Smith Emery相关文献与解析，生知库 | 链接生命科学的每一步

Stis, Austin E; Lazimi, Charles S; Ferreira, Sandra M; Cuaycal, Alexandra E; Smurlick, Dylan; Hagan, D Walker; Nakayama, Taylor; Gandhi, Sunil P; Smith, Emery; Spicer, Timothy P; Phelps, Edward A

细胞生物学

发表日期：2026

文献求助收藏

Homeostatic scaling of dynorphin signaling by a non-canonical opioid receptor

非经典阿片受体介导的强啡肽信号稳态调节

期刊:Nature Communications

影响因子:15.7

doi:10.1038/s41467-025-62133-x

Li, Xiaona; Winters, Nathan D; Pandey, Shubhi; Lankford, Colten; Stoveken, Hannah M; Smith, Emery; Chang, Chu-Ting; Zucca, Stefano; Scampavia, Louis; Spicer, Timothy; Martemyanov, Kirill A

信号转导

发表日期：2025

文献求助收藏

Target-based discovery of a broad-spectrum flukicide.

基于靶点的广谱杀吸虫剂的发现

期刊:Nature Structural & Molecular Biology

影响因子:10.1

doi:10.1038/s41594-024-01298-3

Sprague Daniel J, Park Sang-Kyu, Gramberg Svenja, Bauer Lisa, Rohr Claudia M, Chulkov Evgeny G, Smith Emery, Scampavia Louis, Spicer Timothy P, Haeberlein Simone, Marchant Jonathan S

发表日期：2024

文献求助收藏

Target-based discovery of a broad spectrum flukicide.

基于靶点的广谱杀吸虫剂的发现

期刊:

影响因子:

doi:10.1101/2023.09.22.559026

Sprague Daniel J, Park Sang-Kyu, Gramberg Svenja, Bauer Lisa, Rohr Claudia M, Chulkov Evgeny G, Smith Emery, Scampavia Louis, Spicer Timothy P, Haeberlein Simone, Marchant Jonathan S

发表日期：2023

文献求助收藏

Identification of novel modulators of a schistosome transient receptor potential channel targeted by praziquantel

鉴定吡喹酮靶向的血吸虫瞬时受体电位通道的新型调节剂

期刊:PLoS Neglected Tropical Diseases

影响因子:3.4

doi:10.1371/journal.pntd.0009898

Chulkov, Evgeny G; Smith, Emery; Rohr, Claudia M; Yahya, Nawal A; Park, Sang-Kyu; Scampavia, Louis; Spicer, Timothy P; Marchant, Jonathan S

信号转导

发表日期：2021

文献求助收藏

Identification of Compounds That Promote Readthrough of Premature Termination Codons in the CFTR

鉴定能促进CFTR中提前终止密码子通读的化合物。

期刊:SLAS Discovery

影响因子:2.7

doi:10.1177/2472555220962001

Smith, Emery; Dukovski, Danijela; Shumate, Justin; Scampavia, Louis; Miller, John P; Spicer, Timothy P

CFTR

发表日期：2021

文献求助收藏

Receptor antagonism/agonism can be uncoupled from pharmacoperone activity

受体拮抗/激动作用可以与药理伴侣活性脱钩。

期刊:Molecular and Cellular Endocrinology

影响因子:3.6

doi:10.1016/j.mce.2016.07.003

Janovick, Jo Ann; Spicer, Timothy P; Smith, Emery; Bannister, Thomas D; Kenakin, Terry; Scampavia, Louis; Conn, P Michael

信号转导

发表日期：2016

文献求助收藏

Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5,6-dimethyl-4-(piperidin-1-yl)thieno[2,3-d]pyrimidine core

基于5,6-二甲基-4-(哌啶-1-基)噻吩并[2,3-d]嘧啶核心结构，发现并优化了一系列新型高中枢神经系统渗透性的M4 PAMs。

期刊:Bioorganic & Medicinal Chemistry Letters

影响因子:2.2

doi:10.1016/j.bmcl.2016.05.010

Wood, Michael R; Noetzel, Meredith J; Engers, Julie L; Bollinger, Katrina A; Melancon, Bruce J; Tarr, James C; Han, Changho; West, Mary; Gregro, Alison R; Lamsal, Atin; Chang, Sichen; Ajmera, Sonia; Smith, Emery; Chase, Peter; Hodder, Peter S; Bubser, Michael; Jones, Carrie K; Hopkins, Corey R; Emmitte, Kyle A; Niswender, Colleen M; Wood, Michael W; Duggan, Mark E; Conn, P Jeffrey; Bridges, Thomas M; Lindsley, Craig W

