A randomized proof-of-mechanism trial applying the 'fast-fail' approach to evaluating κ-opioid antagonism as a treatment for anhedonia
一项采用“快速失败”方法的随机机制验证试验,旨在评估κ-阿片受体拮抗剂治疗快感缺失症的疗效。
期刊:Nature Medicine
影响因子:50
doi:10.1038/s41591-020-0806-7
Krystal, Andrew D; Pizzagalli, Diego A; Smoski, Moria; Mathew, Sanjay J; Nurnberger, John Jr; Lisanby, Sarah H; Iosifescu, Dan; Murrough, James W; Yang, Hongqiu; Weiner, Richard D; Calabrese, Joseph R; Sanacora, Gerard; Hermes, Gretchen; Keefe, Richard S E; Song, Allen; Goodman, Wayne; Szabo, Steven T; Whitton, Alexis E; Gao, Keming; Potter, William Z