Activation of IRF3 in cardiomyocytes impairs mitochondrial oxidative function through PGC-1α inhibition and drives heart failure.
心肌细胞中 IRF3 的激活通过抑制 PGC-1α 损害线粒体氧化功能,从而导致心力衰竭。
期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-026-69792-4
Kumari Manju, Evangelakos Ioannis, Deshpande Anushka, De Jong Kirstie A, Schmiedel Nesrin, Palacio-Escat Nicolà s, Chaves-Filho Adriano de Britto, Frias-Soler Roberto Carlos, Klinke Glynis, Roh Hyun Cheol, Lange Luisa, Berlin Michael, Fuh Marceline M, Buss Jakob Johannes, Tian Tian, Lerchenmüller Carolin, Freichel Marc, Schulze Almut, Nikolaev Viacheslav O, Eschenhagen Thomas, Rosen Evan D, Scheja Ludger, Rangrez Ashraf Yusuf, Heeren Joerg, Frey Norbert