神经科学

发表日期：2016

文献求助收藏

Discovery and SAR of a novel series of potent, CNS penetrant M4 PAMs based on a non-enolizable ketone core: Challenges in disposition

基于非烯醇化酮核心的新型强效、中枢神经系统穿透性M4 PAMs的发现和构效关系研究：处置方面的挑战

期刊:Bioorganic & Medicinal Chemistry Letters

影响因子:2.2

doi:10.1016/j.bmcl.2016.07.042

Wood, Michael R; Noetzel, Meredith J; Tarr, James C; Rodriguez, Alice L; Lamsal, Atin; Chang, Sichen; Foster, Jarrett J; Smith, Emery; Chase, Peter; Hodder, Peter S; Engers, Darren W; Niswender, Colleen M; Brandon, Nicholas J; Wood, Michael W; Duggan, Mark E; Conn, P Jeffrey; Bridges, Thomas M; Lindsley, Craig W

神经科学

发表日期：2016

文献求助收藏

Discovery and SAR of muscarinic receptor subtype 1 (M1) allosteric activators from a molecular libraries high throughput screen. Part 1: 2,5-dibenzyl-2H-pyrazolo[4,3-c]quinolin-3(5H)-ones as positive allosteric modulators

利用分子库高通量筛选发现毒蕈碱受体亚型1 (M1) 变构激活剂及其构效关系研究。第一部分：2,5-二苄基-2H-吡唑并[4,3-c]喹啉-3(5H)-酮作为正向变构调节剂

期刊:Bioorganic & Medicinal Chemistry Letters

影响因子:2.2

doi:10.1016/j.bmcl.2014.11.011

Han, Changho; Chatterjee, Arindam; Noetzel, Meredith J; Panarese, Joseph D; Smith, Emery; Chase, Peter; Hodder, Peter; Niswender, Colleen; Conn, P Jeffrey; Lindsley, Craig W; Stauffer, Shaun R

信号转导

发表日期：2015

文献求助收藏

Biosensor Cell Array Reveals Temporal GABA Secretion Dynamics from Pancreatic Islets

生物传感器细胞阵列揭示胰岛GABA分泌的时间动态变化

Homeostatic scaling of dynorphin signaling by a non-canonical opioid receptor

非经典阿片受体介导的强啡肽信号稳态调节

Target-based discovery of a broad-spectrum flukicide.

基于靶点的广谱杀吸虫剂的发现

Target-based discovery of a broad spectrum flukicide.

基于靶点的广谱杀吸虫剂的发现

Identification of novel modulators of a schistosome transient receptor potential channel targeted by praziquantel

鉴定吡喹酮靶向的血吸虫瞬时受体电位通道的新型调节剂

Identification of Compounds That Promote Readthrough of Premature Termination Codons in the CFTR

鉴定能促进CFTR中提前终止密码子通读的化合物。

Receptor antagonism/agonism can be uncoupled from pharmacoperone activity

受体拮抗/激动作用可以与药理伴侣活性脱钩。

Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5,6-dimethyl-4-(piperidin-1-yl)thieno[2,3-d]pyrimidine core

基于5,6-二甲基-4-(哌啶-1-基)噻吩并[2,3-d]嘧啶核心结构，发现并优化了一系列新型高中枢神经系统渗透性的M4 PAMs。

Discovery and SAR of a novel series of potent, CNS penetrant M4 PAMs based on a non-enolizable ketone core: Challenges in disposition

基于非烯醇化酮核心的新型强效、中枢神经系统穿透性M4 PAMs的发现和构效关系研究：处置方面的挑战

Discovery and SAR of muscarinic receptor subtype 1 (M1) allosteric activators from a molecular libraries high throughput screen. Part 1: 2,5-dibenzyl-2H-pyrazolo[4,3-c]quinolin-3(5H)-ones as positive allosteric modulators

利用分子库高通量筛选发现毒蕈碱受体亚型1 (M1) 变构激活剂及其构效关系研究。第一部分：2,5-二苄基-2H-吡唑并[4,3-c]喹啉-3(5H)-酮作为正向变构调节剂