Directed evolution of novel AAV variants using the MCMS library for enhanced CNS tropism and reduced liver targeting in mice.
利用 MCMS 文库对新型 AAV 变体进行定向进化，以增强其对中枢神经系统的嗜性并减少其对小鼠肝脏的靶向性
期刊:Molecular Therapy-Methods & Clinical Development
影响因子:4.7
doi:10.1016/j.omtm.2025.101522
Song Qingkai, Wu Jiamei, Zhang Qingfeng, Wu Shufang, Luo Xin, Xu Mengmeng, Xu Yinxia, Wang Gang, Yu Hang, Chen Hui, Lu Zhike, Ma Lijia
