Loss of μ opioid receptor signaling in nociceptors, but not microglia, abrogates morphine tolerance without disrupting analgesia.
伤害感受器(而非小胶质细胞)中α阿片受体信号的丧失会消除吗啡耐受性,而不会破坏镇痛作用
期刊:Nature Medicine
影响因子:50
doi:10.1038/nm.4262
Corder Gregory, Tawfik Vivianne L, Wang Dong, Sypek Elizabeth I, Low Sarah A, Dickinson Jasmine R, Sotoudeh Chaudy, Clark J David, Barres Ben A, Bohlen Christopher J, Scherrer Grégory