日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Explainable AI-based analysis of human pancreas sections identifies traits of type 2 diabetes.

基于可解释人工智能的人类胰腺切片分析可识别 2 型糖尿病的特征。

Klein Lukas, Ziegler Sebastian, Gerst Felicia, Morgenroth Yanni, Gotkowski Karol, Schöniger Eyke, Heni Martin, Kipke Nicole, Friedland Daniela, Seiler Annika, Geibelt Ellen, Yamazaki Hajime, Häring Hans-Ulrich, Wagner Silvia, Nadalin Silvio, Königsrainer Alfred, Mihaljevic Andre L, Hartmann Daniel, Fend Falko, Aust Daniela, Weitz Jürgen, Jumpertz-von Schwartzenberg Reiner, Distler Marius, Maier-Hein Klaus, Birkenfeld Andreas L, Ullrich Susanne, Jäger Paul F, Isensee Fabian, Solimena Michele, Wagner Robert

Large-scale endoplasmic reticulum membrane solidification spatially organises proteins under thermal or metabolic stress

大规模内质网膜固化可在热应激或代谢应激下对蛋白质进行空间组织。

Müller, Paul M; Mikolaj, Melissa R; Belbaraka, Elmehdi; Hartstein, Finn; Altinoluk, Sophia; Perder, Björn; Trnka, Philipp; Welke, Robert-William; Naumann, Heike; Taudien, Nina; Kunz, Severine; Solimena, Michele; Levental, Ilya; Levental, Kandice R; Müller, Andreas; Ewers, Helge; Narayan, Kedar; Rocks, Oliver

Prevention of type 2 diabetes through prediabetes remission without weight loss

通过缓解糖尿病前期症状而不减轻体重来预防2型糖尿病

Sandforth, Arvid; Arreola, Elsa Vazquez; Hanson, Robert L; Wewer Albrechtsen, Nicolai J; Holst, Jens Juul; Ahrends, Robert; Coman, Cristina; Gerst, Felicia; Lorza-Gil, Estela; Cheng, Yurong; Sandforth, Leontine; Katzenstein, Sarah; Ganslmeier, Marlene; Seissler, Jochen; Hauner, Hans; Perakakis, Nikolaos; Wagner, Robert; Machann, Jürgen; Schick, Fritz; Peter, Andreas; Lehmann, Rainer; Weigert, Cora; Maurer, Jennifer; Preissl, Hubert; Heni, Martin; Szendrödi, Julia; Kopf, Stefan; Solimena, Michele; Schwarz, Peter; Blüher, Matthias; Häring, Hans-Ulrich; Hrabé de Angelis, Martin; Schürmann, Annette; Kabisch, Stefan; Mai, Knut; Pfeiffer, Andreas F H; Bornstein, Stefan; Stumvoll, Michael; Roden, Michael; Stefan, Norbert; Fritsche, Andreas; Birkenfeld, Andreas L; Jumpertz von Schwartzenberg, Reiner

Aldolase-regulated G3BP1/2+ condensates control insulin mRNA storage in beta cells

醛缩酶调节的G3BP1/2+缩合物控制β细胞中胰岛素mRNA的储存。

Esteban Quezada ,Klaus-Peter Knoch ,Jovana Vasiljevic ,Annika Seiler ,Akshaye Pal ,Abishek Gunasekaran ,Carla Münster ,Daniela Friedland ,Eyke Schöniger ,Anke Sönmez ,Pascal Roch ,Carolin Wegbrod ,Katharina Ganß ,Nicole Kipke ,Simon Alberti ,Rita Nano ,Lorenzo Piemonti ,Daniela Aust ,Jürgen Weitz ,Marius Distler ,Michele Solimena

Somatostatin triggers local cAMP and Ca(2+) signaling in primary cilia to modulate pancreatic β-cell function.

生长抑素触发初级纤毛中的局部 cAMP 和 Ca(2+) 信号,从而调节胰腺 β 细胞功能

Nilsson Ceren Incedal, Dumral Özge, Sanchez Gonzalo, Xie Beichen, Müller Andreas, Solimena Michele, Ren Huixia, Idevall-Hagren Olof

Glucose metabolism after distal pancreatectomy - deterioration of beta cell function becomes noticeable at an early stage: a retrospective cohort study

远端胰腺切除术后葡萄糖代谢——β细胞功能恶化在早期阶段即可显现:一项回顾性队列研究

Kalandarishvili, Mikheil; Oehme, Florian; Radulova-Mauersberger, Olga; Kipke, Nicole; Solimena, Michele; Teske, Christian; Mibelli, Nicolas; Weitz, Jürgen; Distler, Marius; Hempel, Sebastian

GLP-1R associates with VAPB and SPHKAP at ERMCSs to regulate β-cell mitochondrial remodelling and function

GLP-1R 与 VAPB 和 SPHKAP 在 ERMCSs 处结合,从而调节 β 细胞线粒体重塑和功能。

Austin, Gregory; Oqua, Affiong I; El Eid, Liliane; Zhu, Mingli; Manchanda, Yusman; Peres, Priyanka; Coyle, Helena; Poliakova, Yelyzaveta; Bouzakri, Karim; Montoya, Alex; Withers, Dominic J; Solimena, Michele; Jones, Ben; Millership, Steven J; Burgold, Steffen; Gaboriau, David C A; Majorovits, Endre; Garlick, Evelyn; Lima, Maria; Prokopenko, Inga; Nixon-Abell, Jonathon; Müller, Andreas; Tomas, Alejandra

OSBP-mediated PI(4)P-cholesterol exchange at endoplasmic reticulum-secretory granule contact sites controls insulin secretion

OSBP介导的内质网分泌颗粒接触点的PI(4)P-胆固醇交换控制胰岛素分泌

Styliani Panagiotou, Kia Wee Tan, Phuoc My Nguyen, Andreas Müller, Affiong Ika Oqua, Alejandra Tomas, Anna Wendt, Lena Eliasson, Anders Tengholm, Michele Solimena, Olof Idevall-Hagren

Purification of time-resolved insulin granules reveals proteomic and lipidomic changes during granule aging

时间分辨胰岛素颗粒的纯化揭示了颗粒老化过程中蛋白质组学和脂质组学的变化

Martin Neukam, Pia Sala, Andreas-David Brunner, Katharina Ganß, Alessandra Palladini, Michal Grzybek, Oleksandra Topcheva, Jovana Vasiljević, Johannes Broichhagen, Kai Johnsson, Thomas Kurth, Matthias Mann, Ünal Coskun, Michele Solimena

Fast Track Adaptation of Oncolytic Coxsackie B3 Virus to Resistant Colorectal Cancer Cells - a Method to Personalize Virotherapy

溶瘤柯萨奇 B3 病毒快速适应耐药结肠直肠癌细胞 - 一种个性化病毒疗法

Leslie Elsner, Lisanne Heimann, Anja Geisler, Babette Dieringer, Klaus-Peter Knoch, Luisa Hinze, Karin Klingel, Michel Solimena, Jens Kurreck, Henry Fechner