日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Cross-modal integration of metabolomics and cardiac functionality captures dynamic metabotoxic effects of doxorubicin in engineered heart tissues

代谢组学与心脏功能跨模态整合揭示了阿霉素在工程化心脏组织中的动态代谢毒性效应

Conte, Federica; Staykova, Doroteya K; Cofiño-Fabres, Carla; Snippert, Danique; van Rooij, Arno; Lefeber, Dirk J; Passier, Robert

Intestinal tuft cell subtypes represent successive stages of maturation driven by crypt-villus signaling gradients

肠道绒毛细胞亚型代表了由隐窝-绒毛信号梯度驱动的连续成熟阶段。

Julian R Buissant des Amorie ,Max A Betjes ,Jochem H Bernink ,Joris H Hageman ,Veerle E Geurts ,Harry Begthel ,Dimitrios Laskaris ,Maria C Heinz ,Ingrid Jordens ,Tiba Vinck ,Ronja M Houtekamer ,Ingrid Verlaan-Klink ,Sascha R Brunner ,Jacco van Rheenen ,Martijn Gloerich ,Hans Clevers ,Sander J Tans ,Jeroen S van Zon ,Hugo J G Snippert

Analysis of experimental colorectal liver metastases identifies distinct proliferation-independent transcriptional programs in micro- versus macrometastases.

对实验性结直肠肝转移的分析表明,微转移和巨转移中存在不同的、与增殖无关的转录程序。

Peters Niek A, Heinz Maria C, Küçükköse Emre, Viergever Bastiaan J, Baars Matthijs, Amini Mojtaba, Huismans Maarten A, Andel Daan, Verheem Andre, Vercoulen Yvonne, Snippert Hugo, Borel Rinkes Inne H M, Kranenburg Onno

APOBEC3A drives deaminase mutagenesis in human gastric epithelium

APOBEC3A驱动人胃上皮细胞脱氨酶突变。

Yohan An # ,Ji-Hyun Lee # ,Joonoh Lim # ,Jeonghwan Youk ,Seongyeol Park ,Ji-Hyung Park ,Kijong Yi ,Taewoo Kim ,Chang Hyun Nam ,Won Hee Lee ,Soo A Oh ,Yoo Jin Bae ,Thomas M Klompstra ,Haeun Lee ,Jinju Han ,Junehwak Lee ,Jung Woo Park ,Jie-Hyun Kim ,Hyunki Kim ,Hugo Snippert ,Bon-Kyoung Koo ,Young Seok Ju

Impact of treatment history on drug resistance of metastatic colorectal cancer organoids

治疗史对转移性结直肠癌类器官耐药性的影响

Huismans, Maarten A; Smabers, Lidwien P; Brunner, Sascha R; van Hoeck, Arne; Kaa, Demi van de; Franken, Ingrid A; Wensink, Emerens; Koster, Jan; Volckmann, Richard; Kranenburg, Onno; Koopman, Miriam; Snippert, Hugo J G; Roodhart, Jeanine M L

BRAF(V600E) augments WNT signaling in colorectal cancer via aberrant DNA methylation.

BRAF(V600E)通过异常DNA甲基化增强结直肠癌中的WNT信号传导

El Bouazzaoui Layla, Bugter Jeroen M, Küçükköse Emre, Verheem André, Post Jasmin B, Fenderico Nicola, Borel Rinkes Inne H M, Snippert Hugo J G, Maurice Madelon M, Kranenburg Onno

BRAF(V600E) maintains the CpG island methylator phenotype, and DNA methylation of PRC2 targets genes in colon cancer.

BRAF(V600E) 维持 CpG 岛甲基化表型,PRC2 的 DNA 甲基化靶向结肠癌基因

El Bouazzaoui Layla, Bugter Jeroen M, Küçükköse Emre, Verheem André, Post Jasmin B, Fenderico Nicola, Borel Rinkes Inne H M, Snippert Hugo J G, Maurice Madelon M, Kranenburg Onno

Multi-range ERK responses shape the proliferative trajectory of single cells following oncogene induction

多范围 ERK 反应塑造致癌基因诱导后单细胞的增殖轨迹

Jia-Yun Chen, Clemens Hug, José Reyes, Chengzhe Tian, Luca Gerosa, Fabian Fröhlich, Bas Ponsioen, Hugo J G Snippert, Sabrina L Spencer, Ashwini Jambhekar, Peter K Sorger, Galit Lahav

Co-cultures of colon cancer cells and cancer-associated fibroblasts recapitulate the aggressive features of mesenchymal-like colon cancer

结肠癌细胞与癌症相关成纤维细胞的共培养重现了间充质样结肠癌的侵袭性特征

Esther Strating, Mathijs P Verhagen, Emerens Wensink, Ester Dünnebach, Liza Wijler, Itziar Aranguren, Alberto Sanchez De la Cruz, Niek A Peters, Joris H Hageman, Mirjam M C van der Net, Susanne van Schelven, Jamila Laoukili, Riccardo Fodde, Jeanine Roodhart, Stefan Nierkens, Hugo Snippert, Martijn G

Efficient and error-free fluorescent gene tagging in human organoids without double-strand DNA cleavage

无需双链DNA切割即可在人类类器官中实现高效、无错的荧光基因标记

Yannik Bollen,Joris H Hageman,Petra van Leenen,Lucca L M Derks,Bas Ponsioen,Julian R Buissant des Amorie,Ingrid Verlaan-Klink,Myrna van den Bos,Leon W M M Terstappen,Ruben van Boxtel,Hugo J G Snippert