Thiopurine Enhanced ALL Maintenance (TEAM): study protocol for a randomized study to evaluate the improvement in disease-free survival by adding very low dose 6-thioguanine to 6-mercaptopurine/methotrexate-based maintenance therapy in pediatric and adult patients (0-45 years) with newly diagnosed B-cell precursor or T-cell acute lymphoblastic leukemia treated according to the intermediate risk-high group of the ALLTogether1 protocol
硫嘌呤增强急性淋巴细胞白血病维持治疗（TEAM）：一项随机研究方案，旨在评估在接受基于 6-巯基嘌呤/甲氨蝶呤的维持治疗方案中，加用极低剂量 6-硫鸟嘌呤能否改善新诊断的 B 细胞前体或 T 细胞急性淋巴细胞白血病（ALL）患儿（0-45 岁）的无病生存期。这些患儿均按照 ALLTogether1 方案的中危-高危组进行治疗。
期刊:BMC Cancer
影响因子:3.4
doi:10.1186/s12885-022-09522-3
Toksvang, Linea Natalie; Als-Nielsen, Bodil; Bacon, Christopher; Bertasiute, Ruta; Duarte, Ximo; Escherich, Gabriele; Helgadottir, Elín Anna; Johannsdottir, Inga Rinvoll; Jónsson, Ólafur G; Kozlowski, Piotr; Langenskjöld, Cecilia; Lepik, Kristi; Niinimäki, Riitta; Overgaard, Ulrik Malthe; Punab, Mari; Räty, Riikka; Segers, Heidi; van der Sluis, Inge; Smith, Owen Patrick; Strullu, Marion; Vaitkevičienė, Goda; Wik, Hilde Skuterud; Heyman, Mats; Schmiegelow, Kjeld
