日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Chaperone-assisted expression and purification of the AML-associated Src-family kinase Fgr in Escherichia coli

在大肠杆菌中利用分子伴侣辅助表达和纯化与急性髓系白血病相关的Src家族激酶Fgr

Gonzalez-Areizaga, Giancarlo; Smithgall, Thomas E

An SH3-binding allosteric modulator stabilizes the global conformation of the AML-associated Src-family kinase, Hck

SH3结合变构调节剂可稳定AML相关Src家族激酶Hck的整体构象。

Selzer, Ari M; Gerlach, Gabriella; Gonzalez-Areizaga, Giancarlo; Wales, Thomas E; Cui, Stephanie Y; Iyer, Prema; Engen, John R; Camacho, Carlos; Ishima, Rieko; Smithgall, Thomas E

Small molecule intervention of actin-binding protein profilin1 reduces tumor angiogenesis in renal cell carcinoma

小分子干预肌动蛋白结合蛋白profilin1可减少肾细胞癌中的肿瘤血管生成

Gau, David; Chawla, Pooja; Xu, Kexin; Welling, Niharika; Antonello, Jacob; Consoli, Caroline; Wei, Monica; Zdancewicz, Sara; DaSilva, Michael; Varghese, Chris; Francoeur, Paul; Shi, Haibin; Chen, Xucai; Paranjape, Anurag; Villanueva, Flordeliza; Smithgall, Thomas E; VanDemark, Andrew; Koes, David R; Huryn, Donna M; Roy, Partha

PROTAC-mediated degradation of HIV-1 Nef efficiently restores cell-surface CD4 and MHC-I expression and blocks HIV-1 replication.

PROTAC介导的HIV-1 Nef降解可有效恢复细胞表面CD4和MHC-I的表达,并阻断HIV-1的复制

Emert-Sedlak Lori A, Tice Colin M, Shi Haibin, Alvarado John J, Shu Sherry T, Reitz Allen B, Smithgall Thomas E

Membrane-bound Merkel cell polyomavirus middle T protein constitutively activates PLCγ1 signaling through Src-family kinases.

膜结合的默克尔细胞多瘤病毒中T蛋白通过Src家族激酶组成性激活PLCγ1信号传导

Peng Wen-Yu, Abere Bizunesh, Shi Haibin, Toland Sabrina, Smithgall Thomas E, Moore Patrick S, Chang Yuan

ODP551 Halting ErbB-2 Isoforms Retrograde Transport to the Nucleus as a New Theragnostic Approach for Triple Negative Breast Cancer

ODP551通过阻断ErbB-2亚型逆向转运至细胞核,为三阴性乳腺癌提供一种新的诊疗一体化策略

Mitchell, Jennifer L; Trible, Ronald P; Emert-Sedlak, Lori A; Weis, David D; Lerner, Edwina C; Applen, Jeremy J; Sefton, Bartholomew M; Smithgall, Thomas E; Engen, John R; Elizalde, Patricia Virginia; Izzo, Franco; Chervo, Maria Florencia; Merin, Sharon Salma; Dupont, Agustina; Chiauzzi, Violeta; Bruni, Sofia; Petrillo, Ezequiel; Montero, Diego; Mercogliano, Maria Florencia; Proietti, Cecilia Jazmin; Schillaci, Roxana; Madera, Santiago; Russo, Rosalia Ines Cordo

Antiretroviral Drug Discovery Targeting the HIV-1 Nef Virulence Factor

针对HIV-1 Nef毒力因子的抗逆转录病毒药物研发

Emert-Sedlak, Lori A; Shi, Haibin; Tice, Colin M; Chen, Li; Alvarado, John J; Shu, Sherry T; Du, Shoucheng; Thomas, Catherine E; Wrobel, Jay E; Reitz, Allen B; Smithgall, Thomas E

In Vitro Evolution Reveals a Single Mutation as Sole Source of Src-Family Kinase C-Helix-out Inhibitor Resistance

体外进化揭示单个突变是Src家族激酶C螺旋外翻抑制剂耐药性的唯一来源。

Patel, Ravi K; Patel, Yash K; Smithgall, Thomas E

Discovery of Non-peptide Small Molecule Allosteric Modulators of the Src-family Kinase, Hck

发现Src家族激酶Hck的非肽类小分子变构调节剂

Dorman, Heather R; Close, David; Wingert, Bentley M; Camacho, Carlos J; Johnston, Paul A; Smithgall, Thomas E

Dynamics of the Tec-family tyrosine kinase SH3 domains

Tec家族酪氨酸激酶SH3结构域的动力学

Roberts, Justin M; Tarafdar, Sreya; Joseph, Raji E; Andreotti, Amy H; Smithgall, Thomas E; Engen, John R; Wales, Thomas E