日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Genome-Wide CRISPR Screens Identify ABCG2-Mediated Drug Resistance to the Threonine Tyrosine Kinase (TTK) Inhibitor CFI-402257 in Breast Cancer

全基因组 CRISPR 筛选发现乳腺癌中 ABCG2 介导的对苏氨酸酪氨酸激酶 (TTK) 抑制剂 CFI-402257 的耐药性

Thu, Kelsie L; Jafari, Soode; Silvester, Jennifer; Cruickshank, Jennifer; Soria-Bretones, Isabel; Hodgson, Kelsey; Tobin, Chantal; Haight, Jillian; Lau, Asa P Y; Bray, Tessa; Wakeham, Drew; Bray, Mark R; Mak, Tak W; Cescon, David W

The PLK4 inhibitor RP-1664 demonstrates potent single-agent efficacy in neuroblastoma models through a dual mechanism of sensitivity.

PLK4 抑制剂 RP-1664 通过双重敏感性机制在神经母细胞瘤模型中表现出强大的单药疗效

Maris John, Soria-Bretones Isabel, Casás-Selves Matias, Samanta Minu, Groff David, Murray Jayne, Fletcher Jamie, Farrel Alvin, Pastor Steven, Patel Khushbu, Goodfellow Elliot Goodfellow, Li Li, Caron Cathy, Shiwram Ariya, Kim Hyeyeon, Henry Danielle, Laterreur Nancy, Bowlan Julian, Krytska Kateryna, Neuhauser Steven, Stearns Timothy, Schubert Jeffrey, Wu Jinhua, Surrey Lea, Álvarez-Quilón Alejandro, Vallée Frédéric, Nejad Parham, Schonhoft Joseph, Li Joanna, Veloso Artur, Young Jordan, Hyer Marc, Morris Stephen, Mossé Yael P, Marshall Gary, Haber Michelle, Zimmermann Michal

Protein arginine methyltransferase 5 (PRMT5) is an actionable therapeutic target in CDK4/6 inhibitor-resistant ER+/RB-deficient breast cancer

蛋白质精氨酸甲基转移酶5 (PRMT5) 是 CDK4/6 抑制剂耐药的 ER+/RB 缺陷型乳腺癌中一个可靶向的治疗靶点。

Lin, Chang-Ching; Chang, Tsung-Cheng; Wang, Yunguan; Guo, Lei; Gao, Yunpeng; Bikorimana, Emmanuel; Lemoff, Andrew; Fang, Yisheng V; Zhang, He; Zhang, Yanfeng; Ye, Dan; Soria-Bretones, Isabel; Servetto, Alberto; Lee, Kyung-Min; Luo, Xuemei; Otto, Joseph J; Akamatsu, Hiroaki; Napolitano, Fabiana; Mani, Ram; Cescon, David W; Xu, Lin; Xie, Yang; Mendell, Joshua T; Hanker, Ariella B; Arteaga, Carlos L

CFI-402257, a TTK inhibitor, effectively suppresses hepatocellular carcinoma

CFI-402257 是一种 TTK 抑制剂,可有效抑制肝细胞癌。

Chan, Cerise Yuen-Ki; Chiu, David Kung-Chun; Yuen, Vincent Wai-Hin; Law, Cheuk-Ting; Wong, Bowie Po-Yee; Thu, Kelsie Lynn; Cescon, David Ward; Soria-Bretones, Isabel; Cheu, Jacinth Wing-Sum; Lee, Derek; Tse, Aki Pui-Wah; Zhang, Misty Shuo; Tan, Kel Vin; Ng, Irene Oi-Lin; Khong, Pek-Lan; Yau, Thomas Chung-Cheung; Bray, Mark Robert; Mak, Tak Wah; Wong, Carmen Chak-Lui