leishmania major N-myristoyltransferase with selective inhibitors

利什曼原虫N-肉豆蔻酰转移酶结构中与选择性抑制剂的多种结合模式

Brannigan, James A; Roberts, Shirley M; Bell, Andrew S; Hutton, Jennie A; Hodgkinson, Michael R; Tate, Edward W; Leatherbarrow, Robin J; Smith, Deborah F; Wilkinson, Anthony J

Using a non-image-based medium-throughput assay for screening compounds targeting N-myristoylation in intracellular Leishmania amastigotes

利用非图像处理的中等通量检测方法筛选靶向细胞内利什曼原虫无鞭毛体N-肉豆蔻酰化的化合物

Paape, Daniel; Bell, Andrew S; Heal, William P; Hutton, Jennie A; Leatherbarrow, Robin J; Tate, Edward W; Smith, Deborah F

The Leishmania major BBSome subunit BBS1 is essential for parasite virulence in the mammalian host

利什曼原虫BBSome亚基BBS1对于寄生虫在哺乳动物宿主中的毒力至关重要

Price, Helen P; Paape, Daniel; Hodgkinson, Michael R; Farrant, Katie; Doehl, Johannes; Stark, Meg; Smith, Deborah F