日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

G protein Gα(q) subunits engage targets in the nucleus involved in chromatin remodeling and gene expression

G蛋白Gα(q)亚基与细胞核内参与染色质重塑和基因表达的靶标结合

Loomis, Joseph; Chandan, Naincy; Burroughs, Michael; Abraham, Saji; Zhang, Rongxi; Cao, Yiyi; Brody, Matthew J; Tall, Gregory G; Smrcka, Alan V

Functional interrogation of cellular Lp(a) uptake by genome-scale CRISPR screening.

利用基因组规模的 CRISPR 筛选对细胞 Lp(a) 摄取进行功能性研究

Khan Taslima G, Bragazzi Cunha Juliana, Raut Chinmay, Burroughs Michael, Vyas Hitarthi S, Leix Kyle, Goonewardena Sascha N, Smrcka Alan V, Speliotes Elizabeth K, Emmer Brian T

Neuromodulation of voltage-gated sodium channels by Gβ1γ2 subunits: Implications for GNB1-linked encephalopathy

Gβ1γ2亚基对电压门控钠通道的神经调控:对GNB1相关脑病的影响

Denomme, Nicholas; Hodges, Samantha L; Lopez-Santiago, Luis; Yuan, Yukun; Ziobro, Julie M; Minton, Joe; Chen, Chunling; Chen, Yan; Hull, Jacob M; Offord, James; Smrcka, Alan V; Isom, Lori L

GoLoco/GPR motif-dependent regulation of Rap1GAP1 by Gα(o) is disrupted by Gα(o) encephalopathy variants.

Gα(o)脑病变异体破坏了Gα(o)对Rap1GAP1的GoLoco/GPR基序依赖性调控

Momplaisir Nathalie L, Chandan Naincy R, Wang Beiyun, Qu Elaine, Smrcka Alan V

Biasing G protein βγ subunit downstream signaling enhances the analgesic effects of endogenous opioid receptor agonists during nitroglycerin-induced thermal hypersensitivity

偏向 G 蛋白 βγ 亚基下游信号传导可增强内源性阿片受体激动剂在硝酸甘油诱导的热痛觉过敏期间的镇痛作用

Mohamed, Farzanna A; Smrcka, Alan V; Jutkiewicz, Emily M

GPR97/ADGRG3 is activated by its tethered peptide agonist and not by steroids to induce neutrophil polarization and migration

GPR97/ADGRG3受体由其连接的肽激动剂而非类固醇激活,从而诱导中性粒细胞极化和迁移。

Bernadyn, Tyler; Kwarcinski, Frank; Chandan, Naincy; Gandhi, Riya; Feng, Yuling; Holinstat, Michael; Parent, Carole A; Smrcka, Alan V; Tall, Gregory G

Internalized β2-Adrenergic Receptors Oppose PLC-Dependent Hypertrophic Signaling

内化的β2-肾上腺素能受体拮抗PLC依赖性肥大信号传导

Wei, Wenhui; Smrcka, Alan V

Biasing Gβγ Downstream Signaling with Gallein Inhibits Development of Morphine Tolerance and Potentiates Morphine-Induced Nociception in a Tolerant State

利用加莱因偏向 Gβγ 下游信号传导可抑制吗啡耐受性的发展,并在耐受状态下增强吗啡诱导的伤害感受。

Sanchez, Gissell A; Smrcka, Alan V; Jutkiewicz, Emily M

Coincident Regulation of PLCβ Signaling by Gq-Coupled and μ-Opioid Receptors Opposes Opioid-Mediated Antinociception

Gq偶联受体和μ-阿片受体对PLCβ信号的协同调控拮抗阿片类药物介导的镇痛作用

Sanchez, Gissell A; Jutkiewicz, Emily M; Ingram, Susan; Smrcka, Alan V

Subcellular β-Adrenergic Receptor Signaling in Cardiac Physiology and Disease

心脏生理和疾病中的亚细胞β-肾上腺素能受体信号传导

Wei, Wenhui; Smrcka, Alan V