日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Altered MDC1 Interactions and Dysfunctional DNA Repair in Lobular Breast Cancer Confers Sensitivity to PARP Inhibition.

小叶乳腺癌中 MDC1 相互作用的改变和 DNA 修复功能障碍赋予了其对 PARP 抑制剂的敏感性。

Sottnik Joseph L, Shackleford Madeleine T, Nesiba Camryn S, Richer Amanda L, Fleischmann Zoe, Swartz Jordan M, Rowland Carmen E, Musick Maggie, Fu Rui, Myler Logan R, Opresko Patricia L, Mehrotra Sanjana, Sokol Ethan S, Hesselberth Jay R, Diamond Jennifer R, Sikora Matthew J

PI3Kα Inhibitor and Degrader Inavolisib Can Co-opt FGFR2 to Enhance Responses in Patients with PIK3CA-Mutated Solid Tumors and in Preclinical Models.

PI3Kα抑制剂和降解剂Inavolisib可利用FGFR2增强PIK3CA突变实体瘤患者和临床前模型的疗效。

Juric Dejan, Song Kyung, Johnson Radia M, Accordino Melissa K, Bedard Philippe L, Cervantes Andrés, Gambardella Valentina, Hamilton Erika, Italiano Antoine, Kalinsky Kevin, Krop Ian E, Oliveira Mafalda, Saura Cristina, Schmid Peter, Turner Nicholas C, Varga Andreea, Gendreau Steven, Hwang Michael S, Kuang Zheng, Lau Jeffrey T, Lin Eva, Pham Trang, Maddalo Danilo, Rees Matthew G, Ronan Melissa M, Roth Jennifer A, Martin Scott, Sodir Nicole M, Sokol Ethan S, Whitfield Zachary J, Wong Alice, Yauch Robert L, Aimi Junko, Cheeti Sravanthi, Fredrickson Jill, Hilz Stephanie, Hafner Marc, Hutchinson Katherine E, Jin Yanling, Peters Ubong, Zingg Daniel, Royer-Joo Stephanie, Shankar Noopur, Schutzman Jennifer L, Jhaveri Komal L, Dey Anwesha

Clinicogenomic Landscape and Function of PIK3CA, AKT1, and PTEN Mutations in Breast Cancer

乳腺癌中PIK3CA、AKT1和PTEN突变的临床基因组图谱和功能

Tao, Jacqueline J; Sisoudiya, Saumya D; Tukachinsky, Hanna; Schrock, Alexa B; Ebot, Ericka M; Sivakumar, Smruthy; Sokol, Ethan S; Vasan, Neil

Cancer genomic profiling predicts pathogenicity of BRCA1 and BRCA2 variants

癌症基因组分析预测BRCA1和BRCA2变异的致病性

Kondrashova, Olga; Johnston, Rebecca L; Parsons, Michael T; Davidson, Aimee L; Canson, Daffodil M; Tran, Khoa A; Cline, Melissa S; Waddell, Nicola; Sivakumar, Smruthy; Sokol, Ethan S; Jin, Dexter X; Pavlick, Dean C; Decker, Brennan; Frampton, Garrett M; Spurdle, Amanda B

Ligand-activated EGFR/MAPK signaling but not PI3K, are key resistance mechanisms to EGFR-therapy in colorectal cancer.

配体激活的 EGFR/MAPK 信号通路(而非 PI3K)是结直肠癌中 EGFR 疗法产生耐药性的关键机制

Qu Xueping, Hamidi Habib, Johnson Radia M, Sokol Ethan S, Lin Eva, Eng Cathy, Kim Tae Won, Bendell Johanna, Sivakumar Smruthy, Kaplan Benjamin, de Sousa E Melo Felipe, Mancini Andrew, Wongchenko Matthew, Shi Yi, Shames David, Yan Yibing, Ciardiello Fortunato, Bais Carlos

IRS2 as a driver of brain metastasis in colorectal cancer: A potential target for novel therapeutic strategies.

IRS2 作为结直肠癌脑转移的驱动因素:一种潜在的新型治疗策略靶点

Greenberg Inbal, Khair-Dabour Fayhaa, Merenbakh-Lamin Keren, Sokol Ethan S, Goldberg Anat Klein, Simkin Dor, Spitzer Avishay, Benhamou Moshe, Bar-Shira Shai, Raz Michal, Grossman Rachel, Yeini Eilam, Ofek Paula, Meirson Tomer, Satchi-Fainaro Ronit, Reuveni Hadas, Wolf Ido, Rubinek Tami

Correction: Effectiveness of PARP Inhibitor Maintenance Therapy in Ovarian Cancer by BRCA1/2 and a Scar-Based HRD Signature in Real-World Practice

更正:真实世界实践中基于BRCA1/2和瘢痕组织HRD特征的卵巢癌患者接受PARP抑制剂维持治疗的有效性

Richardson, Debra L; Quintanilha, Julia C F; Danziger, Natalie; Li, Gerald; Sokol, Ethan; Schrock, Alexa B; Ebot, Ericka; Bhardwaj, Neeru; Norris, Tanesha; Afghahi, Anosheh; Frachioni, Anthony; Washington, Christina; Dockery, Lauren; Elvin, Julia; Graf, Ryon P; Moore, Kathleen N

Clinical Context Shapes the Relationship between Genomic Alterations and Response to AR Inhibitors and Chemotherapy in Metastatic Prostate Cancer.

临床背景决定了转移性前列腺癌中基因组改变与 AR 抑制剂和化疗反应之间的关系

Shah Kalpit, Secrest Matthew H, Zhou Wei, Wang Shu, Canter Dan, Zhang Yuxiang, Jin Dexter, Sokol Ethan, Nowicka Malgorzata, Ang Houle Armande, Metcalfe Ciara, Gendreau Steven, Schröder Carsten, Wongchenko Matthew, Attard Gerhardt

Tissue-based genomic profiling of 300,000 tumors highlights the detection of variants with low allele fraction

对 30 万个肿瘤进行基于组织的基因组分析,突显了低等位基因频率变异的检测。

Sisoudiya, Saumya D; Tukachinsky, Hanna; Keller-Evans, Rachel B; Schrock, Alexa B; Huang, Richard S P; Gjoerup, Ole; Pishvaian, Michael J; Shroff, Rachna; Sokol, Ethan S; Dennis, Lucas; Frampton, Garrett M; Sivakumar, Smruthy

Retrospective comparison between breast cancer tissue- and blood-based next-generation sequencing results in detection of PIK3CA, AKT1, and PTEN alterations

回顾性比较基于乳腺癌组织和血液的二代测序结果,以检测PIK3CA、AKT1和PTEN的改变

Chaki, Moumita; Benrashid, Mona; Puri, Subir; Sivakumar, Smruthy; Sokol, Ethan S; Briceno, Josefa M; Neil Vasan