日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

siRNA conjugate with high albumin affinity and degradation resistance for delivery and treatment of arthritis in mice and guinea pigs

用于小鼠和豚鼠关节炎递送和治疗的具有高白蛋白亲和力和抗降解性的siRNA偶联物

Juan M Colazo ,Megan C Keech ,Veeraj Shah ,Ella N Hoogenboezem ,Justin H Lo ,Nora Francini ,Nina T Cassidy ,Fang Yu ,Alexander G Sorets ,Joshua T McCune ,Carlisle R DeJulius ,Hongsik Cho ,Danielle L Michell ,Tristan Maerz ,Kacey C Vickers ,Katherine N Gibson-Corley ,Karen A Hasty ,Leslie J Crofford ,Rebecca S Cook ,Craig L Duvall

Elucidating brain transport pathways and cell type-dependent gene silencing of a durable lipid-siRNA conjugate administered into cerebrospinal fluid.

阐明脑脊液中注入的持久性脂质-siRNA缀合物的脑运输途径和细胞类型依赖性基因沉默

Sorets Alexander G, Schwensen Katrina R, Francini Nora, Kjar Andrew, Abdulrahman Adam M, Shostak Alena, Katdare Ketaki A, Schoch Kathleen M, Cowell Rebecca P, Park Joshua C, Ligocki Alexander P, Ford William T, Ventura-Antunes Lissa, Hoogenboezem Ella N, Prusky Alex, Castleberry Mark, Michell Danielle L, Fritsch Emma, Lyons Sarah M, Miller Timothy M, Vickers Kasey C, Schrag Matthew S, Duvall Craig L, Lippmann Ethan S

IQGAP2 regulates blood-brain barrier immune dynamics

IQGAP2 调节血脑屏障免疫动力学

Katdare, Ketaki A; Kjar, Andrew; O'Brown, Natasha M; Neal, Emma H; Sorets, Alexander G; Shostak, Alena; Romero-Fernandez, Wilber; Kwiatkowski, Alexander J; Mlouk, Kate; Kim, Hyosung; Cowell, Rebecca P; Schwensen, Katrina R; Carvajal Tapia, Cristian O; Venslovaite, Guste; Horner, Kensley B; Wilson, John T; Schrag, Matthew S; Megason, Sean G; Lippmann, Ethan S

Beyond mood screening: a pilot study of emotional, cognitive, and somatic concerns in patients with Long COVID

超越情绪筛查:一项针对新冠长期症状患者的情绪、认知和躯体问题的初步研究

Sorets, Tali R; Finley, John-Christopher A; LaFrance, W Curt Jr; Patten, Ryan Van; Mordecai, Kristen; Jimenez, Millenia; Suchy, Stephen; Cahan, Joshua; Koralnik, Igor J; Cherney, Leora R; Cotton, Erica

Financing drug development via adaptive platform trials

通过适应性平台试验为药物研发提供资金

Cho, Joonhyuk; Sorets, Eugene; Chaudhuri, Shomesh; De Mattos, Annette; Drake, Kristin; Cudkowicz, Merit E; Ortiz, Ricardo; Hasenoehrl, Meredith; Chase, Marianne; Harkey, Brittney; Paganoni, Sabrina; Frishkopf, John; Lo, Andrew W

Evaluating the effects of aging on biodistribution and gene silencing activity of lipid-siRNA conjugates delivered into cerebrospinal fluid

评估衰老对递送至脑脊液中的脂质-siRNA缀合物的生物分布和基因沉默活性的影响

Ligocki, Alexander P; Sorets, Alexander G; Abdulrahman, Adam M; Francini, Nora; Park, Joshua C; Lee, Ju Ha; Ford, William T; Lyons, Sarah M; Fritsch, Emma L; Lamantia, Zachary E; Christov, Plamen P; Duvall, Craig L; Lippmann, Ethan S

Intravenous lipid-siRNA conjugate mediates gene silencing at the blood-brain barrier and blood-CSF barrier.

静脉注射脂质-siRNA偶联物可介导血脑屏障和血脑脊液屏障处的基因沉默

Sorets Alexander G, Schwensen Katrina R, Francini Nora, Kjar Andrew, Lyons Sarah, Park Joshua C, Palmer Dillon, Abdulrahman Adam M, Cowell Rebecca P, Katdare Ketaki A, Hoogenboezem Ella N, Wang Angela, Dani Neil, Duvall Craig L, Lippmann Ethan S

Fabrication of endothelialized capillary-like microchannel networks using sacrificial thermoresponsive microfibers

利用牺牲热敏微纤维制造内皮化毛细血管状微通道网络

John A Rector Iv, Lucas McBride, Callie M Weber, Kira Grossman, Alexander Sorets, Lissa Ventura-Antunes, Isabella Holtz, Katherine Young, Matthew Schrag, Ethan S Lippmann, Leon M Bellan

Cognitive functioning in patients with neuro-PASC: the role of fatigue, mood, and hospitalization status

神经系统PASC患者的认知功能:疲劳、情绪和住院状态的作用

Cahan, Joshua; Finley, John-Christopher A; Cotton, Erica; Orban, Zachary S; Jimenez, Millenia; Weintraub, Sandra; Sorets, Tali; Koralnik, Igor J

Lipid-siRNA conjugate accesses perivascular transport and achieves durable knockdown throughout the central nervous system

脂质-siRNA 结合物可进入血管周围运输并在整个中枢神经系统中实现持久敲低

Alexander G Sorets, Katrina R Schwensen, Nora Francini, Andrew Kjar, Adam M Abdulrahman, Alena Shostak, Ketaki A Katdare, Kathleen M Schoch, Rebecca P Cowell, Joshua C Park, Alexander P Ligocki, William T Ford, Lissa Ventura-Antunes, Ella N Hoogenboezem, Alex Prusky, Mark Castleberry, Danielle L Mic