日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A high-throughput assay platform to discover small molecule activators of the phospholipase PLC-γ2 to treat Alzheimer's disease.

用于发现磷脂酶 PLC-γ2 小分子激活剂以治疗阿尔茨海默病的高通量检测平台

Carr Adam J, Hajicek Nicole, Tsai Andy P, Acharya Padam P, Hardy P Brian, Meyer Emma, Wyss-Coray Tony, Pearce Kenneth H, Sondek John, Zhang Qisheng

Optogenetic control of PLC-γ1 activity polarizes cell motility

光遗传学控制PLC-γ1活性可极化细胞运动

Appalabhotla, Ravikanth; Siesser, Priscila F; Truscott, Harrison; Hajicek, Nicole; Sondek, John; Bear, James E; Haugh, Jason M

Hyperactive PLCG1 drives non-canonical signaling to promote cell survival

PLCG1过度活跃驱动非经典信号通路,从而促进细胞存活

Zeng, Longhui; Zhang, Xinyan; Xiong, Yiwei; Sato, Kazuki; Hajicek, Nicole; Sondek, John; Su, Xiaolei

Fluorogenic XY-69 in Lipid Vesicles for Measuring Activity of Phospholipase C Isozymes

脂质体中的荧光XY-69用于测量磷脂酶C同工酶的活性

Carr, Adam J; Siraliev-Perez, Edhriz; Huang, Weigang; Sondek, John; Zhang, Qisheng

Article Watch: December, 2020

文章观察:2020年12月

Marston, Daniel J; Vilela, Marco; Huh, Jaewon; Ren, Jinqi; Azoitei, Mihai L; Glekas, George; Danuser, Gaudenz; Sondek, John; Hahn, Klaus M

Spatiotemporal dynamics of GEF-H1 activation controlled by microtubule- and Src-mediated pathways

微管和Src介导的通路控制GEF-H1激活的时空动态

Azoitei, Mihai L; Noh, Jungsik; Marston, Daniel J; Roudot, Philippe; Marshall, Christopher B; Daugird, Timothy A; Lisanza, Sidney L; Sandí, María-José; Ikura, Mitsu; Sondek, John; Rottapel, Robert; Hahn, Klaus M; Danuser, Gaudenz

Potent and Selective Peptide-based Inhibition of the G Protein Gαq

高效且选择性的基于肽的G蛋白Gαq抑制剂

Charpentier, Thomas H; Waldo, Gary L; Lowery-Gionta, Emily G; Krajewski, Krzysztof; Strahl, Brian D; Kash, Thomas L; Harden, T Kendall; Sondek, John

Membrane-induced allosteric control of phospholipase C-β isozymes

膜诱导的磷脂酶C-β同工酶的变构控制

Charpentier, Thomas H; Waldo, Gary L; Barrett, Matthew O; Huang, Weigang; Zhang, Qisheng; Harden, T Kendall; Sondek, John

A cell-permeable inhibitor to trap Gαq proteins in the empty pocket conformation

一种可透过细胞膜的抑制剂,用于将Gαq蛋白捕获在空口袋构象中。

Schmitz, Anna-Lena; Schrage, Ramona; Gaffal, Evelyn; Charpentier, Thomas H; Wiest, Johannes; Hiltensperger, Georg; Morschel, Julia; Hennen, Stephanie; Häußler, Daniela; Horn, Velten; Wenzel, Daniela; Grundmann, Manuel; Büllesbach, Katrin M; Schröder, Ralf; Brewitz, H Henning; Schmidt, Johannes; Gomeza, Jesús; Galés, Céline; Fleischmann, Bernd K; Tüting, Thomas; Imhof, Diana; Tietze, Daniel; Gütschow, Michael; Holzgrabe, Ulrike; Sondek, John; Harden, T Kendall; Mohr, Klaus; Kostenis, Evi

The phospholipase C isozymes and their regulation

磷脂酶C同工酶及其调控

Gresset, Aurelie; Sondek, John; Harden, T Kendall