日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Conformational Restriction of Designer Drugs Reveals Subtype-Selective and Biased CB(2) Agonists with Neuroprotective Effects.

构象限制设计药物揭示了具有神经保护作用的亚型选择性和偏向性 CB(2) 激动剂

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.5c00604
Gioé-Gallo Claudia, Ortigueira Sandra, Prieto-Díaz Rubén, Contino Marialessandra, Azuaje Jhonny, Perrone Maria Grazia, Riganti Chiara, Alberga Domenico, Mangiatordi Giuseppe Felice, Andújar-Arias Antonio, García-Rey Aitor, Graziano Giovanni, Stefanachi Angela, Val Cristina, Martínez Antón Leandro, Rebassa Joan Biel, Reza David, Selas Asier, Francavilla Fabio, Paleo M Rita, García-Mera Xerardo, Loza M Isabel, Navarro Gemma, Brea José, Sotelo Eddy
神经科学
药物研究
发表日期：2025
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Cannabinoid CB(1) Receptor Activation Mitigates N‑Methyl‑d‑aspartate Receptor-Mediated Neurotoxicity

大麻素CB(1)受体激活可减轻N-甲基-D-天冬氨酸受体介导的神经毒性

期刊:ACS Pharmacology and Translational Science
影响因子:3.7
doi:10.1021/acsptsci.5c00230
Navarro, Gemma; Raïch, Iu; Rebassa, Joan Biel; Lillo, Jaume; Pérez-Olives, Catalina; Capó, Toni; Cubeles, Erik; Saura, Carlos A; Cordomí, Arnau; Sotelo, Eddy; Reyes-Resina, Irene; Franco, Rafael
信号转导
毒理研究
发表日期：2025
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Multicomponent Reaction-Assisted Drug Discovery: A Time- and Cost-Effective Green Approach Speeding Up Identification and Optimization of Anticancer Drugs

多组分反应辅助药物发现：一种省时省钱的绿色方法，可加速抗癌药物的发现和优化

期刊:International Journal of Molecular Sciences
影响因子:4.9
doi:10.3390/ijms24076581
Graziano, Giovanni; Stefanachi, Angela; Contino, Marialessandra; Prieto-Díaz, Rubén; Ligresti, Alessia; Kumar, Poulami; Scilimati, Antonio; Sotelo, Eddy; Leonetti, Francesco
肿瘤
肿瘤免疫
发表日期：2023
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Deciphering conformational selectivity in the A2A adenosine G protein-coupled receptor by free energy simulations

利用自由能模拟解析A2A腺苷G蛋白偶联受体的构象选择性

期刊:PLoS Computational Biology
影响因子:3.6
doi:10.1371/journal.pcbi.1009152
Jespers, Willem; Heitman, Laura H; IJzerman, Adriaan P; Sotelo, Eddy; van Westen, Gerard J P; Åqvist, Johan; Gutiérrez-de-Terán, Hugo
信号转导
发表日期：2021
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X-Ray Crystallography and Free Energy Calculations Reveal the Binding Mechanism of A(2A) Adenosine Receptor Antagonists

X射线晶体学和自由能计算揭示了A(2A)腺苷受体拮抗剂的结合机制

期刊:Angewandte Chemie-International Edition
影响因子:16.9
doi:10.1002/anie.202003788
Jespers, Willem; Verdon, Grégory; Azuaje, Jhonny; Majellaro, Maria; Keränen, Henrik; García-Mera, Xerardo; Congreve, Miles; Deflorian, Francesca; de Graaf, Chris; Zhukov, Andrei; Doré, Andrew S; Mason, Jonathan S; Åqvist, Johan; Cooke, Robert M; Sotelo, Eddy; Gutiérrez-de-Terán, Hugo
信号转导
发表日期：2020
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The European Research Network on Signal Transduction (ERNEST): Toward a Multidimensional Holistic Understanding of G Protein-Coupled Receptor Signaling

欧洲信号转导研究网络（ERNEST）：迈向对G蛋白偶联受体信号传导的多维整体理解

期刊:ACS Pharmacology and Translational Science
影响因子:3.7
doi:10.1021/acsptsci.0c00024
Sommer, Martha E; Selent, Jana; Carlsson, Jens; De Graaf, Chris; Gloriam, David E; Keseru, Gyorgy M; Kosloff, Mickey; Mordalski, Stefan; Rizk, Aurelien; Rosenkilde, Mette M; Sotelo, Eddy; Tiemann, Johanna K S; Tobin, Andrew; Vardjan, Nina; Waldhoer, Maria; Kolb, Peter
信号转导
NEST
发表日期：2020
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Computer-aided design of multi-target ligands at A(1)R, A(2A)R and PDE10A, key proteins in neurodegenerative diseases

利用计算机辅助设计针对神经退行性疾病关键蛋白 A(1)R、A(2A)R 和 PDE10A 的多靶点配体

期刊:Journal of Cheminformatics
影响因子:5.7
doi:10.1186/s13321-017-0249-4
Kalash, Leen; Val, Cristina; Azuaje, Jhonny; Loza, María I; Svensson, Fredrik; Zoufir, Azedine; Mervin, Lewis; Ladds, Graham; Brea, José; Glen, Robert; Sotelo, Eddy; Bender, Andreas
神经科学
PDE10
发表日期：2017
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Structure-Based Design of Potent and Selective Ligands at the Four Adenosine Receptors

基于结构的四种腺苷受体高效选择性配体设计

期刊:Molecules
影响因子:4.6
doi:10.3390/molecules22111945
Jespers, Willem; Oliveira, Ana; Prieto-Díaz, Rubén; Majellaro, María; Åqvist, Johan; Sotelo, Eddy; Gutiérrez-de-Terán, Hugo
信号转导
发表日期：2017
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Synthesis and Characterization of a New Bivalent Ligand Combining Caffeine and Docosahexaenoic Acid.

合成与表征一种结合咖啡因和二十二碳六烯酸的新型二价配体

期刊:Molecules
影响因子:4.6
doi:10.3390/molecules22030366
Fernández-Dueñas Víctor, Azuaje Jhonny, Morató Xavier, Cordobilla Begoña, Domingo Joan Carles, Sotelo Eddy, Ciruela Francisco
发表日期：2017
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