日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Regionally mapped astrocytic responses to cortical and white matter stroke show differential roles in astrocyte-induced vascular remodeling

区域性星形胶质细胞对皮质和白质卒中的反应显示出在星形胶质细胞诱导的血管重塑中不同的作用

Amy J Gleichman ,Riki Kawaguchi ,Elle M Rathbun ,Michael V Sofroniew ,S Thomas Carmichael

How to build the virtual cell with artificial intelligence: Priorities and opportunities

如何利用人工智能构建虚拟细胞:优先事项和机遇

Bunne, Charlotte; Roohani, Yusuf; Rosen, Yanay; Gupta, Ankit; Zhang, Xikun; Roed, Marcel; Alexandrov, Theo; AlQuraishi, Mohammed; Brennan, Patricia; Burkhardt, Daniel B; Califano, Andrea; Cool, Jonah; Dernburg, Abby F; Ewing, Kirsty; Fox, Emily B; Haury, Matthias; Herr, Amy E; Horvitz, Eric; Hsu, Patrick D; Jain, Viren; Johnson, Gregory R; Kalil, Thomas; Kelley, David R; Kelley, Shana O; Kreshuk, Anna; Mitchison, Tim; Otte, Stephani; Shendure, Jay; Sofroniew, Nicholas J; Theis, Fabian; Theodoris, Christina V; Upadhyayula, Srigokul; Valer, Marc; Wang, Bo; Xing, Eric; Yeung-Levy, Serena; Zitnik, Marinka; Karaletsos, Theofanis; Regev, Aviv; Lundberg, Emma; Leskovec, Jure; Quake, Stephen R

Derivation and transcriptional reprogramming of border-forming wound repair astrocytes after spinal cord injury or stroke in mice

小鼠脊髓损伤或中风后边界形成伤口修复星形胶质细胞的衍生和转录重编程

Timothy M O'Shea, Yan Ao, Shinong Wang, Yilong Ren, Amy L Cheng, Riki Kawaguchi, Zechuan Shi, Vivek Swarup, Michael V Sofroniew

Reactive Astrocytes and Emerging Roles in Central Nervous System (CNS) Disorders

反应性星形胶质细胞及其在中枢神经系统疾病中的新兴作用

Liddelow, Shane A; Olsen, Michelle L; Sofroniew, Michael V

Astrocytes in human central nervous system diseases: a frontier for new therapies

星形胶质细胞在人类中枢神经系统疾病中的作用:新疗法的前沿领域

Verkhratsky, Alexei; Butt, Arthur; Li, Baoman; Illes, Peter; Zorec, Robert; Semyanov, Alexey; Tang, Yong; Sofroniew, Michael V

A toolbox of astrocyte-specific, serotype-independent adeno-associated viral vectors using microRNA targeting sequences

利用microRNA靶向序列构建的星形胶质细胞特异性、血清型非依赖性腺相关病毒载体工具箱

Amy J Gleichman ,Riki Kawaguchi ,Michael V Sofroniew ,S Thomas Carmichael

Divergent transcriptional regulation of astrocyte reactivity across disorders

不同疾病中星形胶质细胞反应性的转录调控存在差异

Joshua E Burda #, Timothy M O'Shea #, Yan Ao, Keshav B Suresh, Shinong Wang, Alexander M Bernstein, Ashu Chandra, Sandeep Deverasetty, Riki Kawaguchi, Jae H Kim, Sarah McCallum, Alexandra Rogers, Shalaka Wahane, Michael V Sofroniew

CRISPRi screens in human iPSC-derived astrocytes elucidate regulators of distinct inflammatory reactive states

利用CRISPRi技术筛选人iPSC衍生的星形胶质细胞,可以阐明不同炎症反应状态的调节因子。

Kun Leng ,Indigo V L Rose ,Hyosung Kim ,Wenlong Xia ,Wilber Romero-Fernandez ,Brendan Rooney ,Mark Koontz ,Emmy Li ,Yan Ao ,Shinong Wang ,Mitchell Krawczyk ,Julia Tcw ,Alison Goate ,Ye Zhang ,Erik M Ullian ,Michael V Sofroniew ,Stephen P J Fancy ,Matthew S Schrag ,Ethan S Lippmann ,Martin Kampmann

Transcription factor network analysis identifies REST/NRSF as an intrinsic regulator of CNS regeneration in mice

转录因子网络分析表明,REST/NRSF是小鼠中枢神经系统再生过程中的内在调控因子。

Yuyan Cheng # ,Yuqin Yin # ,Alice Zhang ,Alexander M Bernstein ,Riki Kawaguchi ,Kun Gao ,Kyra Potter ,Hui-Ya Gilbert ,Yan Ao ,Jing Ou ,Catherine J Fricano-Kugler ,Jeffrey L Goldberg ,Zhigang He ,Clifford J Woolf ,Michael V Sofroniew ,Larry I Benowitz ,Daniel H Geschwind

Reactive astrocytes transduce inflammation in a blood-brain barrier model through a TNF-STAT3 signaling axis and secretion of alpha 1-antichymotrypsin

反应性星形胶质细胞通过TNF-STAT3信号通路和α1-抗胰凝乳蛋白酶的分泌,在血脑屏障模型中传递炎症信号。

Hyosung Kim ,Kun Leng ,Jinhee Park ,Alexander G Sorets ,Suil Kim ,Alena Shostak ,Rebecca J Embalabala ,Kate Mlouk ,Ketaki A Katdare ,Indigo V L Rose ,Sarah M Sturgeon ,Emma H Neal ,Yan Ao ,Shinong Wang ,Michael V Sofroniew ,Jonathan M Brunger ,Douglas G McMahon ,Matthew S Schrag ,Martin Kampmann ,Ethan S Lippmann